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GM-CSF-surface-modified B16.F10 melanoma cell vaccine.

Abstract：

:Through the specific and tight interaction between streptavidin and biotin, a novel platform was developed to allow for rapid (less than 2h), efficient and durable display of streptavidin-tagged bioactive GM-CSF on the surface of biotinylated B16.F10 tumor cells. This technology involved biotinylation of the cell membrane with a biotin derivative and surface modification of the biotinylated cells with the bi-functional fusion protein, streptavidin-tagged GM-CSF. Furthermore, the resultant GM-CSF-modified B16.F10 whole tumor cell vaccine could induce strong and long-lasting systemic protection against the wild-type tumor challenge. Therefore, the platform may represent a fast, efficient and safe approach for the whole tumor cell vaccination.

journal_name

Vaccine

journal_title

Vaccine

authors

Gao J,Huang S,Li M,Luo R,Wang X,Takashima A

doi

10.1016/j.vaccine.2006.04.031

subject

Has Abstract

pub_date

2006-06-19 00:00:00

pages

5265-8

issue

25

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00468-3

journal_volume

24

pub_type

杂志文章

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