Improved haemagglutinin antigen content in H5N1 candidate vaccine viruses with chimeric haemagglutinin molecules.

abstract：:Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus toxin associated with skin and soft-tissue infections (SSTIs) and life-threatening necrotizing pneumonia in humans. Recent reports have demonstrated that neutralizing antibody to PVL is not protective against SSTI recurrence, thus raising a controversy about...

journal_title：Vaccine

authors： Rasigade JP,Sicot N,Laurent F,Lina G,Vandenesch F,Etienne J

更新日期：2011-06-06 00:00:00

abstract：:Viral hepatitis remains a major contributor to the global disease burden. Mass immunisation strategies against hepatitis B have been adopted by more than 90 developing and industrialised countries. Countries with low hepatitis A endemicity are experiencing cyclical outbreaks and an epidemiological shift, with larger n...

journal_title：Vaccine

authors： Lopalco PL,Salleras L,Barbuti S,Germinario C,Bruguera M,Buti M,Domínguez A

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:Ongoing surveillance is critical to assessing pneumococcal conjugate vaccine (PCV) impact over time. However, robust prospective studies are difficult to implement in resource-poor settings. We evaluated retrospective use of routinely collected data to estimate PCV impact in Rwanda. METHODS:We collected dat...

journal_title：Vaccine

authors： Gatera M,Uwimana J,Manzi E,Ngabo F,Nwaigwe F,Gessner BD,Moïsi JC

更新日期：2016-10-17 00:00:00

abstract：:The hemagglutinin/protease (HA/P) seems to be an attractive locus for the insertion of heterologous tags in live cholera vaccine strains. A deltaCTXphi spontaneous mutant derived from a pathogenic strain of O139 Vibrio cholerae was sequentially manipulated to obtain hapA Colon, two colons celA derivatives which were l...

journal_title：Vaccine

authors： Ledón T,Valle E,Valmaseda T,Cedré B,Campos J,Rodríguez BL,Marrero K,García H,García L,Fando R

更新日期：2003-03-07 00:00:00

abstract：:We have shown previously that expression library immunization is viable alternative approach to induce protective immunity against Neisseria meningitidis serogroup B. In this study we report that few rounds of library screening allow identification of protective pools of defined antigens. A previously reported protect...

journal_title：Vaccine

authors： Yero D,Pajón R,Pérez Y,Fariñas M,Cobas K,Diaz D,Solis RL,Acosta A,Brookes C,Taylor S,Gorringe A

更新日期：2007-07-09 00:00:00

abstract：:We tested the hypothesis that removal of viral lipids using diisopropylether can enhance antigenicity of SIVmac251. DIPE delipidation removed cholesterol from SIVmac251 without significant loss of viral protein or RNA. Mice immunized with the same SIV preparation but boosted with delipidated SIVmac251 exhibited signif...

journal_title：Vaccine

authors： Kitabwalla M,Villinger F,Akeefe H,Liao Z,Mayne AE,Gargano L,Conner AP,Maltais JA,Kunas G,Hildreth JE,Ansari AA,Bellotti M

更新日期：2005-09-07 00:00:00

abstract：:In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-...

journal_title：Vaccine

authors： Luhrs KA,Fouts DL,Manning JE

更新日期：2003-06-20 00:00:00

abstract：:The aim of the study was to investigate factors involved in vaccination acceptance among healthcare workers (HCWs) and adverse reactions rates associated with pandemic influenza vaccination. The study was carried out in the major teaching hospital of Sicily from November 2009 to February 2010 on 2267 HCWs. A total of ...

journal_title：Vaccine

authors： Amodio E,Anastasi G,Marsala MG,Torregrossa MV,Romano N,Firenze A

更新日期：2011-02-04 00:00:00

abstract：:We examined the immunogenicity and protective efficacy of a combined DNA vaccine that included six genes encoding immunodominant antigens from Mycobacterium tuberculosis and Brucella abortus. The IL-12 adjuvant system was used for immunization in combination with the combined DNA vaccine (DNA-IL-12(+)). Mice immunized...

journal_title：Vaccine

authors： Yu DH,Li M,Hu XD,Cai H

更新日期：2007-09-17 00:00:00

abstract：:The Ebola virus epidemic in West Africa proved to be the largest in the history of filovirus outbreaks, causing the World Health Organization to declare a public health emergency of international concern in August of 2014. In collaboration with domestic and international partners, the Biomedical Advanced Research and ...

