当前位置： SCI文献检索 > VACCINE期刊下所有文献 > N-fragment of edema factor as a candidate antigen for immunization against anthrax.

N-fragment of edema factor as a candidate antigen for immunization against anthrax.

Abstract：

:The nontoxic N-terminal fragment of Bacillus anthracis edema factor (EF) was evaluated as a candidate antigen in an anthrax vaccine using a replication-incompetent adenoviral vector. An E1/E3 deleted adenovirus (Ad/EFn) encoding the N-terminal region 1-254 amino acids of the edema factor (EFn) was constructed using the native DNA sequence of EFn. Intramuscular immunization three times with 10(8) plaque forming units (pfu)/dose of Ad/EFn in A/J mice resulted in 37% and 57% protection against a subcutaneous challenge with B. anthracis Sterne strain spores at a dosage of 200 x LD50 and 100 x LD50, respectively. EF-specific serum IgG responses (including total IgG, IgG1, and IgG2a isotype titers) were robust in the Ad/EFn immunized animals. Interestingly, anti-EF antibodies cross-reacted with anthrax lethal factor (LF), and had a neutralizing capability against both anthrax lethal toxin (Letx) and edema toxin (Edtx), as demonstrated by in vitro toxin neutralization assays using J774A.1 mouse macrophage and Chinese hamster ovary cell (CHO), respectively. Our data suggest that EF plays a role in eliciting protective immunity against anthrax, and that it should be included in a new generation multi-component subunit vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Zeng M,Xu Q,Hesek ED,Pichichero ME

doi

10.1016/j.vaccine.2005.08.056

subject

Has Abstract

pub_date

2006-01-30 00:00:00

pages

662-70

issue

5

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00871-6

journal_volume

24

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Noncytopathic bovine viral diarrhea virus can persist in testicular tissue after vaccination of peri-pubertal bulls but prevents subsequent infection.

    abstract：:The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronega...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.037

    authors： Givens MD,Riddell KP,Walz PH,Rhoades J,Harland R,Zhang Y,Galik PK,Brodersen BW,Cochran AM,Brock KV,Carson RL,Stringfellow DA

    更新日期：2007-01-15 00:00:00

  • Experimental infection by Chlamydia pneumoniae in the hamster.

    abstract：:We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes a systemic infection allowing the isolation of viable chlamydiae from several organs for several days post-infection (p.i.). In particular, spleen infection occurred up to Day 7 p.i. in 100% of anima...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.09.035

    authors： Sambri V,Donati M,Storni E,Di Leo K,Agnusdei M,Petracca R,Finco O,Grandi G,Ratti G,Cevenini R

    更新日期：2004-03-12 00:00:00

  • A qualitative study on knowledge, perceptions, and attitudes of mothers and health care providers toward pneumococcal conjugate vaccine in Bandung, West Java, Indonesia.

    abstract：UNLABELLED:Due to the high burden of pneumonia in Indonesia, the inclusion of pneumococcal conjugate vaccine (PCV) into Indonesia's National Immunization Program (NIP) is recommended by World Health Organization. Prior to the introduction of new vaccines, it is imperative to assess the perceptions of the public and med...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.01.007

    authors： Harjaningrum AT,Kartasasmita C,Orne-Gliemann J,Jutand MA,Goujon N,Koeck JL

    更新日期：2013-03-01 00:00:00

  • A population-based study on tetanus antitoxin levels in The Netherlands.

    abstract：:We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00186-3

    authors： de Melker HE,van den Hof S,Berbers GA,Nagelkerke NJ,Rümke HC,Conyn-van Spaendonck MA

    更新日期：1999-08-20 00:00:00

  • Evaluation of 238 antigens of Leptospira borgpetersenii serovar Hardjo for protection against kidney colonisation.

    abstract：:Leptospirosis is a zoonotic disease affecting animals and humans worldwide. Leptospiral infection in cattle can cause reproductive failure and reduced weight gain, and importantly, infection represents a significant disease risk for farmers. Current bacterin vaccines offer protection that is short-lived and restricted...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.11.028

    authors： Murray GL,Lo M,Bulach DM,Srikram A,Seemann T,Quinsey NS,Sermswan RW,Allen A,Adler B

    更新日期：2013-01-07 00:00:00

  • Safety, immunogenicity, and kinetics of the immune response to a single dose of virosome-formulated hepatitis A vaccine in Thais.

