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Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam.

Abstract：

:We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

journal_name

Vaccine

journal_title

Vaccine

authors

Thiem VD,Deen JL,von Seidlein L,Canh DG,Anh DD,Park JK,Ali M,Danovaro-Holliday MC,Son ND,Hoa NT,Holmgren J,Clemens JD

doi

10.1016/j.vaccine.2006.03.008

subject

Has Abstract

pub_date

2006-05-15 00:00:00

pages

4297-303

issue

20

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00272-6

journal_volume

24

pub_type

杂志文章

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