Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.


:The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpesvirus recombinant expressing the fusion (F) gene of NDV (rHVT-ND) and/or at day-old with an apathogenic enterotropic live ND vaccine co-administrated or not with chitosan by oculo-nasal route. The induced vaccinal immune responses and conferred protection against a challenge with a circulating NDV velogenic viscerotropic strain were evaluated. The innovative rHVT-ND/live ND-chitosan vaccination regimen provided the best protection against mortality and morbidity as well as the strongest reduction of virus shedding that could be related to the higher measured cellular immune response and digestive antibody-mediated immunity.






Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B




Has Abstract


2010-01-08 00:00:00
















  • Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.

    abstract::Optimized DNA vectors were constructed comprising the proteome of SIV including the structural, enzymatic, regulatory, and accessory proteins. In addition to native antigens as produced by the virus, fusion proteins and modified antigens with altered secretion, cellular localization and stability characteristics were ...


    pub_type: 杂志文章


    authors: Kulkarni V,Jalah R,Ganneru B,Bergamaschi C,Alicea C,von Gegerfelt A,Patel V,Zhang GM,Chowdhury B,Broderick KE,Sardesai NY,Valentin A,Rosati M,Felber BK,Pavlakis GN

    更新日期:2011-09-09 00:00:00

  • Expansion of syndromic vaccine preventable disease surveillance to include bacterial meningitis and Japanese encephalitis: evaluation of adapting polio and measles laboratory networks in Bangladesh, China and India, 2007-2008.

    abstract:BACKGROUND:Surveillance for acute flaccid paralysis with laboratory confirmation has been a key strategy in the global polio eradication initiative, and the laboratory platform established for polio testing has been expanded in many countries to include surveillance for cases of febrile rash illness to identify measles...


    pub_type: 杂志文章


    authors: Cavallaro KF,Sandhu HS,Hyde TB,Johnson BW,Fischer M,Mayer LW,Clark TA,Pallansch MA,Yin Z,Zuo S,Hadler SC,Diorditsa S,Hasan AS,Bose AS,Dietz V,AMES Study Group.

    更新日期:2015-02-25 00:00:00

  • Protective efficacy of vaccination by recombinant vaccinia virus against Neospora caninum infection.

    abstract::The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The ...


    pub_type: 杂志文章


    authors: Nishikawa Y,Inoue N,Xuan X,Nagasawa H,Igarashi I,Fujisaki K,Otsuka H,Mikami T

    更新日期:2001-01-08 00:00:00

  • The effect of HLA on immunological response to hepatitis B vaccine in healthy people: a meta-analysis.

    abstract:BACKGROUND AND AIM:Evidence is accumulating that several markers in the human leukocyte antigen (HLA) region have been associated with decreased or increased antibody response to hepatitis B vaccine in different individuals. This meta-analysis is to assess the associations of HLA class II DRB1 and DQB1 alleles with imm...


    pub_type: 杂志文章,meta分析


    authors: Li ZK,Nie JJ,Li J,Zhuang H

    更新日期:2013-09-13 00:00:00

  • Evaluation of potentially achievable vaccination coverage with simultaneous administration of vaccines among children in the United States.

    abstract:BACKGROUND:Routine administration of all age-appropriate doses of vaccines during the same visit is recommended for children by the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP). METHODS:Evaluate the potentially achievable vaccination coverage for ≥4 doses of di...


    pub_type: 杂志文章


    authors: Zhao Z,Smith PJ,Hill HA

    更新日期:2016-06-08 00:00:00

  • Intranasal vaccination with ebola virus GP amino acids 258-601 protects mice against lethal challenge.

    abstract::Ebola virus (EBOV) disease (EVD) leads to lethal hemorrhagic fever with a case fatality rate as high as 90%, thus posing a serious global public health concern. However, while several vaccines based on the EBOV glycoprotein have been confirmed to be effective in animal experiments, no licensed vaccines or effective tr...


    pub_type: 杂志文章


    authors: Su QD,He SH,Yi Y,Qiu F,Lu XX,Jia ZY,Meng QL,Fan XT,Tian RG,Audet J,Qiu XG,Bi SL

    更新日期:2018-10-01 00:00:00

  • Safety and immunogenicity of a Vi-DT typhoid conjugate vaccine: Phase I trial in Healthy Filipino adults and children.

