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Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis.

Abstract：

:Pharmacological manipulation of the balance between pro- and anti-inflammatory mediators emerges as a key aspect of a successful treatment of sepsis. A murine model of septic shock was developed and chosen conjugates (1a, 1b, 8a, 8c) and analogs (T2) of muramyl dipeptide and tuftsin were tested in this model as prospective anti-bacterial drugs or adjuvants. The phagocytic activity of monocytes/macrophages was determined (flow cytometry, bacterial clearance from vital organs). To evaluate cytokines levels (TNFalpha, IFNgamma, IL6, IL10) we used real-time PCR. The most promising immunomodulatory properties were displayed by the analogue T2 and two conjugates: 8a, 8c.

journal_name

Vaccine

journal_title

Vaccine

authors

Wardowska A,Dzierzbicka K,Szaryńska M,Dabrowska-Szponar M,Wiśniewska K,Myśliwski A,Trzonkowski P

doi

10.1016/j.vaccine.2008.11.017

subject

Has Abstract

pub_date

2009-01-14 00:00:00

pages

369-74

issue

3

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)01528-4

journal_volume

27

pub_type

杂志文章

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