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Sero-epidemiology of measles and mumps in Korea: impact of the catch-up campaign on measles immunity.

Abstract：

:A catch-up campaign targeting children aged 8-16 years using measles-rubella (MR) vaccine was conducted during 2001 in Korea. To evaluate the impact of the campaign and assess mumps immunity, human IgG antibodies were detected using ELISA for measles (5826 samples) and mumps (5890 samples) in a national sample of opportunistically collected sera from a population aged 0-34 years. The measles immunity increased by 5-10% following the catch-up campaign in the targeted age group. Infants lost maternal antibodies rapidly and about 90% of infants were susceptible to measles and mumps at 6-8 months of life. The sero-prevalence of mumps antibody increased slowly with age and stabilized at a lower level when compared with that of measles. Despite an immediate reduction in susceptibility among the targeted age group of the catch-up campaign, continuous efforts to increase immunization coverage are needed to interrupt indigenous measles transmission. Furthermore, our results suggest continuous mumps outbreaks could occur because of the accumulation of susceptible individuals.

journal_name

Vaccine

journal_title

Vaccine

authors

Kim SS,Han HW,Go U,Chung HW

doi

10.1016/j.vaccine.2004.07.030

subject

Has Abstract

pub_date

2004-12-02 00:00:00

pages

290-7

issue

3

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00585-7

journal_volume

23

pub_type

杂志文章,多中心研究

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