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Directed selection of amino acid changes in the influenza hemagglutinin and neuraminidase affecting protein antigenicity.

Abstract：

:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic variability of these proteins by growing the viruses under immune pressure provided by human sera. In this work, we show that after growing different influenza virus strains under immune pressure, the selection of amino acid changes in the NA protein is much more limited than the selection in the HA protein, suggesting that the NA protein could remain more conserved under immune pressure. Interestingly, all the mutations in the HA and NA proteins affected protein antigenicity, and many of the selected amino acid changes were located at the same positions found in viruses circulating. These studies could help to inform HA and NA protein residues targeted by antibody responses after virus infection in humans and are very relevant to update the strains used for influenza virus vaccination each year and to improve the currently available vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

DeDiego ML,Chiem K,Topham DJ

doi

10.1016/j.vaccine.2018.09.005

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

6383-6392

issue

43

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(18)31240-4

journal_volume

36

pub_type

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