Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses.

abstract：:Recombinant Adenovirus serotype 5 (Ad5) vectors have been used as vaccine platforms in numerous animal and human clinical studies. The immune response induced by Ad5 vaccines can be mitigated due to pre-existing Ad5 immunity. We previously reported the use of a novel Ad5 platform to induce cellular immune responses (C...

journal_title：Vaccine

authors： Gabitzsch ES,Xu Y,Yoshida LH,Balint J,Amalfitano A,Jones FR

更新日期：2009-10-30 00:00:00

abstract：:To circumvent limitations of poor antigen presentation and immunogenicity of DNA vaccines that target induction of CD8(+) T cell immunity, we have generated single chain MHC I trimers (MHC I SCTs) composed of a single polypeptide chain with a linear composition of antigenic peptide, β2-microglobulin, and heavy chain o...

journal_title：Vaccine

authors： Kim S,Zuiani A,Carrero JA,Hansen TH

更新日期：2012-03-09 00:00:00

abstract：:Malaria represents a major global health problem but despite extensive efforts, no effective vaccine is available. Various vaccine candidates have been developed that provide protection in animal models, such as a gene gun-delivered DNA vaccine encoding the circumsporozoite protein (CSP) of Plasmodium berghei. A commo...

journal_title：Vaccine

authors： Bergmann-Leitner ES,Leitner WW,Duncan EH,Savranskaya T,Angov E

更新日期：2009-09-18 00:00:00

abstract：:Monoclonal antibodies (MoAbs) reactive with the authentic Orientia tsutsugamushi 56-kDa protein were generated. MoAb FS10 and FS15 showed in vitro, as well as, in vivo neutralizing activity upon O. tsutsugamushi infection. Deletion mutants of the gene for 56-kDa protein of O. tsutsugamushi Boryong were expressed to ma...

journal_title：Vaccine

authors： Seong SY,Kim MK,Lee SM,Odgerel Z,Choi MS,Han TH,Kim IS,Kang JS,Lim BU

更新日期：2000-08-15 00:00:00

abstract：:Currently, commercial porcine rotavirus vaccines remain varied limitations. The objective of this study is to develop an alternative porcine rotavirus subunit vaccine candidate by parenteral administration, which enables to elicit robust immune responses against most prevalence porcine rotavirus strains. The bacterial...

journal_title：Vaccine

authors： Wen X,Wei X,Ran X,Ni H,Cao S,Zhang Y

更新日期：2015-08-26 00:00:00

abstract：BACKGROUND:Despite being committed to the immunization agenda set by the WHO, Italy is currently experiencing decreasing vaccination rates and increasing incidence of vaccine-preventable diseases. Our aim is to analyze Italian online debates on pediatric immunizations through a content analytic approach in order to qua...

journal_title：Vaccine

authors： Fadda M,Allam A,Schulz PJ

更新日期：2015-12-16 00:00:00

abstract：:An immuno-informatics study was conducted to determine possible pre-existing T cellular immunity to the recently emerged swine-origin triple reassortant H3N2 variant (S-OtrH3N2v-2011) which acquired the matrix gene of influenza A (H1N1)pdm09. Given the genetic origin of S-OtrH3N2v-2011, our study focused on the hemagg...

journal_title：Vaccine

authors： Duvvuri VR,Marchand-Austin A,Eshaghi A,Patel SN,Low DE,Gubbay JB

更新日期：2012-09-14 00:00:00

abstract：:The HIV epidemic in the south Indian state of Karnataka disproportionately burdens key populations of men who have sex with men and female sex workers. Despite having successfully reduced HIV incidence among certain key populations through the use of targeted intervention, India's HIV epidemic remains one of its great...

journal_title：Vaccine

authors： McClarty LM,Lorway RR,Ramanaik S,Wylie J,Becker ML

更新日期：2015-01-29 00:00:00

abstract：:Polymeric nanoparticles (NPs) of poly (lactic-co-glycolic) acid (PLGA) possess adjuvant properties. To date, there are few studies exploring their application as antigen carriers for vaccination of fish. This study presents a preclinical assessment of the early innate and adaptive immune responses in Atlantic salmon f...

journal_title：Vaccine

authors： Fredriksen BN,Sævareid K,McAuley L,Lane ME,Bøgwald J,Dalmo RA

更新日期：2011-10-26 00:00:00

abstract：AIMS:The study was designed to evaluate a novel cationic lipid DNA adjuvant (N3) and its function for HIV-1gp160/rev DNA plasmid delivered intranasally. The primary N3/HIV-DNA plasmid immunizations were boosted intranasally with a gp41 peptide in a anionic L3 adjuvant. This novel prime-boost strategy of mucosal immuniz...

