Safety and immunogenicity of prepandemic H5N1 influenza vaccines: a systematic review of the literature.

abstract：BACKGROUND:Unbiased deep sequencing offers the potential for improved adventitious virus screening in vaccines and biotherapeutics. Successful implementation of such assays will require appropriate control materials to confirm assay performance and sensitivity. METHODS:A common reference material containing 25 target ...

journal_title：Vaccine

authors： Mee ET,Preston MD,Minor PD,Schepelmann S,CS533 Study Participants.

更新日期：2016-04-12 00:00:00

abstract：:Serotype-specific protective immunity in pediatric patients with invasive pneumococcal disease (IPD) has not been fully investigated. To determine the protective immunity to the infecting serotype, the serotype-specific immunoglobulin G (IgG) levels and opsonization indices (OIs) were examined in 24 Japanese pediatric...

journal_title：Vaccine

authors： Oishi T,Ishiwada N,Matsubara K,Nishi J,Chang B,Tamura K,Akeda Y,Ihara T,Nahm MH,Oishi K,Japanese IPD Study Group.

更新日期：2013-01-21 00:00:00

abstract：:In order to perform preliminary evaluations of subunit vaccine candidates before extensive trials in large food-producing animals, an in vitro B-lymphocyte response assay, based on the principles of an ELISA, was established. The assay was developed in detail for the porcine system using antigens from the Gram-negativ...

journal_title：Vaccine

authors： Ohmann HB,McDougall L,Potter A

更新日期：1991-03-01 00:00:00

abstract：:The reactogenicity and immunogenicity of the administration of recombinant vaccine against hepatitis B simultaneously (but at separate sites) with diphtheria/tetanus/pertussis (DTP) and oral polio vaccines were examined. Six hundred and twenty-six children (group I) were given hepatitis B vaccine at 0, 2 and 6 months ...

journal_title：Vaccine

authors： Aristegui J,Muñiz J,Pérez Legorburu A,Imaz M,Arrate JP,Suárez MD,Goiri MD

更新日期：1995-08-01 00:00:00

abstract：:Gram-negative bacterial outer membrane proteins (Omps) have an important role in pathogenesis and signal reception. We previously reported that Acinetobacter OmpA (AbOmpA) induced maturation of bone marrow-derived dendritic cells (BMDCs) and that AbOmpA-primed DCs produced IL-12 which generated Th1 CD4(+) T-cells. We ...

journal_title：Vaccine

authors： Jang MJ,Kim JE,Chung YH,Lee WB,Shin YK,Lee JS,Kim D,Park YM

更新日期：2011-03-16 00:00:00

abstract：:The purpose of the NIAID/FDA joint workshop, "correlates of immunity for pneumococcal conjugate vaccines (PCVs)," was to discuss the present understanding of protective immunity against invasive pneumococcal disease and identify in vitro measures that may represent immunologic correlates in future clinical trials. Ani...

journal_title：Vaccine

authors： Lee LH,Frasch CE,Falk LA,Klein DL,Deal CD

更新日期：2003-05-16 00:00:00

abstract：BACKGROUND:In France, midwives have recently been authorized to administer various vaccines to women (including pregnant women), newborns, and their family members. This is expected to enhance vaccine coverage. However, the French high level of vaccine hesitancy is also observed in some healthcare workers. We thus aime...

journal_title：Vaccine

authors： Massot E,Epaulard O

更新日期：2018-08-16 00:00:00

abstract：OBJECTIVE:This study sought to evaluate the acceptability of inactivated influenza vaccine delivered by microneedle patch (MNP) in comparison to inactivated influenza vaccine (IIV) delivered by hypodermic needle. DESIGN, SETTING, AND PARTICIPANTS:From the general population of Atlanta, Georgia, we screened 112 and enr...

journal_title：Vaccine

authors： Frew PM,Paine MB,Rouphael N,Schamel J,Chung Y,Mulligan MJ,Prausnitz MR

更新日期：2020-10-21 00:00:00

abstract：:Estimation of the full disease burden caused by Streptococcus pneumoniae is challenging due to the difficulties in assigning the aetiology especially in lower and upper respiratory infections. We estimated the pneumococcal disease burden by using the vaccine-preventable disease incidence (VPDI) of PHiD-CV10 vaccine (G...

journal_title：Vaccine

authors： Palmu AA,Jokinen J,Nieminen H,Rinta-Kokko H,Ruokokoski E,Puumalainen T,Moreira M,Schuerman L,Borys D,Kilpi TM

更新日期：2018-03-27 00:00:00

abstract：:The shelf life and thermal stability of an antifertility vaccine, in which gonadotropin subunits are linked to carriers such as tetanus toxoid and cholera toxin chain B and has successfully completed phase-I clinical trials at five centres in India, was studied. The vaccine adsorbed on alum was stored at three tempera...

