Abstract：
:Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in about 150,000 individuals in Eurasia, and several hundred cases of hantavirus pulmonary syndrome (HPS) on the American continent annually. There is consequently a need for rapid diagnostics and effective prevention of hantaviral infections. In this study we have performed DNA-vaccination of mice with full-length genes encoding the immunogenic nucleocapsid protein (NP) of Puumala (PUUV), Seoul (SEOV) and Sin Nombre virus (SNV). The antibody reactivity towards the NPs, and deleted or truncated variants thereof, were studied to localise and investigate the major polyclonal B-cell epitopes. Our findings clearly show that the antibody reactivity in each immunised mouse is unique, not only in a quantitative respect (titers) but also in cross-reactivity and most likely also in the epitope specificity. Our experimental data in combination with B-cell prediction software indicate that strong homologous virus species specific and cross-reactive epitopes are located around amino acid residue 40 in the nucleocapsid proteins.
journal_name
Vaccinejournal_title
Vaccineauthors
Lindkvist M,Lahti K,Lilliehöök B,Holmström A,Ahlm C,Bucht Gdoi
10.1016/j.vaccine.2006.09.082subject
Has Abstractpub_date
2007-02-19 00:00:00pages
1690-9issue
9eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)01070-Xjournal_volume
25pub_type
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