Identification of murine T-cell epitopes on low-molecular-mass secretory proteins (CFP11, CFP17, and TB18.5) of Mycobacterium tuberculosis.

abstract：:Based on the reactivities of monoclonal antibodies, we previously reported that 25 Japanese encephalitis (JE) virus strains fell into five antigenic groups: Nakayama, Beijing-1, Kamiyama, 691004 and Muar. In the present study, we produced monoclonal antibodies against the Beijing-1 strain and obtained the Beijing-1 gr...

journal_title：Vaccine

authors： Satake Y,Hasegawa H,Yoshida M,Kobayashi Y

更新日期：1994-06-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides containing CpG immunostimulatory sequences (ISS) have been shown to act as potent adjuvants of type 1 immune responses when co-administered with protein or peptide vaccines. We have recently shown that ISS can increase the anti-polysaccharide (CHO) and anti-tetanus toxoid (TT) or anti-d...

journal_title：Vaccine

authors： von Hunolstein C,Mariotti S,Teloni R,Alfarone G,Romagnoli G,Orefici G,Nisini R

更新日期：2001-04-30 00:00:00

abstract：:Vaccination is considered the most cost-effective approach to preventing infectious diseases, yet better formulations and delivery methods for efficient distribution and administration of vaccines are needed, especially for low-resource settings. A fast-dissolving tablet (FDT) that could be packaged in a compact stack...

journal_title：Vaccine

authors： Lal M,Priddy S,Bourgeois L,Walker R,Pebley W,Brown J,Desai J,Darsley MJ,Kristensen D,Chen D

更新日期：2013-10-01 00:00:00

abstract：:Fluid cholera vaccine was examined for its stability at 4-8 degrees C, 20-25 degrees C and 37 degrees C with regard to the number of organisms present and the total nitrogen content. Ten batches of fluid cholera vaccine manufactured at the Central Research Institute, Kasauli, India were taken for the study. The number...

journal_title：Vaccine

authors： Gupta RK,Maheshwari SC,Sharma SB,Ahuja S,Saxena SN

更新日期：1984-12-01 00:00:00

abstract：:A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...

journal_title：Vaccine

authors： Satterthwait AC,Arrhenius T,Hagopian RA,Zavala F,Nussenzweig V,Lerner RA

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Trans-placentally acquired antibodies can protect infants from infection in the first months of life. However, high concentrations of antibody at birth may impact the infant's own immune response to primary immunization. We examine the relationship between concentration of specific antibody to Borde...

journal_title：Vaccine

authors： Jones C,Pollock L,Barnett SM,Battersby A,Kampmann B

更新日期：2014-02-12 00:00:00

abstract：:Cellular as well as humoral immune reactivity were studied in healthy young (< 30 years; n = 12) and older (> 65 years; n = 12) individuals before as well as 1 month after immunization with a trivalent whole virus influenza vaccine. Before vaccination, peripheral blood mononuclear cell proliferation in response to in ...

journal_title：Vaccine

authors： Saurwein-Teissl M,Steger MM,Glück R,Cryz S,Grubeck-Loebenstein B

更新日期：1998-01-01 00:00:00

abstract：:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...

journal_title：Vaccine

authors： Edmunds WJ,Brisson M,Melegaro A,Gay NJ

更新日期：2002-01-31 00:00:00

abstract：:Longitudinal serum samples were collected from 542 children that had participated in a Swedish pertussis vaccine trial 1992-1995 [Gustafsson L, Hallander HO, Olin P, Reizenstein E, Storsaeter J. A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Me...

journal_title：Vaccine

authors： Hallander HO,Gustafsson L,Ljungman M,Storsaeter J

更新日期：2005-11-16 00:00:00

abstract：:CD1d-binding glycolipids exert potent adjuvant effects on T-dependent Ab responses. The mechanisms include cognate interaction between CD1d-expressing B cells and TCR-expressing Type I CD1d-restricted natural killer T cells (NKTs). However, the critical NKT-derived factors that stimulate B cells are poorly understood....

journal_title：Vaccine

authors： Shah HB,Joshi SK,Lang ML

更新日期：2011-11-15 00:00:00

abstract：:T-lymphocyte responses to influenza vaccination were measured in healthy young and older adult volunteers. All participants were vaccinated with the 1995-96 trivalent influenza vaccine. Cytokine and granzyme B levels were measured in peripheral blood mononuclear cells (PBMC) cultures after virus stimulation, prior to ...

