Abstract:
:With declining influenza vaccine coverage in the elderly in recent years in France, we aimed at assessing the benefits of seasonal influenza vaccination, based on available data for observed mortality, vaccine coverage and vaccine effectiveness. To estimate the annual number of deaths avoided by vaccination in the people aged 65 years or more, we used the following three elements: an estimate of vaccine effectiveness against all-cause mortality (based on the "difference-in-differences" approach which reduces the usual bias seen in observational studies), French mortality data and vaccine coverage data. We estimated an annual average of 2000 deaths currently avoided through vaccination and a vaccine effectiveness of 35% against influenza-attributable deaths. Around 2650 vaccinations are needed to prevent a death among the elderly. Communicating these results should help restoring at-risk populations' confidence in influenza vaccination.
journal_name
Vaccinejournal_title
Vaccineauthors
Bonmarin I,Belchior E,Lévy-Bruhl Ddoi
10.1016/j.vaccine.2015.01.023subject
Has Abstractpub_date
2015-02-25 00:00:00pages
1099-101issue
9eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)00042-0journal_volume
33pub_type
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