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Does the HIV-1 manipulate immune network via gp120 immunoglobulin-like domain involving V3 loop?

Abstract：

:According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp120, either soluble or expressed in multiple form on the surface of the infected cell, can influence the immune response in idiotype(Id)-anti-Id fashion. This might be the mechanism by which HIV induces immunological abnormalities and it should be taken into consideration in vaccine production as suggested by the authors previously.

journal_name

Vaccine

journal_title

Vaccine

authors

Metlas R,Veljković V

doi

10.1016/0264-410x(95)98256-a

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

355-9

issue

4

eissn

0264-410X

issn

1873-2518

pii

0264-410X(95)98256-A

journal_volume

13

pub_type

杂志文章

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