journal_title：Vaccine

authors： McElhaney JE,Upshaw CM,Hooton JW,Lechelt KE,Meneilly GS

更新日期：1998-11-01 00:00:00

abstract：:Mutations arising in neutralizing epitopes of hepatitis C virus may play a role in the ability of the virus to escape control by neutralizing antibodies and in the establishment of chronic infections. An amino-acid substitution, Q412H, within a major conserved neutralization epitope EP I (aa 412-426) in the E2 glycopr...

journal_title：Vaccine

authors： Duan H,Struble E,Zhong L,Mihalik K,Major M,Zhang P,Feinstone S,Feigelstock D

更新日期：2010-06-07 00:00:00

abstract：:Like any biotechnology innovation, the production of human vaccines in plants will succeed partly on its technical merits, and partly on the social acceptance of the new technology. The latter is harder to predict than the former, and may pose the most significant challenges to plant-derived vaccines' (PDVs) success. ...

journal_title：Vaccine

authors： Castle D,Dalgleish J

更新日期：2005-03-07 00:00:00

abstract：BACKGROUND:FP-01.1 is a novel synthetic influenza A vaccine consisting of six fluorocarbon-modified 35-mer peptides that encapsulate multiple CD4+ and CD8+ T-cell epitopes and is designed to induce an immune response across a broad population. METHODS:FP-01.1 was evaluated for safety and immunogenicity in a randomised...

journal_title：Vaccine

authors： Francis JN,Bunce CJ,Horlock C,Watson JM,Warrington SJ,Georges B,Brown CB

更新日期：2015-01-03 00:00:00

abstract：:The neutralising antibody response after the yellow fever vaccine (YF-17D) skin test was measured in 7 egg allergic persons in whom further vaccination was abandoned because of a strong local urticarial reaction to the YF-17D vaccine test dose. We found that this test dose of 0.1mL of YF-17D vaccine was sufficient to ...

journal_title：Vaccine

authors： Roukens AH,Vossen AC,van Dissel JT,Visser LG

更新日期：2009-04-21 00:00:00

abstract：:Immunization with a combination of several virulence-associated proteins is one of the strategies of developing effective protein-based vaccines to enhance the protection against Streptococcus pneumoniae. In this study, we evaluated the protection effects against pneumococcal infection caused by S. pneumoniae TIGR4 in...

journal_title：Vaccine

authors： Cao J,Chen D,Xu W,Chen T,Xu S,Luo J,Zhao Q,Liu B,Wang D,Zhang X,Shan Y,Yin Y

更新日期：2007-06-28 00:00:00

abstract：:The Global Meningococcal Initiative (GMI) is composed of an international group of scientists, clinicians and public health officials with expertise in meningococcal immunology, epidemiology and prevention. The primary goal of the GMI is the promotion of the global prevention of invasive meningococcal disease through ...

journal_title：Vaccine

authors： Harrison LH,Pelton SI,Wilder-Smith A,Holst J,Safadi MA,Vazquez JA,Taha MK,LaForce FM,von Gottberg A,Borrow R,Plotkin SA

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:Rabies is a neglected zoonotic disease with a global burden of approximately 59,000 human deaths a year. Once clinical symptoms appear, rabies is almost invariably fatal; however, with timely and appropriate post-exposure prophylaxis (PEP) consisting of wound washing, vaccine, and in some cases rabies immuno...

journal_title：Vaccine

authors： Sreenivasan N,Li A,Shiferaw M,Tran CH,Wallace R,Blanton J,Knopf L,Abela-Ridder B,Hyde T,Working group on Rabies PEP logistics.

更新日期：2019-10-03 00:00:00

abstract：:The Indian rhesus macaque is the established animal model for HIV infection and vaccine research. Growing evidence suggests that the more readily available Chinese rhesus macaque may be a more relevant option. As increasing numbers of novel Chinese rhesus MHC alleles are reported, we decided to explore potential HIV v...

journal_title：Vaccine

authors： Liao Q,Strong AJ,Liu Y,Liu Y,Meng P,Fu Y,Touzjian N,Shao Y,Zhao Z,Lu Y

更新日期：2012-02-21 00:00:00

abstract：:Bordetella pertussis is the etiologic agent of whooping cough, an illness whose incidence has been increasing over the last decades. Pertussis reemergence despite high vaccination coverage, together with the recent isolation of circulating strains deficient in some of the vaccine antigens, highlight the need for new v...