    abstract:BACKGROUND:Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2-14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overco...


    pub_type: 杂志文章,随机对照试验


    authors: Capeding MR,Teshome S,Saluja T,Syed KA,Kim DR,Park JY,Yang JS,Kim YH,Park J,Jo SK,Chon Y,Kothari S,Yang SY,Ham DS,Ryu JH,Hwang HS,Mun JH,Lynch JA,Kim JH,Kim H,Excler JL,Sahastrabuddhe S

    更新日期:2018-06-18 00:00:00

  • Immunization of rabbits with Glossina pallidipes tsetse fly midgut proteins: effects on the fly and trypanosome transmission.

    abstract::Proteins isolated from the midgut of Glossina pallidipes were used to immunize rabbits and their efficacy as vaccine candidate(s) against the fly, and their potential to block transmission of Trypanosoma brucei rhodesiense assessed. Two fractions, detergent (DET) and aqueous (AQ) fractions were separated using a non-i...


    pub_type: 杂志文章


    authors: Kinyua JK,Nguu EK,Mulaa F,Ndung'u JM

    更新日期:2005-05-31 00:00:00

  • Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine.

    abstract::Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase t...


    pub_type: 杂志文章


    authors: Xu M,Xing X,Wu Z,Du Y,Hu T

    更新日期:2015-10-26 00:00:00

  • BBG2Na an RSV subunit vaccine candidate intramuscularly injected to human confers protection against viral challenge after nasal immunization in mice.

    abstract::Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In t...


    pub_type: 杂志文章


    authors: Goetsch L,Plotnicky-Gilquin H,Aubry JP,De-Lys P,Haeuw JF,Bonnefoy JY,Nguyen NT,Corvaïa N,Velin D

    更新日期:2001-07-16 00:00:00

  • Does influenza vaccination improve pregnancy outcome? Methodological issues and research needs.

    abstract::Evidence that influenza vaccination during pregnancy is safe and effective at preventing influenza disease in women and their children through the first months of life is increasing. Several reports of reduced risk of adverse outcomes associated with influenza vaccination have generated interest in its potential for i...


    pub_type: 杂志文章,评审


    authors: Savitz DA,Fell DB,Ortiz JR,Bhat N

    更新日期:2015-11-25 00:00:00

  • Combined vaccination against yellow fever and typhoid fever: a comparative trial.

    abstract::In order to evaluate a combination of yellow fever and typhoid fever vaccine, we conducted a controlled trial comparing reactogenicity and immunogenicity of Vi polysaccharide (ViPS) vaccine and yellow fever 17D (YF) vaccine after single, simultaneous and combined administration. The combined YF/ViPS vaccine was prepar...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ambrosch F,Fritzell B,Gregor J,Jonas S,Kollaritsch H,Teulieres L,Wiedermann G

    更新日期:1994-05-01 00:00:00

  • Measles serological survey in the Italian population: interpretation of results using mixture model.

    abstract::In 2003-2004, a national measles seroprevalence study was conducted in Italy and data were analysed by using both commercial ELISA cut-off, and by applying a mixture model. Results of the two methods were compared and interpreted in the light of measles incidence, vaccination coverage and previous seroprevalence data....


    pub_type: 杂志文章


    authors: Rota MC,Massari M,Gabutti G,Guido M,De Donno A,Ciofi degli Atti ML

    更新日期:2008-08-12 00:00:00

  • Influence of elemental impurities in aluminum hydroxide adjuvant on the stability of inactivated Japanese Encephalitis vaccine, IXIARO®.

    abstract::Aluminum hydroxide is a critical raw material in the production of many vaccines. It is used as an adjuvant in the formulation of the final bulk vaccine, and for this it must meet the specifications of the European Pharmacopeia Monograph. We investigated whether vaccine stability was affected by the presence of trace ...


    pub_type: 杂志文章


    authors: Schlegl R,Weber M,Wruss J,Low D,Queen K,Stilwell S,Lindblad EB,Möhlen M

    更新日期:2015-11-04 00:00:00

  • Recombinant retrovirus-derived virus-like particle-based vaccines induce hepatitis C virus-specific cellular and neutralizing immune responses in mice.

