Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China.

abstract：:Six adjuvant formulations were compared for their ability to potentiate the primary and memory antibody responses in mice to three companion animal vaccine immunogens--feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and a recombinantly-derived heartworm antigen. The combination of a novel bacterial ...

journal_title：Vaccine

authors： Usinger WR

更新日期：1997-12-01 00:00:00

abstract：:Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a potent threat to human health. Although immunization with recombinant poxviruses expressing protective antigens as vaccines has been widely used for against many infectious diseases, development of recombinant swinepox virus (...

journal_title：Vaccine

authors： Xu J,Huang D,Liu S,Lin H,Zhu H,Liu B,Lu C

更新日期：2012-04-26 00:00:00

abstract：:The presence of resident Langerhans cells (LCs) in the epidermis makes the skin an attractive target for DNA vaccination. However, reliable animal models for cutaneous vaccination studies are limited. We demonstrate an ex vivo human skin model for cutaneous DNA vaccination which can potentially bridge the gap between ...

journal_title：Vaccine

authors： Ng KW,Pearton M,Coulman S,Anstey A,Gateley C,Morrissey A,Allender C,Birchall J

更新日期：2009-10-09 00:00:00

abstract：BACKGROUND:In England, coverage for childhood vaccines have decreased since 2012/13 in the context of an increasingly visible anti-vaccination discourse. We determined whether anti-vaccination sentiment is the likely cause of this decline in coverage. METHODS:Descriptive study triangulating a range of data sources (va...

journal_title：Vaccine

authors： Edelstein M,Müller M,Ladhani S,Yarwood J,Salathé M,Ramsay M

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...

journal_title：Vaccine

authors： Thoon KC,Tee NW,Chew L,Chong CY

更新日期：2014-10-07 00:00:00

abstract：:Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly directed against an amino acid sequence in the third hypervariable domain. We ...

journal_title：Vaccine

authors： Achour A,Picard O,Mbika JP,Willer A,Snart R,Bizzini B,Carelli C,Burny A,Zagury D

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program is the immunization safety monitoring component of FDA's Mini-Sentinel project, a program to actively monitor the safety of medical products using electronic health information. FDA sought to assess the surveillance capabilities of this ...

journal_title：Vaccine

authors： Baker MA,Nguyen M,Cole DV,Lee GM,Lieu TA

更新日期：2013-12-30 00:00:00

abstract：:Viral hemorrhagic septicemia (VHS) in olive flounder (Paralichthys olivaceus) remains an unsolved health problem in Korean aquaculture. Vaccination plays a significant role in modern aquaculture, and the duration of protection provided is of vital importance. Here, we have demonstrated the efficacy, duration of protec...

journal_title：Vaccine

authors： Vinay TN,Kim YJ,Jung MH,Kim WS,Kim DH,Jung SJ

更新日期：2013-09-23 00:00:00

abstract：:We recently developed a novel immunomodulating gene fusion protein, CTA1-DD, that combines the ADP-ribosylating ability of cholera toxin (CT) with a dimer of an Ig-binding fragment, D, of Staphylococcus aureus protein A. The CTA1-DD adjuvant was found to be non-toxic and greatly augmented T cell dependent and independ...

journal_title：Vaccine

authors： Lycke N,Schön K

更新日期：2001-03-21 00:00:00

abstract：:The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has residual toxicity that can be detected in cell-based assays and in-viv...

journal_title：Vaccine

authors： Wang B,Wang S,Rustandi RR,Wang F,Mensch CD,Hong L,Kristopeit A,Secore S,Dornadula G,Kanavage A,Heinrichs JH,Mach H,Blue JT,Thiriot DS

更新日期：2015-01-01 00:00:00

abstract：:Vaccination remains the most cost-effective biomedical approach for controlling influenza disease. In times of pandemics, however, these vaccines cannot be produced in sufficient quantities for worldwide use by the current manufacturing capacities and practices. What is needed is the development of adjuvanted vaccines...

