Conformational restriction of peptidyl immunogens with covalent replacements for the hydrogen bond.

abstract：:The Global Meningococcal Initiative (GMI) is composed of an international group of scientists, clinicians and public health officials with expertise in meningococcal immunology, epidemiology and prevention. The primary goal of the GMI is the promotion of the global prevention of invasive meningococcal disease through ...

journal_title：Vaccine

authors： Harrison LH,Pelton SI,Wilder-Smith A,Holst J,Safadi MA,Vazquez JA,Taha MK,LaForce FM,von Gottberg A,Borrow R,Plotkin SA

更新日期：2011-04-18 00:00:00

abstract：:According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp12...

journal_title：Vaccine

authors： Metlas R,Veljković V

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:Yearly vaccination against influenza is currently recommended to patients with rheumatoid Arthritis (RA). Antibody and cell-mediated responses are both involved in the defense against influenza. Humoral responses to influenza vaccine are impaired in RA patients treated with rituximab (RTX). The objectives of...

journal_title：Vaccine

authors： Arad U,Tzadok S,Amir S,Mandelboim M,Mendelson E,Wigler I,Sarbagil-Maman H,Paran D,Caspi D,Elkayam O

更新日期：2011-02-11 00:00:00

abstract：:Infectious bronchitis virus (IBV) as an avian coronavirus is still posing a persistent and imminent threat to the poultry industry worldwide. Here we report that transfection of Sf9 cells with a single recombinant baculovirus encoding M and S proteins resulted in the assembly of IBV VLPs; this is the first report that...

journal_title：Vaccine

authors： Liu G,Lv L,Yin L,Li X,Luo D,Liu K,Xue C,Cao Y

更新日期：2013-11-12 00:00:00

abstract：:This review considers possible reasons behind parents' missed vaccination opportunities in the context of the latest immunisation coverage rates for England. Suboptimal uptake is not exclusive to measles, mumps and rubella (MMR). A substantial proportion of children also miss diphtheria, tetanus and polio vaccination....

journal_title：Vaccine

authors： Tickner S,Leman PJ,Woodcock A

更新日期：2006-11-30 00:00:00

abstract：:Bovine tuberculosis (bTB) is increasing in incidence in the UK. Effective control strategies could involve vaccination; BCG, either alone or in prime-boost strategies, remains the most effective vaccine against bovine tuberculosis. However, BCG vaccination of cattle would require development of diagnostic tests able t...

journal_title：Vaccine

authors： Sopp P,Coad M,Hewinson G,Howard CJ,Cheallaigh CN,Keane J,Harris J,Hope JC

更新日期：2008-10-09 00:00:00

abstract：:New and improved vaccines and delivery systems are increasingly being developed for prevention, treatment and diagnosis of human diseases. Prior to their use in humans, all new biological products must undergo pre-clinical evaluation. These pre-clinical studies are important not only to establish the biological proper...

journal_title：Vaccine

authors： Sesardic D

更新日期：2006-04-12 00:00:00

abstract：:Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvan...

journal_title：Vaccine

authors： Xiong Q,Wei Y,Xie H,Feng Z,Gan Y,Wang C,Liu M,Bai F,Xie F,Shao G

更新日期：2014-06-05 00:00:00

abstract：:Reconstituted influenza virus (A/PR/8 strain) envelopes (RIVE) and influenza virus (A/Sichuan/87 (H3N2) strain) surface antigens were entrapped in dehydration-rehydration vesicles (DRV liposomes) composed of egg phosphatidylcholine (PC) or distearoyl phosphatidylcholine (DSPC DRV) and equimolar (32 mumol) cholesterol....

journal_title：Vaccine

authors： Gregoriadis G,Tan L,Ben-Ahmeida ET,Jennings R

更新日期：1992-01-01 00:00:00

abstract：:Gamma inulin and Algammulin, two new adjuvants, were examined and compared with alum and Freund's Complete/Incomplete Adjuvant (FCA/FIA), for potentiation of cell-mediated immunity (CMI) and humoral immunity in sheep to a recombinant Taenia ovis antigen. The ability to protect sheep when challenged with live T. ovis e...

