Noninvasive vaccination: from the perspective of sonoporation.

abstract：:Triton X-100 (TX-100) is the most common surfactant used to split viruses during the production of influenza split-virus vaccines. It is a mild surfactant not known to denature the viral proteins; this property makes TX-100 useful for maintaining antigen conformational structure, and, as an added benefit, for partiall...

journal_title：Vaccine

authors： Sahin Z,Neeleman R,Haines J,Kayser V

更新日期：2019-02-14 00:00:00

abstract：:Applicability of the endotoxin test to diphtheria-tetanus-acellular pertussis combined (DTaP) vaccines was examined. We found some DTaP vaccines that strongly interfered with Limulus amoebocyte lysate (LAL) activity of endotoxin without affecting lethal activity of endotoxin in D-galactosamine-treated mice. LAL activi...

journal_title：Vaccine

authors： Ochiai M,Kataoka M,Toyoizumi H,Kamachi K,Yamamoto A,Horiuchi Y

更新日期：2003-05-16 00:00:00

abstract：BACKGROUND:Although global progress in measles control has been realized, achieving elimination has proven difficult in many regions of the world. China has adopted a goal of measles elimination but recent outbreaks predominantly affecting children <8 months who are ineligible for vaccination and incompletely protected...

journal_title：Vaccine

authors： Janusz CB,Wagner AL,Masters NB,Ding Y,Zhang Y,Hutton DW,Boulton ML

更新日期：2020-06-15 00:00:00

abstract：:Theileria parva kills over one million cattle annually in sub-Saharan Africa. Parasite genetic complexity, cellular response immunodominance, and bovine MHC diversity have precluded traditional vaccine development. One potential solution is gene gun (GG) immunization, which enables simultaneous administration of one o...

journal_title：Vaccine

authors： Fry LM,Bastos RG,Stone BC,Williams LB,Knowles DP,Murphy SC

更新日期：2019-03-14 00:00:00

abstract：:Attenuated strains of Salmonella have been used as vaccines to deliver heterologous antigens mainly to generate a humoral immune response. However, little is known about their ability to induce a cell-mediated immune response to the T-cell epitopes of another infectious agent or how optimally to deliver these epitopes...

journal_title：Vaccine

authors： Verma NK,Ziegler HK,Stocker BA,Schoolnik GK

更新日期：1995-02-01 00:00:00

abstract：:We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

journal_title：Vaccine

authors： Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

更新日期：2000-06-01 00:00:00

abstract：:The objective of this study was to evaluate different preparations of avian metapneumovirus (aMPV) subtype C as vaccine challenge in turkeys. Two aMPV isolates and their respective nasal turbinate homogenates after propagation in turkeys were used in the study. Significantly higher clinical sign scores were recorded i...

journal_title：Vaccine

authors： Velayudhan BT,Noll SL,Thachil AJ,Shaw DP,Goyal SM,Halvorson DA,Nagaraja KV

更新日期：2007-02-26 00:00:00

abstract：:The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...

journal_title：Vaccine

authors： Forrest BD,LaBrooy JT

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Ebola viral disease (EVD) epidemic need to be contained through means which include vaccination of susceptible population. Vaccination has eradicated major killer diseases. OBJECTIVE:The study determined the health workers willingness to participate in EVD vaccine clinical trials and receive EVD vaccine. M...

journal_title：Vaccine

authors： Olowookere SA,Abioye-Kuteyi EA,Adekanle O

更新日期：2016-11-11 00:00:00

abstract：:The low-molecular-mass secretory proteins of Mycobacterium tuberculosis have been shown to be major T-cell antigens during infection with the pathogenic bacterium. In this study, we determined murine T-cell epitopes on three low-molecular-mass proteins, CFP11 (Rv2433c), CFP17 (Rv1827), and TB18.5 (Rv0164) using DNA im...

journal_title：Vaccine

authors： Eweda G,Suzuki D,Nagata T,Tsujimura K,Koide Y

更新日期：2010-06-23 00:00:00

abstract：:The target animals and vaccination regimes for vaccines against the bovine rhinotracheitis (IBR) and the bovine viral diarrhoea virus (BVDV) are very similar. Therefore, we have compared different schedules for the combined use of a live IBR marker vaccine and an inactivated BVD vaccine. The neutralizing antibody resp...