    abstract：:The safety and immunogenicity of a single dose of virosome-formulated hepatitis A vaccine was evaluated in healthy seronegative Thai volunteers. Immunization elicited primarily mild transient reactions which did not interfere with normal activities. All subjects possessed > 20 mIU of anti-hepatitis A virus antibody pe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)00007-n

    authors： Poovorawan Y,Theamboonlers A,Chumdermpadetsuk S,Glück R,Cryz SJ Jr

    更新日期：1995-07-01 00:00:00

  • Murine cytomegalovirus inactivated by sodium periodate is innocuous and immunogenic in mice and protects them against death and infection.

    abstract：:Sodium periodate (10 mM, 4 degrees C) inactivated murine cytomegalovirus (MCMV) very rapidly (loss of 2 to 3 log of viral infectivity per minute). Periodate-treated MCMV (PI-MCMV) was shown to be innocuous in mice, as determined by the inability of the virus to replicate. PI-MCMV induced a strong humoral immune respon...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00116-8

    authors： Geoffroy F,Moachon N,Rodwell J,Quash GA

    更新日期：1996-12-01 00:00:00

  • Childhood vaccinations: Hidden impact of COVID-19 on children in Singapore.

    abstract：:Although the direct health impact of Coronavirus disease (COVID-19) pandemic on child health is low, there are indirect impacts across many aspects. We compare childhood vaccine uptake in three types of healthcare facilities in Singapore - public primary care clinics, a hospital paediatric unit, and private paediatric...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.12.054

    authors： Zhong Y,Clapham HE,Aishworiya R,Chua YX,Mathews J,Ong M,Wang J,Murugasu B,Chiang WC,Lee BW,Chin HL

    更新日期：2021-01-29 00:00:00

  • A novel mouse model for immunogenic evaluation of human HBV vaccines.

    abstract：:To prepare a human HBV vaccine, investigators need an animal model that can help them screen and prioritize vaccine candidates. In this study, HBV/HLA-A2.1 double transgenic mice (dTg), confirmed by analysis of genomic integration and by observation of long-term expression of HBV and HLA genes, were generated for the ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.088

    authors： Guo Y,Ren D,He X,Wang F,Jiang L,Song S,He Y,Sun S

    更新日期：2009-09-18 00:00:00

  • Safety and immunogenicity of heterologous prime-boost immunization with viral-vectored malaria vaccines adjuvanted with Matrix-M™.

    abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.09.028

    authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

    更新日期：2017-10-27 00:00:00

  • Seroprevalence of diphtheria immunity among injured adults in Austria.

    abstract：:Over a period of 1 year a seroepidemiological study was conducted at the outpatient clinic of a trauma department. Immunity to diphtheria was determined in serum samples from 558 injured patients (205 women and 353 men, age from 18 to 70). Diphtheria-antitoxin concentrations were measured with an enzyme immunoassay an...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00341-8

    authors： Marlovits S,Stocker R,Efstratiou A,Broughton K,Kaider A,Vécsei V,Wiedermann G,Kollaritsch H

    更新日期：2000-12-08 00:00:00

  • In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG.

    abstract：:The varied rates of protection induced by Mycobacterium bovis BCG vaccine against tuberculosis has been attributed to many factors such as genetic variability among BCG strains, rapid clearance of BCG in some populations, and different levels of previous exposure of vaccinated populations to environmental mycobacteria...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.12.044

    authors： Venkataswamy MM,Goldberg MF,Baena A,Chan J,Jacobs WR Jr,Porcelli SA

    更新日期：2012-02-01 00:00:00

  • Recombinant retrovirus-derived virus-like particle-based vaccines induce hepatitis C virus-specific cellular and neutralizing immune responses in mice.

    abstract：:While the immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood, it is now admitted that an effective vaccine against HCV will need to induce both cellular and humoral immune responses and address viral heterogeneity to prevent immune escape. We developed a vaccine platform spec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.025

    authors： Huret C,Desjardins D,Miyalou M,Levacher B,Amadoudji Zin M,Bonduelle O,Combadière B,Dalba C,Klatzmann D,Bellier B

    更新日期：2013-03-01 00:00:00

  • Sero-epidemiology of measles and mumps in Korea: impact of the catch-up campaign on measles immunity.

