Regulation of CD4 T cell memory by OX40 (CD134).

abstract：:In many countries, foot and mouth disease (FMD) is controlled by vaccination and surveillance against non-capsid proteins (NCP); therefore vaccines are required not to induce antibodies against NCP. Vaccine purity is evaluated by repeated inoculation of naïve cattle, an expensive and time consuming protocol that raise...

journal_title：Vaccine

authors： Capozzo AV,Martínez MR,Schielen WJ

更新日期：2010-09-14 00:00:00

abstract：:Parainfluenza virus type 1 (PIV1) is a major cause of croup in infants and young children, and a vaccine is needed to prevent the serious disease caused by this virus. In the present study, a live attenuated PIV1 vaccine candidate was generated by modification of the extensively-studied PIV3 cold-passaged (cp) cp45 va...

journal_title：Vaccine

authors： Skiadopoulos MH,Tao T,Surman SR,Collins PL,Murphy BR

更新日期：1999-10-14 00:00:00

abstract：:Pneumococcal conjugate vaccines (PCV) may reduce nasopharyngeal carriage (NPC) of Streptococcus pneumoniae vaccine strains (VT), but serotype replacement with non-vaccine strains (NVT) has been reported. Bacterial NPC after PHiD-CV vaccination was assessed in the second year of life. Open descriptive study of NPC repo...

journal_title：Vaccine

authors： Prymula R,Hanovcova I,Splino M,Kriz P,Motlova J,Lebedova V,Lommel P,Kaliskova E,Pascal T,Borys D,Schuerman L

更新日期：2011-02-24 00:00:00

abstract：:Mycobacterium w (Mw), is a cultivable, non-pathogenic mycobacterium and has been tried extensively as an immunomodulator in leprosy. This has been found to be safe and has shown beneficial immunoprophylactic effect in population based, double blind placebo controlled trials in North India. These effects were also obse...

journal_title：Vaccine

authors： Katoch K,Singh P,Adhikari T,Benara SK,Singh HB,Chauhan DS,Sharma VD,Lavania M,Sachan AS,Katoch VM

更新日期：2008-02-26 00:00:00

abstract：:A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protect...

journal_title：Vaccine

authors： Tang LH,Lim JH,Kuah LF,Lau YF

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:In September 2011, the German Standing Committee on Vaccinations (STIKO) changed their recommendation regarding the mumps-measles-rubella-varicella vaccination (MMRV). We compared the immunization rates against MMRV in Germany before and after the STIKO intervention. METHODS:We recorded the immunization sta...

journal_title：Vaccine

authors： Sanftenberg L,Schrörs HJ,Schelling J

更新日期：2016-07-25 00:00:00

abstract：:The Salmonella rfc gene encodes the O-antigen polymerase. We constructed three strains in which we replaced the native rfc promoter with the arabinose-dependent araC P(BAD) promoter so that rfc expression was dependent on exogenously supplied arabinose provided during in vitro growth. The three mutant strains were des...

journal_title：Vaccine

authors： Kong Q,Liu Q,Jansen AM,Curtiss R 3rd

更新日期：2010-08-23 00:00:00

abstract：:Foot-and-mouth disease (FMD) is a highly contagious vesicular disease that affects domestic and wild cloven-hoofed animals worldwide. Recently, a series of outbreaks of type A FMDV occurred in Southeast Asian countries, China, the Russia Federation, Mongolia, Kazakhstan and South Korea. The FMD virus (A/GDMM/CHA/2013)...

journal_title：Vaccine

authors： Zheng H,Lian K,Yang F,Jin Y,Zhu Z,Guo J,Cao W,Liu H,He J,Zhang K,Li D,Liu X

更新日期：2015-10-26 00:00:00

abstract：:Since 1999, Italy has been challenged by several epidemics of Notifiable Avian Influenza (NAI) of the H5 and H7 subtypes, occurring in the densely populated poultry areas of northern part of the country. Vaccination with a conventional vaccine containing a seed strain with a different neuraminidase subtype to the fiel...

journal_title：Vaccine

authors： Capua I,Marangon S

更新日期：2007-06-28 00:00:00

abstract：:Pseudomonas aeruginosa antimicrobial resistance is a major therapeutic challenge. DNA vaccination is an attractive approach for antigen-specific immunotherapy against P. aeruginosa. We explored the feasibility of employing Herpes simplex virus type 1 tegument protein, VP22, as a molecular tool to enhance the immunogen...