journal_title：Vaccine

authors： Wolfe DN,Zarrabian AG,Disbrow GL,Espeland EM

更新日期：2019-11-15 00:00:00

abstract：:This study expands and updates through 1995 our earlier report on influenza vaccine use in 18 developed countries. Five of the six countries with high levels of vaccine use in 1992 (> or = 130 doses/1000 population) showed little change or slight declines over the subsequent 3 years. The exception was the United State...

journal_title：Vaccine

authors： Fedson DS,Hirota Y,Shin HK,Cambillard PE,Kiely J,Ambrosch F,Hannoun C,Leese J,Sprenger MJ,Hampson AW,Bro-Jørgensen K,Ahlbom AM,Nøkleby H,Valle M,Olafsson O,Salmerón F,Cloetta J,Rebelo de Andrade H,Snacken R,Donatell

更新日期：1997-10-01 00:00:00

abstract：:We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one o...

journal_title：Vaccine

authors： Fu C,Wang M,Liang J,He T,Wang D,Xu J

更新日期：2007-12-17 00:00:00

abstract：:The literature on natural infections with Japanese encephalitis virus in Japan and subclinical:clinical infection rates was summarized. To detect natural infections, conventional serologic methods were used in the past, while nonstructural 1 protein-based methods have been used recently. Annual infection rates in huma...

journal_title：Vaccine

authors： Konishi E

更新日期：2009-11-23 00:00:00

abstract：:Establishing successful vaccine programs for pregnant women would be the quintessence of preventive medicine when you realize the preventive potential for reproductive problems of many of the new and old vaccines. The development of vaccines to prevent maternal, fetal and newborn disease is actually in its infancy. Th...

journal_title：Vaccine

authors： Brent RL

更新日期：2003-07-28 00:00:00

abstract：:The Global Meningococcal Initiative (GMI) is composed of an international group of scientists, clinicians and public health officials with expertise in meningococcal immunology, epidemiology and prevention. The primary goal of the GMI is the promotion of the global prevention of invasive meningococcal disease through ...

journal_title：Vaccine

authors： Harrison LH,Pelton SI,Wilder-Smith A,Holst J,Safadi MA,Vazquez JA,Taha MK,LaForce FM,von Gottberg A,Borrow R,Plotkin SA

更新日期：2011-04-18 00:00:00

abstract：:We have found out that transfection of the RTG-2 cell line with the viral haemorrhagic septicaemia virus (VHSV) glycoprotein G (G(VHSV))-coding plasmid induces an anti-VHSV state, similar to that induced by poly I:C. Taking the advantage of the constitutive expression of toll-like receptor 9 gene (tlr9) in RTG-2 cells...

journal_title：Vaccine

authors： Ortega-Villaizan M,Chico V,Martinez-Lopez A,Falco A,Perez L,Coll JM,Estepa A

更新日期：2011-01-17 00:00:00

abstract：INTRODUCTION:Observational studies of influenza vaccine effectiveness often study persons seeking medical care for acute respiratory infection (ARI). We conducted a pilot study to determine if vaccine effectiveness could be estimated in the general population with a novel rolling cross-sectional survey sampling design ...

journal_title：Vaccine

authors： Donahue JG,Kieke BA,Szilagy PG,Blumkin AK,Hilgemann D,Flanders WD,Shay DK,Meece J,Gallivan S,Treanor J,Belongia EA

更新日期：2014-11-12 00:00:00

abstract：:FHbp is a major serogroup B meningococcal vaccine antigen. Binding of complement Factor H (FH) to FHbp is specific for human and some non-human primate FH. In previous studies, FH binding to FHbp vaccines impaired protective anti-FHbp antibody responses. In this study we investigated anti-FHbp antibody responses to a ...

journal_title：Vaccine

authors： Giuntini S,Beernink PT,Granoff DM

更新日期：2015-12-16 00:00:00

abstract：:A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...

journal_title：Vaccine

authors： Hsieh HV,Stewart B,Hauer P,Haaland P,Campbell R

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:It is known that antineoplastic treatment may induce secondary immunodeficiency, but studies after childhood sarcoma are rare. Since 1998, the Late Effects Surveillance System (LESS) of the German Society for Paediatric Oncology and Haematology (GPOH) prospectively registers late effects in soft tissue-, ost...

journal_title：Vaccine

authors： Paulides M,Stöhr W,Laws HJ,Graf N,Lakomek M,Berthold F,Schmitt K,Niggli F,Jürgens H,Bielack S,Koscielniak E,Klingebiel T,Langer T

更新日期：2011-02-11 00:00:00

abstract：:Dengue is one of the most important mosquito-borne viral disease causing dengue fever and/or dengue shock syndrome/haemorrhagic fever. In some reports, the non-structural protein 1 (NS1) has been identified as a promising antigen for the development of vaccines against dengue virus (DENV). Apparently, it can elicit a ...