    abstract：:A catch-up campaign targeting children aged 8-16 years using measles-rubella (MR) vaccine was conducted during 2001 in Korea. To evaluate the impact of the campaign and assess mumps immunity, human IgG antibodies were detected using ELISA for measles (5826 samples) and mumps (5890 samples) in a national sample of oppo...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2004.07.030

    authors： Kim SS,Han HW,Go U,Chung HW

    更新日期：2004-12-02 00:00:00

  • Comparative analysis of immunization schedules using a novel adenovirus-based immunotherapeutic targeting hepatitis B in naïve and tolerant mouse models.

    abstract：:Development of active targeted immunotherapeutics is a rapid developing field in the arena of chronic infectious diseases. The question of repeated, closely spaced administration of immunotherapeutics to achieve a rapid impact on the replicating agent is an important one. We analyzed here, using a prototype adenovirus...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.03.089

    authors： Boukhebza H,Dubois C,Koerper V,Evlachev A,Schlesinger Y,Menguy T,Silvestre N,Riedl P,Inchauspé G,Martin P

    更新日期：2014-05-30 00:00:00

  • Absence of YF-neutralizing antibodies in vulnerable populations of Brazil: A warning for epidemiological surveillance and the potential risks for future outbreaks.

    abstract：:Yellow Fever (YF) is an acute febrile illness caused by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted to humans and non-human primates. In Brazil, YF is a public health threat and may cause recurrent epidemics, even with the availability of a vaccine. We evaluated the sero-status for YFV in 581 ind...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.07.077

    authors： Stoffella-Dutra AG,Silva de Oliveira J,Barbosa Costa G,Geessien Kroon E,Santos Abrahão J,Desiree LaBeaud A,Paiva Drumond B,Bretas de Oliveira D,de Souza Trindade G

    更新日期：2020-09-29 00:00:00

  • STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice.

    abstract：BACKGROUND:One of the most concerning public health issues, related to vaccination and disease prevention, is the inability to induce durable immune responses following a single-dose immunization. In this regard, the nature of the inflammatory environment induced by vaccine adjuvants can negatively impact the resulting...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.04.004

    authors： Darling RJ,Senapati S,Kelly SM,Kohut ML,Narasimhan B,Wannemuehler MJ

    更新日期：2019-05-06 00:00:00

  • Phase 1 testing of detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant for the prevention and treatment of sepsis.

    abstract：BACKGROUND:Gram-negative bacteria (GNB) are a leading cause of nosocomial infection and sepsis. Increasing multi-antibiotic resistance has left clinicians with fewer therapeutic options. Antibodies to GNB lipopolysaccharide (LPS, or endotoxin) have reduced morbidity and mortality as a result of infection and are not su...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.10.072

    authors： Cross AS,Greenberg N,Billington M,Zhang L,DeFilippi C,May RC,Bajwa KK

    更新日期：2015-11-27 00:00:00

  • Booster response to recombinant yeast-derived hepatitis B vaccine in vaccinees whose anti-HBs responses were initially elicited by a plasma-derived vaccine.

    abstract：:One hundred and eight primary school students who had been vaccinated with three doses of a plasma-derived hepatitis B vaccine were randomly divided into two groups, to receive a booster dose of either the same vaccine or of a recombinant yeast-derived vaccine. The pre-booster anti-hepatitis B surface antigen (HBs) ge...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(91)90294-g

    authors： Chan CY,Lee SD,Tsai YT,Lo KJ

    更新日期：1991-10-01 00:00:00

  • A randomized, double-blind, controlled clinical trial to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, in healthy volunteers.

    abstract：:A randomized, double-blind, controlled clinical trial was conducted to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, and to determine its minimum effective dose. The overall rates of cutaneous "take" reaction and humoral and cellular immunogenicity in CJ-50300 v...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.06.063

    authors： Jang HC,Kim CJ,Kim KH,Lee KH,Byun YH,Seong BL,Saletti G,Czerkinsky C,Park WB,Park SW,Kim HB,Kim NJ,Oh MD

    更新日期：2010-08-16 00:00:00

  • The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007.

    abstract：:Active surveillance was conducted by the 12 centers of the Canadian Immunization Monitoring Program, Active from 2000-2007 in children 16 years of age and younger to determine the influence of 7-valent pneumococcal conjugate immunization programs on the prevalence, serotype and antibiotic resistance patterns of invasi...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2009.12.026

    authors： Bettinger JA,Scheifele DW,Kellner JD,Halperin SA,Vaudry W,Law B,Tyrrell G,Canadian Immunization Monitoring Program, Active (IMPACT).