journal_title：Vaccine

authors： Alam A,Singh O,Talwar GP

更新日期：1989-04-01 00:00:00

abstract：:Vaccine development strategies have often utilized recombinant envelope glycoproteins which usually generate strong humoral immune responses but which do not generate strong cytotoxic T lymphocytes (CTL). A recent novel experimental vaccination approach involves the technology known as nucleic acid immunization in whi...

journal_title：Vaccine

authors： Ugen KE,Boyer JD,Wang B,Bagarazzi M,Javadian A,Frost P,Merva MM,Agadjanyan MG,Nyland S,Williams WV,Coney L,Ciccarelli R,Weiner DB

更新日期：1997-06-01 00:00:00

abstract：:A recombinant fowlpox vaccine with an H5 hemagglutinin gene insert protected chickens against clinical signs and death following challenge by nine different highly pathogenic H5 avian influenza viruses. The challenge viruses had 87.3 to 100% deduced hemagglutinin amino acid sequence similarity with the recombinant vac...

journal_title：Vaccine

authors： Swayne DE,Garcia M,Beck JR,Kinney N,Suarez DL

更新日期：2000-01-06 00:00:00

abstract：:Hepatitis A vaccine is recommended for all individuals with hemophilia, although patients with bleeding disorders should avoid intramuscular (IM) injections. To date, only few studies showed subcutaneous (SC) route immunogenicity is comparable with the IM route. Therefore, this randomized study compared immunogenicity...

journal_title：Vaccine

authors： Nakasone M,Lopes MH,Sartori AMC,Sandoval EPN,Villaça PR,D'Amico EA,Carneiro JDA

更新日期：2020-05-27 00:00:00

abstract：:Carbopol is a polyanionic carbomer used in man for topical application and drug delivery purposes. However parenteral administration of Carbopol in animal models results in systemic adjuvant activity including strong pro-inflammatory type-1 T-cell (Th1) polarization. Here we investigated potential pathways of immune a...

journal_title：Vaccine

authors： Gartlan KH,Krashias G,Wegmann F,Hillson WR,Scherer EM,Greenberg PD,Eisenbarth SC,Moghaddam AE,Sattentau QJ

更新日期：2016-04-27 00:00:00

abstract：:The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902)...

journal_title：Vaccine

authors： Roestenberg M,Mo A,Kremsner PG,Yazdanbakhsh M

更新日期：2017-12-18 00:00:00

abstract：:A human influenza B/Lee/40 virus was cold-adapted by serial passages in embryonated chicken eggs, at progressively lower temperatures, for possible use as a future influenza B vaccine donor strain. Temperature sensitive and cold-adapted phenotypes were achieved as a consequence of the adaptation process. It was determ...

journal_title：Vaccine

authors： Seo SU,Byun YH,Lee EY,Jung EJ,Jang YH,Kim HA,Ha SH,Lee KH,Seong BL

更新日期：2008-02-13 00:00:00

abstract：:Human intestinal infections with the nematode Strongyloides stercoralis remain a significant problem worldwide and a vaccine would be a useful addition to the tools available to prevent and control this infection. The goal of this study was to test single antigens for their efficacy in a vaccine against S. stercoralis...

journal_title：Vaccine

authors： Abraham D,Hess JA,Mejia R,Nolan TJ,Lok JB,Lustigman S,Nutman TB

更新日期：2011-10-19 00:00:00

abstract：:A new rabies vaccine was developed from Vero cells adhered to microcarriers, cultivated in a bioreactor in serum-free medium and infected with the PV/VERO-Paris rabies virus strain. The viral suspensions were concentrated by tangential filtration, purified by chromatography and inactivated with beta-propiolactone. In ...

journal_title：Vaccine

authors： Frazatti-Gallina NM,Mourão-Fuches RM,Paoli RL,Silva ML,Miyaki C,Valentini EJ,Raw I,Higashi HG

更新日期：2004-12-09 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is the major viral cause of infant and childhood lower respiratory tract disease worldwide. Defining the optimal target product profile (TPP) is complicated due to a wide range of possible vaccine properties, modalities and an incomplete understanding of the mechanism of nat...

journal_title：Vaccine

authors： Pan-Ngum W,Kinyanjui T,Kiti M,Taylor S,Toussaint JF,Saralamba S,Van Effelterre T,Nokes DJ,White LJ

更新日期：2017-01-05 00:00:00

abstract：:Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect ...

journal_title：Vaccine

authors： Clements A,Jenney AW,Farn JL,Brown LE,Deliyannis G,Hartland EL,Pearse MJ,Maloney MB,Wesselingh SL,Wijburg OL,Strugnell RA

