Abstract：
:The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.
journal_name
Vaccinejournal_title
Vaccineauthors
Penfound TA,Chiang EY,Ahmed EA,Dale JBdoi
10.1016/j.vaccine.2010.05.018subject
Has Abstractpub_date
2010-07-12 00:00:00pages
5017-22issue
31eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)00694-8journal_volume
28pub_type
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