journal_title：Vaccine

authors： Yu X,Wang Y,Xia Y,Zhang L,Yang Q,Lei J

更新日期：2016-08-17 00:00:00

abstract：:Influenza H3N2 viruses have recently drifted from A/Wisconsin/67/05-like to A/Brisbane/10/07-like viruses. The effect of key amino acid substitutions in the hemagglutinin (HA) protein on the replication, antigenicity and immunogenicity of cold-adapted, live attenuated vaccine strains was examined. A/Brisbane/10/07 egg...

journal_title：Vaccine

authors： Chen Z,Zhou H,Jin H

更新日期：2010-05-28 00:00:00

abstract：:Group W135 polysaccharide vaccines were licensed without efficacy trials using the serum bactericidal antibody (SBA) assay as a surrogate of protection. Standardization of group A and C SBA assays has been largely achieved. However, no such efforts have been focussed on W135. Although W135 strains have been recommende...

journal_title：Vaccine

authors： Balmer P,Borrow R

更新日期：2007-09-03 00:00:00

abstract：:Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase t...

journal_title：Vaccine

authors： Xu M,Xing X,Wu Z,Du Y,Hu T

更新日期：2015-10-26 00:00:00

abstract：:Mathematical models of HPV vaccine effectiveness and cost-effectiveness have produced conflicting results. The aim of this study was to use mathematical models to compare and isolate the impact of the assumptions most commonly made when modeling the effectiveness of HPV vaccines. Our results clearly show that differen...

journal_title：Vaccine

authors： Van de Velde N,Brisson M,Boily MC

更新日期：2010-07-26 00:00:00

abstract：:Immunogenicity of inactivated virus or subviral vaccines may be enhanced by complexing with an IgG antibody. Such antibody would increase the uptake, processing and presentation of the vaccine's antigens by antigen presenting cells (APC), via the adhesion of the antibody-vaccine complex to Fc-receptors on macrophages ...

journal_title：Vaccine

authors： Galili U,Repik PM,Anaraki F,Mozdzanowska K,Washko G,Gerhard W

更新日期：1996-03-01 00:00:00

abstract：:A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human vo...

journal_title：Vaccine

authors： Esparza J,Osmanov S,Pattou-Markovic C,Touré C,Chang ML,Nixon S

更新日期：2002-05-06 00:00:00

abstract：:In the present study the homologous and heterologous type and subtype specific cellular immune response induced by a wild type inactivated whole virus H5N1 Influenza (A/Vietnam/1203/2004) vaccine was evaluated. Two immunizations with the Vero cell derived H5N1 influenza vaccine on Day 0 and Day 21 induced significant ...

journal_title：Vaccine

authors： Crowe BA,Brühl P,Gerencer M,Schwendinger MG,Pilz A,Kistner O,Koelling-Schlebusch K,Aichinger G,Singer J,Zeitlinger M,Müller M,Ehrlich H,Barrett PN

更新日期：2010-12-16 00:00:00

abstract：:A live Salmonella Enteritidis vaccine (SE147N ΔphoP fliC), able to express both a homologous intestinal colonisation-inhibition effect and a systemic invasion-inhibition effect, was tested for its potential to generate a postulated additive protective effect in case of combined application with a competitive exclusion...

journal_title：Vaccine

authors： Methner U,Berndt A,Locke M

更新日期：2017-10-27 00:00:00

abstract：:The adenylate cyclase (CyaA) produced by Bordetella pertussis is able to deliver CD8+ and CD4+ T-cell epitopes genetically grafted within the catalytic domain of the molecule into antigen presenting cells in vivo. We develop now a new approach in which peptides containing CD8+ epitopes are chemically linked to CyaA. W...

journal_title：Vaccine

authors： Fayolle C,Bauche C,Ladant D,Leclerc C

更新日期：2004-12-16 00:00:00

abstract：:Immunization with Mycobacterium bovis Bacille Calmette-Guerin (BCG) did not induce adequate Th1 responses to the latency antigen, HspX of M. tuberculosis. To increase the immunogenicity and protective efficacy of BCG, a recombinant BCG strain over-expressing antigen HspX (rBCG::X) was constructed. The recombinant stra...

journal_title：Vaccine

authors： Shi C,Chen L,Chen Z,Zhang Y,Zhou Z,Lu J,Fu R,Wang C,Fang Z,Fan X

更新日期：2010-07-19 00:00:00

abstract：:The stockpiling of live vaccinia virus vaccines has enhanced biopreparedness against the intentional or accidental release of smallpox. Ongoing research on future generation smallpox vaccines is providing key insights into protective immune responses as well as important information about subunit-vaccine design strate...