    更新日期：2010-02-25 00:00:00

  • A bivalent conjugate vaccine in the treatment of biochemically relapsed prostate cancer: a study of glycosylated MUC-2-KLH and Globo H-KLH conjugate vaccines given with the new semi-synthetic saponin immunological adjuvant GPI-0100 OR QS-21.

    abstract：:GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated prostate cancer patients who had no evidence of disease except for ri...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.01.072

    authors： Slovin SF,Ragupathi G,Fernandez C,Jefferson MP,Diani M,Wilton AS,Powell S,Spassova M,Reis C,Clausen H,Danishefsky S,Livingston P,Scher HI

    更新日期：2005-05-02 00:00:00

  • Evaluation of adverse effects of vaccines: the case-control approach.

    abstract：:When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00147-0

    authors： Smeeth L,Rodrigues LC,Hall AJ,Fombonne E,Smith PG

    更新日期：2002-06-07 00:00:00

  • Current overview of the pathogenesis and prophylaxis of measles with focus on practical implications.

    abstract：:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(01)00384-x

    authors： Hilleman MR

    更新日期：2001-12-12 00:00:00

  • Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE).

    abstract：:Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligman, Gould, Lancet 2004;363:2073-5], it has little foundation [e.g., Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond J, Lang J, et al. Vaccine 2005;23:2956-8]. To invest...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.016

    authors： Pugachev KV,Schwaiger J,Brown N,Zhang ZX,Catalan J,Mitchell FS,Ocran SW,Rumyantsev AA,Khromykh AA,Monath TP,Guirakhoo F

    更新日期：2007-09-17 00:00:00

  • Persistence of long-term immunity to hepatitis B among adolescents immunized at birth.

    abstract：:The long-term duration of recombinant hepatitis B vaccine-induced immunity among persons vaccinated starting at birth is still not well understood. Waning of vaccine-induced immunity could leave young adults at risk of hepatitis B virus infection due to behavioral or occupational exposures. We followed a cohort of chi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.12.106

    authors： Chaves SS,Fischer G,Groeger J,Patel PR,Thompson ND,Teshale EH,Stevenson K,Yano VM,Armstrong GL,Samandari T,Kamili S,Drobeniuc J,Hu DJ

    更新日期：2012-02-21 00:00:00

  • Estimation of the potential overall impact of human papillomavirus vaccination on cervical cancer cases and deaths.

    abstract：BACKGROUND:Human papillomavirus (HPV) vaccination offers potential for primary prevention of HPV-related pre-cancers and cancers as demonstrated in clinical trials. Mathematical models have estimated the potential real-life impact of vaccination on the burden of cervical cancer (CC). However, these are restricted to ev...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.11.049

    authors： Van Kriekinge G,Castellsagué X,Cibula D,Demarteau N

    更新日期：2014-02-03 00:00:00

  • Use of protamine sulphate for elimination of substrate DNA in poliovaccines produced on continuous cell lines.

    abstract：:Cell substrate DNA was shown to be an abundant contaminant in the clarified preparations of the Sabin type 1, 2 and 3 poliovaccines produced on a continuous cell line (4647). The size of the DNA, as evaluated for the Sabin type 1 poliovaccine, was highly heterogeneous, ranging from 100 to 20,000 base pairs. In view of...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90156-z

    authors： Amosenko FA,Svitkin YV,Popova VD,Terletskaya EN,Timofeev AV,Elbert LB,Lashkevich VA,Drozdov SG

    更新日期：1991-03-01 00:00:00

  • Directed selection of amino acid changes in the influenza hemagglutinin and neuraminidase affecting protein antigenicity.

    abstract：:Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins are subject to antigenic drift, decreasing vaccine efficacy, and few to no studies have analyzed antigenic varia...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.09.005

    authors： DeDiego ML,Chiem K,Topham DJ

    更新日期：2018-10-15 00:00:00

  • Nature, evolution, and appraisal of adverse events and antibody response associated with the fifth consecutive dose of a five-component acellular pertussis-based combination vaccine.

    abstract：:We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 ...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0264-410x(03)00173-7

    authors： Halperin SA,Scheifele D,Mills E,Guasparini R,Humphreys G,Barreto L,Smith B

    更新日期：2003-06-02 00:00:00