更新日期：2008-10-16 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus nucleocapsid protein (SARS-CoV N) is one of the major targets for SARS vaccine due to its high potency in triggering immune responses. In this study, we have identified a novel HLA-A*0201 restricted epitope, N220 (LALLLLDRL), of the SARS-CoV N-protein through bioinform...

journal_title：Vaccine

authors： Cheung YK,Cheng SC,Sin FW,Chan KT,Xie Y

更新日期：2007-08-10 00:00:00

abstract：:Pneumococcal conjugate vaccines (PCV) may reduce nasopharyngeal carriage (NPC) of Streptococcus pneumoniae vaccine strains (VT), but serotype replacement with non-vaccine strains (NVT) has been reported. Bacterial NPC after PHiD-CV vaccination was assessed in the second year of life. Open descriptive study of NPC repo...

journal_title：Vaccine

authors： Prymula R,Hanovcova I,Splino M,Kriz P,Motlova J,Lebedova V,Lommel P,Kaliskova E,Pascal T,Borys D,Schuerman L

更新日期：2011-02-24 00:00:00

abstract：:Pertactin/P.69, a surface-associated polypeptide antigen of Bordetella pertussis, was expressed in a Salmonella typhimurium aroA aroD vaccine strain, BRD509, using different expression systems, and the immune response in mice against these constructs was compared. Initially, Pertactin/P.69 was expressed on the surface...

journal_title：Vaccine

authors： Anderson R,Dougan G,Roberts M

更新日期：1996-10-01 00:00:00

abstract：:Currently, commercial porcine rotavirus vaccines remain varied limitations. The objective of this study is to develop an alternative porcine rotavirus subunit vaccine candidate by parenteral administration, which enables to elicit robust immune responses against most prevalence porcine rotavirus strains. The bacterial...

journal_title：Vaccine

authors： Wen X,Wei X,Ran X,Ni H,Cao S,Zhang Y

更新日期：2015-08-26 00:00:00

abstract：:Bacterially-displayed peptide libraries have been widely used as an alternative to phage-displayed peptide libraries in screening epitopes or mimotopes of antibodies. Using a protective monoclonal antibody (mAb) 3B9 against hepatitis B virus (HBV) preS protein as target, mimotopes were successfully screened from a Fli...

journal_title：Vaccine

authors： Xin ZT,Liu C,Gao YP,Mao CQ,Zhao A,Zhang J,Shao NS,Ling SG,Xue YN

更新日期：2003-10-01 00:00:00

abstract：:The study evaluated the immunogenicity and efficacy of a trivalent subunit MF59-adjuvanted influenza vaccine (A/Wisconsin/67/05 (H3N2), A/Solomon Islands/3/06 (H1N1) and B/Malaysia/2506/04) in preventing serologically diagnosed infections in a group of 67 institutionalized elderly volunteers during 2007/2008 winter, c...

journal_title：Vaccine

authors： Camilloni B,Neri M,Lepri E,Basileo M,Sigismondi N,Puzelli S,Donatelli I,Iorio AM

更新日期：2010-11-03 00:00:00

abstract：BACKGROUND:Each year, approximately 1,066 Cambodian children under five years old die of diarrhea, and 51% of these deaths are due to rotavirus gastroenteritis. Quantifying childhood hospitalizations caused by severe rotavirus infections is also important in demonstrating disease burden caused by this virus. The object...

journal_title：Vaccine

authors： Angkeabos N,Rin E,Vichit O,Chea C,Tech N,Payne DC,Fox K,Heffelfinger JD,Grabovac V,Nyambat B,Diorditsa S,Samnang C,Hossain MS

更新日期：2018-12-14 00:00:00

abstract：:A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). In this study, CPMV-PARVO1 was inactivated by UV tre...

journal_title：Vaccine

authors： Langeveld JP,Brennan FR,Martínez-Torrecuadrada JL,Jones TD,Boshuizen RS,Vela C,Casal JI,Kamstrup S,Dalsgaard K,Meloen RH,Bendig MM,Hamilton WD

更新日期：2001-06-14 00:00:00

abstract：:In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according to NMR, the two Vi standards...

journal_title：Vaccine

authors： Hitri K,Kuttel MM,De Benedetto G,Lockyer K,Gao F,Hansal P,Rudd TR,Beamish E,Rijpkema S,Ravenscroft N,Bolgiano B

更新日期：2019-06-27 00:00:00

abstract：:The membrane proximal region (MPR) of HIV-1 gp41 is a desirable target for development of a vaccine that elicits neutralizing antibodies since the patient-derived monoclonal antibodies, 2F5 and 4E10, bind to the MPR and neutralize primary HIV isolates. The 2F5 and 4E10 antibodies cross-react with lipids and structural...

journal_title：Vaccine

authors： Watson DS,Szoka FC Jr

更新日期：2009-07-23 00:00:00