journal_title：Vaccine

authors： Hinkula J,Devito C,Zuber B,Benthin R,Ferreira D,Wahren B,Schröder U

更新日期：2006-05-22 00:00:00

abstract：BACKGROUND:Poliomyelitis is endemic in Northern Nigeria where there is continuous transmission of wild poliovirus 1 and 3 (WPV1 and 3) and circulating vaccine derived poliovirus 2 (cVDPV2) resulting in a high number of cases of children with acute flaccid paralysis. The seroprevalence of antibodies to polio serotypes w...

journal_title：Vaccine

authors： Giwa FJ,Olayinka AT,Ogunshola FT

更新日期：2012-11-06 00:00:00

abstract：:Barriers to human papillomavirus (HPV) vaccine acceptability in Israel include Israel's relatively low incidence of cervical cancer; the religiously-based 80% circumcision rate in Israel, which is regarded as contributing to the lower incidence of HPV infection in the country; the fact that HPV vaccine provides immuni...

journal_title：Vaccine

authors： Fisher WA,Laniado H,Shoval H,Hakim M,Bornstein J

更新日期：2013-11-22 00:00:00

abstract：:Seven volunteers involved in flavivirus studies have been immunized with commercial Japanese encephalitis and yellow fever vaccines JE-VAX and YF-VAX. Strong homologous and cross-reactive with West Nile virus (WNV) antibody responses with titers 1:1600 to 1:51200 were found in all donors. All donors developed high lev...

journal_title：Vaccine

authors： Yamshchikov G,Borisevich V,Kwok CW,Nistler R,Kohlmeier J,Seregin A,Chaporgina E,Benedict S,Yamshchikov V

更新日期：2005-09-15 00:00:00

abstract：:Targeted delivery of vaccine candidates to the gastrointestinal (GI) tract holds potential for mucosal immunization, particularly against mucosal pathogens like the human immunodeficiency virus (HIV). Among the different strategies for achieving targeted release in the GI tract, namely the small intestine, pH sensitiv...

journal_title：Vaccine

authors： Mercier GT,Nehete PN,Passeri MF,Nehete BN,Weaver EA,Templeton NS,Schluns K,Buchl SS,Sastry KJ,Barry MA

更新日期：2007-12-17 00:00:00

abstract：:Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and vaccination is the primary tool for the disease control. Previously, we developed a more cost-effective PCV2 virus-like particle (VLP) vaccine by using ELPylation technology. In the present study, we compared the ELPylated VLP (ELP-VLP) P...

journal_title：Vaccine

authors： Li Y,Lin Y,Xin G,Zhou X,Lu H,Zhang X,Xia X,Sun H

更新日期：2020-05-13 00:00:00

abstract：INTRODUCTION:In September 2015, Nigeria was removed from the list of polio-endemic countries after more than 12months had passed since the detection of last wild poliovirus case in the country on 24 July 2014. We are presenting here a report of two polio seroprevalence surveys conducted in September 2013 and October 20...

journal_title：Vaccine

authors： Iliyasu Z,Verma H,Craig KT,Nwaze E,Ahmad-Shehu A,Jibir BW,Gwarzo GD,Gajida AU,Weldon WC,Steven Oberste M,Takane M,Mkanda P,Muhammad AJG,Sutter RW

更新日期：2016-09-30 00:00:00

abstract：:Twenty-nine classical swine fever virus (CSFv) strains were grown in the PK15 or SK6 cell lines. Antigenic differentiation studies were performed using monoclonal antibodies (McAbs), produced at Lelystad (CDI-DLO), The Netherlands. The monoclonals which were classified numerically as monoclonals 2-13. Epitope map patt...

journal_title：Vaccine

authors： Mendoza S,Correa-Giron P,Aguilera E,Colmenares G,Torres O,Cruz T,Romero A,Hernandez-Baumgarten E,Ciprián A

更新日期：2007-10-10 00:00:00

abstract：:The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...

journal_title：Vaccine

authors： Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

更新日期：2007-04-12 00:00:00

abstract：:The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...

journal_title：Vaccine

authors： Van Hoecke C,Comberbach M,De Grave D,Desmons P,Fu D,Hauser P,Lebacq E,Lobet Y,Voet P