    abstract::While the immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood, it is now admitted that an effective vaccine against HCV will need to induce both cellular and humoral immune responses and address viral heterogeneity to prevent immune escape. We developed a vaccine platform spec...


    pub_type: 杂志文章


    authors: Huret C,Desjardins D,Miyalou M,Levacher B,Amadoudji Zin M,Bonduelle O,Combadière B,Dalba C,Klatzmann D,Bellier B

    更新日期:2013-03-01 00:00:00

  • Decreased ratio of influenza-specific IgG versus IgM in response to influenza vaccination in antiretroviral-treated HIV-infected African Americans compared to Caucasians, and its direct correlation with the percentages of peripheral Tfh cells.

    abstract:BACKGROUND:Racial differences have been observed in the rate of bacterial infection and disease progression in HIV. Here, we evaluate racial differences in seasonal influenza vaccine responses. METHODS:16 healthy controls (9 Caucasians (CC) and 7 African Americans (AA)) and 26 antiretroviral therapy (ART)-treated avir...


    pub_type: 杂志文章


    authors: Ma P,Luo Z,Qian J,Yan Z,Zhang L,Martin L,Wang Z,Xia H,Yu F,Jiang W

    更新日期:2020-02-18 00:00:00

  • Factors underlying suboptimal childhood immunisation.

    abstract::This review considers possible reasons behind parents' missed vaccination opportunities in the context of the latest immunisation coverage rates for England. Suboptimal uptake is not exclusive to measles, mumps and rubella (MMR). A substantial proportion of children also miss diphtheria, tetanus and polio vaccination....


    pub_type: 杂志文章,评审


    authors: Tickner S,Leman PJ,Woodcock A

    更新日期:2006-11-30 00:00:00

  • Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescents across the US.

    abstract:BACKGROUND:While many clinicians encounter parents or adolescents who refuse HPV vaccine, little is known about the prevalence of hesitancy for HPV vaccine nationally or its association with vaccination. METHODS:In April 2019, we surveyed families with adolescents 11-17 years using a national online panel (Knowledge P...


    pub_type: 杂志文章


    authors: Szilagyi PG,Albertin CS,Gurfinkel D,Saville AW,Vangala S,Rice JD,Helmkamp L,Zimet GD,Valderrama R,Breck A,Rand CM,Humiston SG,Kempe A

    更新日期:2020-08-27 00:00:00

  • Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert.

    abstract::A recombinant fowlpox vaccine with an H5 hemagglutinin gene insert protected chickens against clinical signs and death following challenge by nine different highly pathogenic H5 avian influenza viruses. The challenge viruses had 87.3 to 100% deduced hemagglutinin amino acid sequence similarity with the recombinant vac...


    pub_type: 杂志文章


    authors: Swayne DE,Garcia M,Beck JR,Kinney N,Suarez DL

    更新日期:2000-01-06 00:00:00

  • Comparison of platform technologies for assaying antibody to Ebola virus.

    abstract:BACKGROUND:The recent Ebola outbreak in West Africa led to the use of a variety of different platform technologies for assaying antibodies because of the difficulties of handling the live virus. The same types of method could be applied rapidly to other infections when they emerge. There is a need to compare quantitati...


    pub_type: 杂志文章


    authors: Wilkinson DE,Page M,Mattiuzzo G,Hassall M,Dougall T,Rigsby P,Stone L,Minor P

    更新日期:2017-03-01 00:00:00

  • Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice.

    abstract::Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in d...


    pub_type: 杂志文章


    authors: Solans L,Uranga S,Aguilo N,Arnal C,Gomez AB,Monzon M,Badiola JJ,Gicquel B,Martin C

    更新日期:2014-09-08 00:00:00

  • Second-year surveillance of recipients of a respiratory syncytial virus (RSV) F protein subunit vaccine, PFP-1: evaluation of antibody persistence and possible disease enhancement.

    abstract::In a previous study, children 18 to 36 months of age and seropositive for respiratory syncytial virus (RSV) were vaccinated with an RSV subunit vaccine (PFP-1) consisting of the viral fusion protein. Vaccines developed substantial increases in anti-fusion and neutralizing antibody and exhibited protection against RSV ...