journal_title：Vaccine

authors： Deol HS,Palmer DG,Dunsmore T,Carnegie PR

更新日期：1995-04-01 00:00:00

abstract：:Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing ...

journal_title：Vaccine

authors： Moreland NJ,Waddington CS,Williamson DA,Sriskandan S,Smeesters PR,Proft T,Steer AC,Walker MJ,Baker EN,Baker MG,Lennon D,Dunbar R,Carapetis J,Fraser JD

更新日期：2014-06-24 00:00:00

abstract：:Epitopes in HIV polymerase were analyzed by peptide binding to human leukocyte antigen (HLA) A0201 molecules, the most frequent HLA class in the Caucasian population. We found that HIV-1 protease peptides representing both the wild type and anticipated drug resistance variants of the sequence bound well to HLA-A0201. ...

journal_title：Vaccine

authors： Boberg A,Sjöstrand D,Rollman E,Hinkula J,Zuber B,Wahren B

更新日期：2006-05-22 00:00:00

abstract：:Norovirus (NoV) and hepatitis E virus (HEV) are both enterically-transmitted viruses causing gastroenteritis and hepatitis, respectively, in humans. While a vaccine against HEVs recently became available in China, there is no prophylactic or therapeutic approach against NoVs. Both NoV and HEV have surface protrusions ...

journal_title：Vaccine

authors： Wang L,Cao D,Wei C,Meng XJ,Jiang X,Tan M

更新日期：2014-01-16 00:00:00

abstract：:For the production of a chemically inactivated Parapoxvirus ovis (PPVO), an adherent bovine kidney cell line was cultivated on Cytodex-3 microcarriers in suspension culture. The inactivated and purified virus particles have shown immune modulatory activity in several animal models. PPVO was produced by a biphasic batc...

journal_title：Vaccine

authors： Pohlscheidt M,Langer U,Minuth T,Bödeker B,Apeler H,Hörlein HD,Paulsen D,Rübsamen-Waigmann H,Henzler HJ,Reichl U

更新日期：2008-03-17 00:00:00

abstract：:Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection in macaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B v...

journal_title：Vaccine

authors： Loomis-Huff JE,Eberle R,Lockridge KM,Rhodes G,Barry PA

更新日期：2001-09-14 00:00:00

abstract：:The use of gene guns in ballistically delivering DNA vaccine coated gold micro-particles to skin can potentially damage targeted cells, therefore influencing transfection efficiencies. In this paper, we assess cell death in the viable epidermis by non-invasive near infrared two-photon microscopy following micro-partic...

journal_title：Vaccine

authors： Raju PA,McSloy N,Truong NK,Kendall MA

更新日期：2006-05-22 00:00:00

abstract：:The safety and immunogenicity of two PorA-based meningococcal outer membrane vesicle (OMV) vaccines against the P1.4 serosubtype adsorbed with AlPO(4) or Al(OH)(3) were studied in 134 toddlers. Vaccinations were given three times with an interval of 3-6 weeks or twice with an interval of 6-10 weeks. A vaccination was ...

journal_title：Vaccine

authors： de Kleijn ED,de Groot R,Lafeber AB,Labadie J,van Limpt KC,Visser J,Berbers GA,van Alphen L,Rümke HC

更新日期：2000-12-08 00:00:00

abstract：BACKGROUND:The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishi...

journal_title：Vaccine

authors： Nelson NP,Yankey D,Singleton JA,Elam-Evans LD

更新日期：2018-03-14 00:00:00

abstract：INTRODUCTION:Intramuscular Immune Serum Globulin (IM ISG) is recommended as post-measles exposure prophylaxis (PEP) when administered within 6days of initial exposure, with variable effectiveness in preventing measles disease. Effectiveness of IM ISG PEP in preventing clinical measles was assessed during a 2014 measles...

journal_title：Vaccine

authors： Bigham M,Murti M,Fung C,Hemming F,Loadman S,Stam R,Van Buynder P,Lem M

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:Theories of health behavior change are being inadequately adopted to understand the reasons behind low influenza vaccination rates among healthcare workers (HCWs). The Theory of Planned Behavior (TPB) is being used to predict intention-behavior relationship while the Health Belief Model (HBM) is being employ...