更新日期：1996-12-01 00:00:00

abstract：:Current vaccine candidates against Rift Valley fever virus (RVFV) incorporate the viral structural glycoproteins as antigens, since triggering antibody responses against them usually correlates with protection. Here, we have focused solely on the nucleoprotein of RVFV as a potential target for vaccine development. Pre...

journal_title：Vaccine

authors： Boshra H,Lorenzo G,Rodriguez F,Brun A

更新日期：2011-06-15 00:00:00

abstract：:The highly pathogenic avian H5N1 influenza virus has the potential to incite a global pandemic. Therefore, there is an urgent need to develop effective vaccines against these viruses. Because it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to develop vaccines that will co...

journal_title：Vaccine

authors： Ichinohe T,Ainai A,Tashiro M,Sata T,Hasegawa H

更新日期：2009-10-23 00:00:00

abstract：:Dengue is a major infectious disease that affects people living in tropical and subtropical regions around the world. The causative agents are dengue virus serotype 1, 2, 3, and 4 (DENV1, 2, 3, and 4). Developing a vaccine for dengue is a high priority for public health, but traditional methods have faced numerous obs...

journal_title：Vaccine

authors： Pang X,Guo Y,Zhou Y,Fu W,Gu X

更新日期：2014-06-24 00:00:00

abstract：:The highly pathogenic avian influenza (HPAI) H5N1 viruses and their spillover into the human population pose substantial economic and public health threats. Although antiviral drugs have some effect in treating influenza infection, vaccination is still the most effective intervention to prevent possible pandemic outbr...

journal_title：Vaccine

authors： Lu Y,Landreth S,Liu G,Brownlie R,Gaba A,Littel-van den Hurk SVD,Gerdts V,Zhou Y

更新日期：2020-02-28 00:00:00

abstract：:Previous noninvasive vaccine submission approaches including respiratory tract-based methods are limited to specific pathogens. Recent developments on ultrasound biology suggest that ultrasound-mediated molecule submission (sonoporation) could be an effective noninvasive approach for gene therapy as well as drug submi...

journal_title：Vaccine

authors： Yuan TF

更新日期：2008-08-05 00:00:00

abstract：:In the face of an almost unprecedented threat of a global pandemic of influenza it is imperative that stockpiling of appropriate drugs and devices begin now. One vital device is an appropriate syringe for delivering vaccine. With the potential for millions to be infected and the vaccine supply severely stretched it is...

journal_title：Vaccine

authors： Strauss K,van Zundert A,Frid A,Costigliola V

更新日期：2006-05-29 00:00:00

abstract：BACKGROUND:The Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA) assessed vaccine-type community-acquired pneumonia (VT-CAP) and vaccine-type invasive pneumococcal disease (VT-IPD) prevention with 13-valent pneumococcal conjugate vaccine (PCV13) in adults aged ⩾65years. We report vaccine efficacy (VE) ...

journal_title：Vaccine

authors： Webber C,Patton M,Patterson S,Schmoele-Thoma B,Huijts SM,Bonten MJ,CAPiTA Study Group.

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease (CD) have a higher risk of infectious diseases including pneumococcal infections, and the risk increases with immunotherapy. The primary endpoint of this study was to investigate the specific antibody response to two pneumococcal vaccines in CD patients with and without immunosu...

journal_title：Vaccine

authors： Kantsø B,Halkjær SI,Thomsen OØ,Belard E,Gottschalck IB,Jørgensen CS,Krogfelt KA,Slotved HC,Ingels H,Petersen AM

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...

journal_title：Vaccine

authors： Thoon KC,Tee NW,Chew L,Chong CY

更新日期：2014-10-07 00:00:00

abstract：:Nucleic acid vaccination has many potential advantages over traditional methods, but suffers from the fact that DNA vaccines tend to be relatively poorly immunogenic. Attempts to enhance DNA vaccine immunogenicity have included the addition of cytokine-encoding plasmids into the formulation, as well as the use of hete...

journal_title：Vaccine

authors： Nimal S,McCormick AL,Thomas MS,Heath AW

更新日期：2005-06-10 00:00:00

abstract：:Infectious bronchitis virus (IBV) is an endemic disease of chickens and a major contributor to economic losses for the poultry industry despite vaccination. Recent observations indicated that chicks may have an immature immune system immediately after hatching when vaccinated for IBV. Therefore we hypothesized that ea...

journal_title：Vaccine

authors： van Ginkel FW,Padgett J,Martinez-Romero G,Miller MS,Joiner KS,Gulley SL

更新日期：2015-05-28 00:00:00