Abstract：
:Millions of people worldwide are currently infected with human papillomaviruses (HPVs). A therapeutic HPV vaccine would have widespread applicability because HPV-associated lesions are difficult to treat and may progress to carcinoma. We developed three attenuated VSV recombinants expressing the cottontail rabbit papillomavirus (CRPV) early protein E6 for use as vaccines. In cultured cells, two vectors expressed different levels of the E6 protein, and one expressed a ubiquitin-E6 fusion protein. All three were tested for therapeutic efficacy in the cottontail rabbit papillomavirus (CRPV)-rabbit model. Mock vaccination had no effect on papilloma growth. In contrast, inoculation with any of the VSV-E6 vaccines reduced the rate of papilloma growth to as little as 24% the rate in the controls. In five experiments, these effects were achieved after a single immunization. Furthermore, complete papilloma regression occurred in some rabbits observed for 4 months. A VSV-based papillomavirus E6 vaccine could have significant advantages over other therapeutic HPV vaccine candidates described to date.
journal_name
Vaccinejournal_title
Vaccineauthors
Brandsma JL,Shlyankevich M,Buonocore L,Roberts A,Becker SM,Rose JKdoi
10.1016/j.vaccine.2006.08.012subject
Has Abstractpub_date
2007-01-08 00:00:00pages
751-62issue
4eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)00954-6journal_volume
25pub_type
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