journal_title：Vaccine

authors： Alhalaseh L,Fayoumi H,Khalil B

更新日期：2020-10-27 00:00:00

abstract：:Human respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease and hospitalizations in infants and young children. It also causes significant morbidity and mortality in elderly and immune compromised individuals. No licensed vaccine currently exists. Parainfluenza virus 5 (PIV5) is a paramyxo...

journal_title：Vaccine

authors： Phan SI,Chen Z,Xu P,Li Z,Gao X,Foster SL,Teng MN,Tripp RA,Sakamoto K,He B

更新日期：2014-05-23 00:00:00

abstract：:The spike peplomer S1 subunit sequence from avian infectious bronchitis virus (IBV) Vic S strain was expressed in a plasmid under the control of the fowl adenovirus (FAV) major late promoter (MLP). Two recombinants were constructed in FAV serotype 8 (FAV 8) by inserting the expression cassette between the SnaBI and Xb...

journal_title：Vaccine

authors： Johnson MA,Pooley C,Ignjatovic J,Tyack SG

更新日期：2003-06-20 00:00:00

abstract：:In Autumn 1990, trivalent split influenza virus vaccine containing A/Taiwan/1/86(H1N1) was used to immunize healthy female employees (n = 104). The 11-12 amino acid differences in the HA1 domain of virus haemagglutinin between A/Taiwan/1/86 and representative epidemic H1N1 strains in Finland in 1991 did not result in ...

journal_title：Vaccine

authors： Pyhälä R,Kinnunen L,Kumpulainen V,Ikonen N,Kleemola M,Cantell K

更新日期：1993-01-01 00:00:00

abstract：:This paper briefly reviews work on vaccine development since the early 1950s with special emphasis on identification of immunogens and their presentation to the host so as to elicit an immune response. This is illustrated primarily by a discussion of the development of a candidate meningococcal B vaccine based on a ca...

journal_title：Vaccine

authors： Beale AJ

更新日期：1988-04-01 00:00:00

abstract：:Age related deterioration in the function of the immune system has been recognised in many species. The clinical presentations of such immune dysfunction are an age-related increased susceptibility to certain infections, and an increased incidence of autoimmune disease and certain cancers. Laboratory investigations re...

journal_title：Vaccine

authors： Aspinall R,Andrew D

更新日期：2000-02-25 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：:With declining influenza vaccine coverage in the elderly in recent years in France, we aimed at assessing the benefits of seasonal influenza vaccination, based on available data for observed mortality, vaccine coverage and vaccine effectiveness. To estimate the annual number of deaths avoided by vaccination in the peo...

journal_title：Vaccine

authors： Bonmarin I,Belchior E,Lévy-Bruhl D

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:To block transmission of measles, the China Ministry of Health endorsed the "2006-2012 National Measles Elimination Action Plan (NMEAP)" on November 11, 2006, while no published studies used mathematical models to assess the impact of this action. Also, the problem of residuals autocorrelation due to auto-co...

journal_title：Vaccine

authors： Xu L,Chen J,Zhan Z,Chen T,Liu W,Qian J,Ou C

更新日期：2020-06-09 00:00:00

abstract：:Bovine herpesvirus-1 (BHV-1) glycoprotein D (gD), an envelope glycoprotein, engenders mucosal and systemic immunity protecting cattle from viral infection. Production of gD with authentic immunogenicity is required for a subunit vaccine. We placed the truncated BHV-1 gD gene, lacking its putative transmembrane and cyt...

journal_title：Vaccine

authors： Zhu X,Wu S,Letchworth GJ 3rd

更新日期：1997-04-01 00:00:00

abstract：:We recently developed a novel immunomodulating gene fusion protein, CTA1-DD, that combines the ADP-ribosylating ability of cholera toxin (CT) with a dimer of an Ig-binding fragment, D, of Staphylococcus aureus protein A. The CTA1-DD adjuvant was found to be non-toxic and greatly augmented T cell dependent and independ...

journal_title：Vaccine

authors： Lycke N,Schön K

更新日期：2001-03-21 00:00:00