    pub_type: 临床试验,杂志文章


    authors: Tristram DA,Welliver RC,Hogerman DA,Hildreth SW,Paradiso P

    更新日期:1994-05-01 00:00:00

  • Protection of swine from foot-and-mouth disease with one dose of an all-D retro peptide.

    abstract::Nine pigs were given a single inoculum of 100 microg of the all-D retro peptide corresponding to the immunodominant GH loop encompassing residues 141-159 of capsid protein VP1 of foot-and-mouth disease virus serotype A, sub-type 12. The peptide was conjugated to activated keyhole limpet haemocyanin and oil-adjuvanted ...


    pub_type: 杂志文章


    authors: Nargi F,Kramer E,Mezencio J,Zamparo J,Whetstone C,Van Regenmortel MH,Briand JP,Muller S,Brown F

    更新日期:1999-07-16 00:00:00

  • Hepatitis C virus soluble E2 in combination with QuilA and CpG ODN induces neutralizing antibodies in mice.

    abstract::Several studies have emphasized the importance of an early, highly neutralizing antibody response in the clearance of Hepatitis C virus (HCV) infection. The envelope glycoprotein E2 is a major target for HCV neutralizing antibodies. Here, we compared antibody responses in mice immunized with native soluble E2 (sE2) fr...


    pub_type: 杂志文章


    authors: Naarding MA,Falkowska E,Xiao H,Dragic T

    更新日期:2011-04-05 00:00:00

  • Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth.

    abstract::An effective malaria vaccine remains a global health priority. Recombinant adenoviruses are a promising vaccine platform, and Plasmodium falciparum apical membrane antigen 1 (AMA1) and merozoite surface protein 1-42 (MSP1(42)) are leading blood stage vaccine candidates. We evaluated the importance of surface antigen l...


    pub_type: 杂志文章


    authors: Bruder JT,Stefaniak ME,Patterson NB,Chen P,Konovalova S,Limbach K,Campo JJ,Ettyreddy D,Li S,Dubovsky F,Richie TL,King CR,Long CA,Doolan DL

    更新日期:2010-04-19 00:00:00

  • Reducing the loss of vaccines from accidental freezing in the cold chain: the experience of continuous temperature monitoring in Tunisia.

    abstract::Accidental freezing of vaccines is a growing threat and a real risk for national immunization programs when the potency of many vaccines can be compromised if these are exposed to sub-zero temperatures in the cold chain. In Tunisia, this issue is compounded by using sub-standard domestic cold chain equipment instead o...


    pub_type: 杂志文章


    authors: Lloyd J,Lydon P,Ouhichi R,Zaffran M

    更新日期:2015-02-11 00:00:00

  • Genetic to genomic vaccination.

    abstract::Our development of genetic immunization (unfortunately named 'DNA'-immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. The is particularly a ...


    pub_type: 杂志文章


    authors: Johnston SA,Barry MA

    更新日期:1997-06-01 00:00:00

  • Heterologous HA DNA vaccine prime--inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses.

    abstract::The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...


    pub_type: 杂志文章


    authors: Wang S,Parker C,Taaffe J,Solórzano A,García-Sastre A,Lu S

    更新日期:2008-07-04 00:00:00

  • Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line.

    abstract::Cell culture-based manufacturing of influenza vaccines is ideally based on easily scalable platforms using suspension cells that grow in chemically defined media. Consequently, different adherent cell lines selected for high virus yields were adapted to grow in suspension culture. This includes the MDCK suspension cel...


    pub_type: 杂志文章


    authors: Peschel B,Frentzel S,Laske T,Genzel Y,Reichl U

    更新日期:2013-11-19 00:00:00

  • Influence of live respiratory syncytial virus priming on the immune response generated by a recombinant vaccine candidate, BBG2Na.

    abstract::Respiratory syncytial virus is one of the major respiratory pathogens for infants and immunocompromized children. With the exception of young children, all the population has encountered RSV and is seropositive. Recent reports have demonstrated however that the virus also affects the elderly and represents a major cau...


    pub_type: 杂志文章


    authors: Goestch L,Plotnicky-Gilquin H,Champion T,Beck A,Haeuw JF,Nguyen T,Bonnefoy JY,Corvaïa N

    更新日期:2000-06-01 00:00:00