Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants.

Abstract:

:Insoluble, pure protein particles could be advantageous as single-entity vaccines or as carriers for small peptide epitopes. Dense gas anti-solvent precipitation was employed to produce pure protein particles which were found to be insoluble in water. As particulate and multimerized antigens are more immunogenic and hence more advantageous for vaccination, particles were produced via this method using ovalbumin as a model antigen. The particles produced had a mean diameter of approximately 300nm, and remained as discrete particles at low pH. At neutral pH or in the presence of electrolyte, the particles exhibited predictable flocculation behaviour to produce aggregates 1-5microm in diameter. Immunisation of mice with these flocculates elicited specific ovalbumin antibody production, T-cell proliferation and a cytotoxic T-cell response, all in the absence of adjuvant. Thus, dense gas processing could be used as a generic method to produce pure protein particulate vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

White PJ,Anastasopoulos F,Church JE,Kuo CY,Boyd BJ,Hickey PL,Tu LS,Burns P,Lew AM,Heath WR,Davey GM,Pouton CW

doi

10.1016/j.vaccine.2008.09.087

subject

Has Abstract

pub_date

2008-12-09 00:00:00

pages

6824-31

issue

52

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)01361-3

journal_volume

26

pub_type

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