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Evaluation of adverse effects of vaccines: the case-control approach.

Abstract：

:When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpretation of case-control studies to evaluate vaccine adverse effects. Potential biases (and how to minimise such biases) in the selection of cases and assessment of vaccine exposure and the potential for confounding are discussed. Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered.

journal_name

Vaccine

journal_title

Vaccine

authors

Smeeth L,Rodrigues LC,Hall AJ,Fombonne E,Smith PG

doi

10.1016/s0264-410x(02)00147-0

subject

Has Abstract

pub_date

2002-06-07 00:00:00

pages

2611-7

issue

19-20

eissn

0264-410X

issn

1873-2518

pii

S0264410X02001470

journal_volume

20

pub_type

杂志文章

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