journal_title：Vaccine

authors： Jain S,George PJ,Deng W,Koussa J,Parkhouse K,Hensley SE,Jiang J,Lu J,Liu Z,Wei J,Zhan B,Bottazzi ME,Shen H,Lustigman S

更新日期：2018-06-14 00:00:00

abstract：:A major challenge for poultry vaccination is the design of vaccines that protect against multiple pathogens via a single protective dose delivered through mass vaccination methods. In this investigation, we examined herpesvirus of turkeys (HVT) as a vaccine vector for delivery of haemagglutinin (HA) antigen of highly ...

journal_title：Vaccine

authors： Li Y,Reddy K,Reid SM,Cox WJ,Brown IH,Britton P,Nair V,Iqbal M

更新日期：2011-10-26 00:00:00

abstract：:Dengue disease is a global challenge for healthcare systems particularly during outbreaks, and millions of dollars are spent every year for vector control. An efficient and safe vaccine that is cost-effective could resolve the burden that dengue virus imposes on affected countries. We describe here the immunogenicity ...

journal_title：Vaccine

authors： Zuest R,Valdes I,Skibinski D,Lin Y,Toh YX,Chan K,Hermida L,Connolly J,Guillen G,Fink K

更新日期：2015-03-17 00:00:00

abstract：OBJECTIVES:To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN:Cross-sectional online survey. SETTING:Data ...

journal_title：Vaccine

authors： Smith LE,Webster RK,Weinman J,Amlôt R,Yiend J,Rubin GJ

更新日期：2017-04-04 00:00:00

abstract：:Influenza is a significant cause of morbidity and mortality for pregnant women and infants worldwide. Influenza vaccination during pregnancy has been shown to be safe and highly effective and should be recommended for all pregnant women before the influenza season. Despite existing recommendations, the vaccine is unde...

journal_title：Vaccine

authors： Blanchard-Rohner G,Siegrist CA

更新日期：2011-10-06 00:00:00

abstract：:Genetic diversity and hypermutation contribute to difficulties in developing a vaccine against viruses like HIV and influenza. There are currently no known immune correlates of protection against HIV. This has made the development of a vaccine against HIV that would provide sterilizing immunity in the near future an i...

journal_title：Vaccine

authors： Kotwal GJ

更新日期：2008-06-06 00:00:00

abstract：:The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent va...

journal_title：Vaccine

authors： Penfound TA,Chiang EY,Ahmed EA,Dale JB

更新日期：2010-07-12 00:00:00

abstract：:The stockpiling of live vaccinia virus vaccines has enhanced biopreparedness against the intentional or accidental release of smallpox. Ongoing research on future generation smallpox vaccines is providing key insights into protective immune responses as well as important information about subunit-vaccine design strate...

journal_title：Vaccine

authors： Xiao Y,Zeng Y,Alexander E,Mehta S,Joshi SB,Buchman GW,Volkin DB,Middaugh CR,Isaacs SN

更新日期：2013-01-02 00:00:00

abstract：:In this review we aim to provide the reader with an understanding of the capsular-based complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine development. We then discuss the need for a new vaccine strategy based on proteic antigen candidates discovered in silico. Describing specifical...

journal_title：Vaccine

authors： Barocchi MA,Censini S,Rappuoli R

更新日期：2007-04-20 00:00:00

abstract：:Codon-pair bias de-optimization (CPBD) of viruses involves re-writing viral genes using statistically underrepresented codon pairs, without any changes to the amino acid sequence or codon usage. Previously, this technology has been used to attenuate the influenza A/Puerto Rico/8/34 (H1N1) virus. The de-optimized virus...

journal_title：Vaccine

authors： Broadbent AJ,Santos CP,Anafu A,Wimmer E,Mueller S,Subbarao K

更新日期：2016-01-20 00:00:00

abstract：:The minor glycoproteins (GPs) of PRRSV, GP2, GP3, and GP4, form a heterotrimer that is required for viral infectivity, presumably due to its interaction with the key cellular receptor CD163. These 3GPs are encoded by open reading frames (ORFs) 2a, 3 and 4 (herein referred to as ORFs 2-4), respectively. The goal of thi...