journal_title：Vaccine

authors： Xiao Y,Zeng Y,Alexander E,Mehta S,Joshi SB,Buchman GW,Volkin DB,Middaugh CR,Isaacs SN

更新日期：2013-01-02 00:00:00

abstract：BACKGROUND:It has been assumed that measles infection may be associated with persistent immune suppression and long-term excess mortality. However, few community studies of mortality after measles infection have been carried out. We examined long-term mortality for measles cases, sub-clinical measles cases, and uninfec...

journal_title：Vaccine

authors： Aaby P,Simondon F,Samb B,Cisse B,Jensen H,Lisse IM,Soumaré M,Whittle H

更新日期：2002-11-22 00:00:00

abstract：:Intranasal (i.n.) vaccination with two suboptimal doses of 8 microg of deglycosylated chain A ricin (DGCA) stimulated low anti-ricin ELISA IgG and neutralizing antibody responses and the vaccine was only marginally protective against a lethal ricin toxin aerosol challenge. However, in the presence of 4, 2, or 1 microg...

journal_title：Vaccine

authors： Kende M,Del Giudice G,Rivera N,Hewetson J

更新日期：2006-03-15 00:00:00

abstract：:Gavi, the Vaccine Alliance, supports immunisation programmes in eligible countries to reach children with lifesaving vaccines. Dramatic improvement in the scale and performance of current cold chain systems is required to extend the reach of immunisation services - especially for children living in remote locations - ...

journal_title：Vaccine

authors： Azimi T,Franzel L,Probst N

更新日期：2017-04-19 00:00:00

abstract：:These studies were performed to determine the effects of GPI-0100, a semi synthetic Quillaja Saponin analog, formulated with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) on immunity to HSV. SKH-1 hairless mice, used as a model of herpes labialis, inoculated with HSV-1 results in facial lesions, virus replic...

journal_title：Vaccine

authors： Quenelle DC,Collins DJ,Marciani DJ,Kern ER

更新日期：2006-03-06 00:00:00

abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...

journal_title：Vaccine

authors： De Vleeschauwer AR,Zhou X,Lefebvre DJ,Garnier A,Watier F,Pignon C,Lacour SA,Zientara S,Bakkali-Kassimi L,De Clercq K,Klonjkowski B

更新日期：2018-04-12 00:00:00

abstract：:This study expands and updates through 1995 our earlier report on influenza vaccine use in 18 developed countries. Five of the six countries with high levels of vaccine use in 1992 (> or = 130 doses/1000 population) showed little change or slight declines over the subsequent 3 years. The exception was the United State...

journal_title：Vaccine

authors： Fedson DS,Hirota Y,Shin HK,Cambillard PE,Kiely J,Ambrosch F,Hannoun C,Leese J,Sprenger MJ,Hampson AW,Bro-Jørgensen K,Ahlbom AM,Nøkleby H,Valle M,Olafsson O,Salmerón F,Cloetta J,Rebelo de Andrade H,Snacken R,Donatell

更新日期：1997-10-01 00:00:00

abstract：INTRODUCTION:Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, there has been a tremendous progress in the reduction of cases of poliomyelitis. The world is on the verge of achieving global polio eradication and in May 2013, the 66th World Health Assembly endorsed the Polio Eradication and End...

journal_title：Vaccine

authors： Mwengee W,Okeibunor J,Poy A,Shaba K,Mbulu Kinuani L,Minkoulou E,Yahaya A,Gaturuku P,Landoh DE,Nsubuga P,Salla M,Mihigo R,Mkanda P

更新日期：2016-10-10 00:00:00

abstract：:We investigated whether pre-existing adenovirus-specific immunity influenced the development of immunity to a foreign antigen expressed by recombinant adenovirus. Active adenovirus-specific immunity was induced in cotton rats by i.n. administration of wild type human adenovirus type 5 (HAd5) two weeks before immunisat...

journal_title：Vaccine

authors： Papp Z,Babiuk LA,Baca-Estrada ME

更新日期：1999-02-26 00:00:00

abstract：:Sindbis replicon-based vaccine vectors are designed to combine the immunostimulatory properties of replicating viruses with the superior safety profile of non-replicating systems. In this study we performed a detailed assessment of Sindbis (SIN) replicon vectors expressing HIV-1 envelope protein (Env) for the inductio...

journal_title：Vaccine

authors： Center RJ,Miller A,Wheatley AK,Campbell SM,Siebentritt C,Purcell DF

更新日期：2013-04-26 00:00:00