journal_title：Vaccine

authors： Alvarez Hayes J,Erben E,Lamberti Y,Principi G,Maschi F,Ayala M,Rodriguez ME

更新日期：2013-08-02 00:00:00

abstract：:An ELISA-immunocapture assay was developed for quantification of influenza neuraminidases (N2 and B), with a sensitivity about 10 ng neuramidase(NA)/ml. This sensitive and specific assay was applied to several trivalent vaccine preparations (1997/1998 and 1998/1999). It was shown capable to detect 3.5-6.9 microg NA/ml...

journal_title：Vaccine

authors： Aymard M

更新日期：2002-05-15 00:00:00

abstract：:A third of the world population is latently infected with Mycobacterium tuberculosis and many cases of active tuberculosis arise from latent bacilli reactivation. Thus, it is important to design new vaccines to prevent reactivation. Using an experimental model of chronic tuberculosis in B6D2F1 mice, we observed consta...

journal_title：Vaccine

authors： Campuzano J,Aguilar D,Arriaga K,León JC,Salas-Rangel LP,González-y-Merchand J,Hernández-Pando R,Espitia C

更新日期：2007-05-04 00:00:00

abstract：:Gag-CD8+ T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Delta4 Nef+), creating Delta5 Nef(-), would affect its immunogenicity. When compared with Delta4, mice inje...

journal_title：Vaccine

authors： Arrode G,Hegde R,Jin Y,Singh DK,Narayan O,Chebloune Y

更新日期：2008-07-23 00:00:00

abstract：:We vaccinated 15 persons, age 56 to 79 years, with 14-valent pneumococcal polysaccharide vaccine and revaccinated them with 23-valent vaccine 6 years later to assess adverse reactions and booster responses of anticapsular antibodies. No systemic reactions occurred after administration of either vaccine. After booster ...

journal_title：Vaccine

authors： Mufson MA,Hughey DF,Turner CE,Schiffman G

更新日期：1991-06-01 00:00:00

abstract：:A major impediment to the development of peptide vaccines has been the inability accurately to mimic conformationally constrained epitopes on the envelope proteins of pathogens. This limitation is further compounded by the fact that several viral envelope proteins exist either as covalently or non-covalently associate...

journal_title：Vaccine

authors： Rao KV,Panda SK,Manivel V

更新日期：1992-01-01 00:00:00

abstract：:By using a baculovirus expression system, we have successfully produced simian immunodeficiency virus (SIV)-like particles (VLPs) with high levels of biologically active SIV envelope (Env) incorporated on their surfaces. To study whether SIV VLPs represent effective mucosal immunogens, we immunized groups of mice with...

journal_title：Vaccine

authors： Yao Q,Vuong V,Li M,Compans RW

更新日期：2002-06-07 00:00:00

abstract：:Breast milk (colostrum [col]/milk) components and gut commensals play important roles in neonatal immune maturation, establishment of gut homeostasis and immune responses to enteric pathogens and oral vaccines. We investigated the impact of colonization by probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacteri...

journal_title：Vaccine

authors： Chattha KS,Vlasova AN,Kandasamy S,Esseili MA,Siegismund C,Rajashekara G,Saif LJ

更新日期：2013-04-08 00:00:00

abstract：BACKGROUND:Streptococcus pyogenes (group A Streptococcus, Strep A) is a widespread pathogen that continues to pose a significant threat to human health. The development of a Strep A vaccine remains an unmet global health need. One of the major vaccine strategies is the use of M protein, which is a primary virulence det...

journal_title：Vaccine

authors： Pastural É,McNeil SA,MacKinnon-Cameron D,Ye L,Langley JM,Stewart R,Martin LH,Hurley GJ,Salehi S,Penfound TA,Halperin S,Dale JB

更新日期：2020-02-05 00:00:00

abstract：:We previously described that an inactivated vaccine against heartwater prepared from Cowdria ruminantium (Crystal Springs strain) organisms and administered in complete Freund's adjuvant (cFA) protected sheep against homologous needle challenge. Further studies, described herein, demonstrated that this vaccine protect...

journal_title：Vaccine

authors： Mahan SM,Kumbula D,Burridge MJ,Barbet AF

更新日期：1998-07-01 00:00:00

abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

journal_title：Vaccine

authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

更新日期：2019-01-03 00:00:00