journal_title：Vaccine

authors： Alvarez M,Bielsa JM,Santos L,Makoschey B

更新日期：2007-09-04 00:00:00

abstract：:Dengue is a significant threat to public health worldwide. Currently, there are no licensed vaccines available for dengue. Takeda Vaccines Inc. is developing a live, attenuated tetravalent dengue vaccine candidate (TDV) that consists of an attenuated DENV-2 strain (TDV-2) and three chimeric viruses containing the prM ...

journal_title：Vaccine

authors： Osorio JE,Partidos CD,Wallace D,Stinchcomb DT

更新日期：2015-12-10 00:00:00

abstract：BACKGROUND:The World Health Organization recommends the development of affordable next-generation inactivated poliovirus vaccines (IPV) using attenuated poliovirus Sabin strains. Previously, we introduced a novel PER.C6® cell culture platform, which allows for high yield production of an affordable trivalent Sabin IPV ...

journal_title：Vaccine

authors： Bockstal V,Tiemessen MM,Achterberg R,Van Wordragen C,Knaapen AM,Serroyen J,Marissen WE,Schuitemaker H,Zahn R

更新日期：2018-11-12 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in children. The present study compares the level of attenuation, genetic stability and efficacy of three conditional-lethal temperature-sensitive (ts) mutants of the RSV A2 wild-type virus, designated ts-1, ts-1-NG1, and t...

journal_title：Vaccine

authors： Crowe JE Jr,Collins PL,London WT,Chanock RM,Murphy BR

更新日期：1993-11-01 00:00:00

abstract：:This study compared responses of bison calves to 10(10)CFU of Brucella abortus strain RB51 (SRB51) delivered by parenteral or ballistic methods. Two types of biobullet payloads were evaluated; compacted SRB51 pellets or SRB51 encapsulated in photopolymerized poly(ethylene glycol) hydrogels. Bison were vaccinated with ...

journal_title：Vaccine

authors： Olsen SC,Christie RJ,Grainger DW,Stoffregen WS

更新日期：2006-02-27 00:00:00

abstract：:Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this study, we explored the role that two deamidation-prone Asn residues located...

journal_title：Vaccine

authors： Verma A,Burns DL

更新日期：2018-10-15 00:00:00

abstract：:The feasibility of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine was assessed and a comparison made of immunogenicity and reactogenicity to DTPa and HBV vaccines mixed in one syringe and to concomitant but separate injections as a primary vaccination course in three groups of infants...

journal_title：Vaccine

authors： Usonis V,Bakasenas V,Willems P,Clemens R

更新日期：1997-10-01 00:00:00

abstract：:Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...

journal_title：Vaccine

authors： Baldridge JR,Ward JR

更新日期：1997-03-01 00:00:00

abstract：:The aim of this work was to evaluate the microencapsulation by spray-drying of inactivated Vibrio cholerae, using methacrylic copolymers Eudragit® L30D-55 and FS30D. The microparticles obtained presented a particle size around 3.0 μm. The preparation temperature affected the morphology and the antigenicity of micropar...

journal_title：Vaccine

authors： Año G,Esquisabel A,Pastor M,Talavera A,Cedré B,Fernández S,Sifontes S,Aranguren Y,Falero G,García L,Solís RL,Pedraz JL

更新日期：2011-08-05 00:00:00

abstract：BACKGROUND:Alternative methods for influenza vaccine production are needed to ensure adequate supplies. METHODS:Healthy adults 50-64 years were assigned randomly to receive one intramuscular injection of trivalent recombinant hemagglutinin (rHA) or U.S. licensed trivalent inactivated vaccine (TIV) containing H1, H3 an...