journal_title：Vaccine

authors： Costa SM,Freire MS,Alves AM

更新日期：2006-05-22 00:00:00

abstract：:Non-pathogenic lactic acid bacteria (LAB) are attractive as live carriers to deliver protective antigens to the mucosal immune system. Both persisting and non-persisting strains of lactic acid bacteria have been evaluated and seem to work equally well by the systemic and nasal routes of administration. However, it is ...

journal_title：Vaccine

authors： Grangette C,Müller-Alouf H,Geoffroy M,Goudercourt D,Turneer M,Mercenier A

更新日期：2002-09-10 00:00:00

abstract：:Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students atte...

journal_title：Vaccine

authors： Chiara F,Bartolucci GB,Mongillo M,Ferretto L,Nicolli A,Trevisan A

更新日期：2013-03-25 00:00:00

abstract：INTRODUCTION:Frequency and distribution of HPV types in HIV-infected women with and without cervical neoplasia and their determinants have not been widely studied in India. We report and discuss HPV prevalence and type distribution in HIV-infected women. METHODS:HPV genotyping was done using cervical samples from 1109...

journal_title：Vaccine

authors： Joshi S,Babu JM,Jayalakshmi D,Kulkarni V,Divate U,Muwonge R,Gheit T,Tommasino M,Sankaranarayanan R,Pillai MR

更新日期：2014-02-19 00:00:00

abstract：:In 2003-2004, a national measles seroprevalence study was conducted in Italy and data were analysed by using both commercial ELISA cut-off, and by applying a mixture model. Results of the two methods were compared and interpreted in the light of measles incidence, vaccination coverage and previous seroprevalence data....

journal_title：Vaccine

authors： Rota MC,Massari M,Gabutti G,Guido M,De Donno A,Ciofi degli Atti ML

更新日期：2008-08-12 00:00:00

abstract：:Norovirus (NoV) and hepatitis E virus (HEV) are both enterically-transmitted viruses causing gastroenteritis and hepatitis, respectively, in humans. While a vaccine against HEVs recently became available in China, there is no prophylactic or therapeutic approach against NoVs. Both NoV and HEV have surface protrusions ...

journal_title：Vaccine

authors： Wang L,Cao D,Wei C,Meng XJ,Jiang X,Tan M

更新日期：2014-01-16 00:00:00

abstract：:Since 1992, hepatitis B vaccine has been an integrated part of Thailand's expanded programme on immunisation (EPI). Based on the data from five representative provinces, we have evaluated its impact on the countrywide prevalence of HBV infection and carrier rate. The population studied comprised 400-488 healthy and im...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Vimolket T,Sinlaparatsamee S,Chaiear K,Siraprapasiri T,Khwanjaipanich S,Owatanapanich S,Hirsch P,Chunsuttiwat S

更新日期：2000-11-22 00:00:00

abstract：:Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the pneumococcal type 1 pilus declined dramatically, a decline associated with the elimination of vaccine-type (VT) strains. Here we show that between 2004 and 2007, th...

journal_title：Vaccine

authors： Regev-Yochay G,Hanage WP,Trzcinski K,Rifas-Shiman SL,Lee G,Bessolo A,Huang SS,Pelton SI,McAdam AJ,Finkelstein JA,Lipsitch M,Malley R

更新日期：2010-07-05 00:00:00

abstract：:Infectious laryngotracheitis virus (ILTV) is an alphaherpesvirus that causes acute respiratory disease in chickens worldwide. The virus is horizontally transmitted and causes large outbreaks of disease. Recent studies have shown that a glycoprotein G deficient candidate vaccine strain of ILTV (ΔgG ILTV) is safe and pr...

journal_title：Vaccine

authors： Devlin JM,Hartley CA,Gilkerson JR,Coppo MJ,Vaz P,Noormohammadi AH,Wells B,Rubite A,Dhand NK,Browning GF

更新日期：2011-08-05 00:00:00

abstract：BACKGROUND:Better understanding of vaccine reactogenicity is crucial given its potential impact upon vaccine safety and acceptance. Here we report a comparison between conventional and novel (continuous) methods of monitoring temperature and evaluate any association between reactogenicity and the monocyte activation te...

journal_title：Vaccine

authors： Valente Pinto M,Davis K,Andrews N,Goldblatt D,Borrow R,Southern J,Nordgren IK,Vipond C,Plested E,Miller E,Snape MD

更新日期：2020-11-17 00:00:00