journal_title：Vaccine

authors： Kimpston-Burkgren K,Correas I,Osorio FA,Steffen D,Pattnaik AK,Fang Y,Vu HLX

更新日期：2017-08-03 00:00:00

abstract：:The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...

journal_title：Vaccine

authors： Wang S,Parker C,Taaffe J,Solórzano A,García-Sastre A,Lu S

更新日期：2008-07-04 00:00:00

abstract：:This cross-sectional study aimed to assess pertussis seroprevalence among healthy healthcare workers (HCW) of the Children's Hospital of Tunis, Tunisia. During the study period, 236 blood samples were obtained to determine HCW exposure to pertussis. Concentrations of immunoglobulin G (IgG) to pertussis toxin (PT) were...

journal_title：Vaccine

authors： Ben Fraj I,Smaoui H,Zghal M,Sassi O,Guiso N,Kechrid A

更新日期：2019-01-03 00:00:00

abstract：:Research into active immunisation against gonadotrophin releasing hormone (GnRH-I) has gained widespread acceptance as a means of controlling reproduction and behaviour of farm, companion and wild animals. Many studies describe the use of multiple copies of the self-peptide in linear alignment and conjugation with a l...

journal_title：Vaccine

authors： Khan MA,Ogita K,Ferro VA,Kumasawa K,Tsutsui T,Kimura T

更新日期：2008-03-04 00:00:00

abstract：BACKGROUND:Non-specific effects (NSEs) of vaccines have increasingly gained attention in recent years. Recent studies suggest that live vaccines, such as measles vaccine (MV), have beneficial effects on health, while inactivated vaccines, such as the diphtheria-tetanus-pertussis (DTP) vaccine, may have harmful effects....

journal_title：Vaccine

authors： Schoeps A,Nebié E,Fisker AB,Sié A,Zakane A,Müller O,Aaby P,Becher H

更新日期：2018-04-05 00:00:00

abstract：:Selection bias is of critical concern in the study of influenza vaccine effectiveness when using an observational study design. This bias is attributable to the inherently different characteristics between vaccinees and non-vaccinees. The differences, which are related both to vaccination and signs of clinical disease...

journal_title：Vaccine

authors： Fukushima W,Hayashi Y,Mizuno Y,Suzuki K,Kase T,Ohfuji S,Fujieda M,Maeda A,Hirota Y

更新日期：2008-11-25 00:00:00

abstract：:Organised and quality assured cytology-based screening programmes have substantially reduced cervical cancer incidence in many developed countries. However, there are considerable barriers to setting up cytology-based screening programs, particularly in developing countries. This has stimulated the search for novel an...

journal_title：Vaccine

authors： Denny L,Quinn M,Sankaranarayanan R

更新日期：2006-08-31 00:00:00

abstract：BACKGROUND:Immunization programs currently measure coverage by assessing the proportion of children 12-24 months who have been immunized but this does not address the important question of when the scheduled vaccines were administered. Data capturing the timing of vaccination in first 6 months, when severe disease is m...

journal_title：Vaccine

authors： Hughes MM,Katz J,Englund JA,Khatry SK,Shrestha L,LeClerq SC,Steinhoff M,Tielsch JM

更新日期：2016-02-10 00:00:00

abstract：BACKGROUND:High incidence and serotype diversity of invasive pneumococcal disease (IPD) in Indigenous children in remote Australia led to rapid introduction of 7-valent conjugate pneumococcal vaccine (7vPCV) at 2, 4 and 6 months in 2001, followed by 23-valent polysaccharide pneumococcal vaccine (23vPPV) in the second y...

journal_title：Vaccine

authors： Jayasinghe S,Chiu C,Menzies R,Lehmann D,Cook H,Giele C,Krause V,McIntyre P

更新日期：2015-11-27 00:00:00

abstract：:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic varia...

journal_title：Vaccine

authors： DeDiego ML,Chiem K,Topham DJ

更新日期：2018-10-15 00:00:00