journal_title：Vaccine

authors： Baxter R,Patriarca PA,Ensor K,Izikson R,Goldenthal KL,Cox MM

更新日期：2011-03-09 00:00:00

abstract：:Technology transfer is a promising approach to increase vaccine production at an affordable price in developing countries. In the case of influenza, it is imperative that developing countries acquire the technology to produce pandemic vaccines through the transfer of know-how, as this will be the only way for the majo...

journal_title：Vaccine

authors： Miyaki C,Meros M,Precioso AR,Raw I

更新日期：2011-07-01 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute encephalitis with high mortality in humans. To understand the virus-host interactions that influence JEV virulence, we determined the lethality of a neurovirulent (RP-9) and an attenuated (RP-2ms) variant of JEV in several immunodeficie...

journal_title：Vaccine

authors： Liang JJ,Liao CL,Liao JT,Lee YL,Lin YL

更新日期：2009-05-11 00:00:00

abstract：:The human adenovirus type 19a/64 (hAd19a) is a rare serotype in the human population that transduces human dendritic cells (DCs) and human muscle cells more efficiently than the well-characterized human adenovirus type 5 (hAd5). To further characterize the potential of this vector as a vaccine we designed replication ...

journal_title：Vaccine

authors： Ragonnaud E,Schroedel S,Mariya S,Iskandriati D,Pamungkas J,Fougeroux C,Daradoumis J,Thomsen AR,Neukirch L,Ruzsics Z,Salomon M,Thirion C,Holst PJ

更新日期：2018-10-01 00:00:00

abstract：:We have demonstrated that vaccination of turkeys with an unformulated DNA vaccine induces significant protection against Chlamydophila (Cp.) psittaci infections. Nevertheless, the immunogenicity of the DNA vaccine can still be improved by increasing translation and transfection efficiency. Therefore, the ompA codon wa...

journal_title：Vaccine

authors： Verminnen K,Beeckman DS,Sanders NN,De Smedt S,Vanrompay DC

更新日期：2010-04-19 00:00:00

abstract：AIM:To establish whether universal vaccination of infants with the pneumococcal conjugate vaccine is likely to be cost-effective from the perspective of the health care provider (NHS). METHOD:Two hypothetical cohorts--one vaccinated and one unvaccinated--were followed over their lifetime, and the expected net costs an...

journal_title：Vaccine

authors： Melegaro A,Edmunds WJ

更新日期：2004-10-22 00:00:00

abstract：:The immunogenicity of 23-valent pneumococcal polysaccharide vaccine was assessed in 57 HIV-1 infected former intravenous drug users and in 20 HIV-1 negative controls. The effect of vaccination on HIV-1 infection was studied in a subgroup of 38 patients, 60% of whom under highly active antiretroviral therapy (HAART). A...

journal_title：Vaccine

authors： Amendola A,Tanzi E,Zappa A,Colzani D,Boschini A,Musher DM,Zanetti AR

更新日期：2002-11-01 00:00:00

abstract：:Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive...

journal_title：Vaccine

authors： Crum-Cianflone NF,Roediger M,Huppler Hullsiek K,Ganesan A,Landrum M,Weintrob A,Agan B,Medina S,Rahkola J,Hale B,Janoff EN,Infectious Disease Clinical Research Program HIV Working Group.

更新日期：2010-11-10 00:00:00

abstract：:The ability of Escherichia coli heat-labile enterotoxin (LT) to influence the induction and maintenance of tolerance was examined in animals primed orally with a soluble protein antigen, ovalbumin (OVA), or in animals primed orally with two unrelated protein antigens administered simultaneously, OVA and bovine serum a...

journal_title：Vaccine

authors： Clements JD,Hartzog NM,Lyon FL

更新日期：1988-06-01 00:00:00

abstract：:In 2013, avian H7N9 influenza viruses were detected infecting people in China resulting in high mortality. Influenza H7 vaccines that provide cross-protection against these new viruses are needed until specific H7N9 vaccines are ready to market. In this study, an available H7N3 cold-adapted, temperature sensitive, liv...

journal_title：Vaccine

authors： Carter DM,Bloom CE,Kirchenbaum GA,Tsvetnitsky V,Isakova-Sivak I,Rudenko L,Ross TM

更新日期：2015-01-01 00:00:00