DNA vaccine against the non-structural 1 protein (NS1) of dengue 2 virus.

abstract：:Clinical and post-licensure data have demonstrated that AS03-adjuvanted inactivated split virion vaccines, many with reduced antigen content, are effective against influenza infection. The objective of this review is to provide a comprehensive assessment of the safety of trivalent seasonal, monovalent pre-pandemic and...

journal_title：Vaccine

authors： Cohet C,van der Most R,Bauchau V,Bekkat-Berkani R,Doherty TM,Schuind A,Tavares Da Silva F,Rappuoli R,Garçon N,Innis BL

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...

journal_title：Vaccine

authors： Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

更新日期：2014-12-05 00:00:00

abstract：:A newly developed human diploid cell rabies vaccine (Lyssavac-HDC), produced without added serum albumin and with an effort to remove the virus-inactivating beta-propriolactone prior to addition of the gelatin, L-cysteine and potassium phosphate stabilizer, was tested for safety immunogenicity, adverse reactions and e...

journal_title：Vaccine

authors： Wilde H,Glueck R,Khawplod P,Cryz SJ,Tantawichien T,Thipkong P,Chomchey P,Prakongsri S,Benjavongkulchai M,Sumboonanondha A

更新日期：1995-04-01 00:00:00

abstract：:Ten adult volunteers, with low prevaccination levels of serum IgG antibodies against meningococcal antigens (< 1 microg ml(-1)), received three doses of the Norwegian group B meningococcal outer membrane vesicle (OMV) vaccine intramuscularly at weeks 0, 6 and 46. Anti-OMV IgG subclass responses were measured and compa...

journal_title：Vaccine

authors： Naess LM,Aarvak T,Aase A,Oftung F,Høiby EA,Sandin R,Michaelsen TE

更新日期：1999-02-26 00:00:00

abstract：:Surface modified poly-ɛ-caprolactone microspheres as an antigen carrier was explored in a fish model. Outer membrane vesicles of Edwardsiella tarda adsorbed on to surface modified poly-ɛ-caprolactone microspheres with chitosan and alginate induces both innate and adaptive immune responses which persist up to 63 days o...

journal_title：Vaccine

authors： Behera T,Swain P

更新日期：2012-07-27 00:00:00

abstract：:The annual winter outbreak of influenza is one of the major cause of morbidity and mortality among frail elderly people. The aim of the present study was to identify prevalence and predictors of influenza vaccination in a large European population of frail and old people living in community. This was an observational ...

journal_title：Vaccine

authors： Landi F,Onder G,Carpenter I,Garms-Homolova V,Bernabei R

更新日期：2005-06-10 00:00:00

abstract：:Amino acid residues 421-436 constitute a comparatively conserved determinant of gp120 that participates in the binding of host cell CD4 receptors by HIV-1. We compared the immunogenicity of synthetic Cys-gp120 (421-436) conjugated to KLH via the N terminal Cys residue (KLH-I) and gp120 (421-436) extended at its N term...

journal_title：Vaccine

authors： Karle S,Nishiyama Y,Taguchi H,Zhou YX,Luo J,Planque S,Hanson C,Paul S

更新日期：2003-03-07 00:00:00

abstract：:Montanide ISA 720 is an experimental adjuvant, formulated as water-in-oil emulsions, that induces high antibody titers in several animal species. It has been used in human vaccine trials with malaria and HIV vaccines. The heightened response is likely due, in part, to the formation of a depot at the injection site. Ho...

journal_title：Vaccine

authors： Miles AP,McClellan HA,Rausch KM,Zhu D,Whitmore MD,Singh S,Martin LB,Wu Y,Giersing BK,Stowers AW,Long CA,Saul A

更新日期：2005-03-31 00:00:00

abstract：:Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability to generate a measurable immune response in sheep. Animals of setting 1 (groups A-D) were si...

journal_title：Vaccine

authors： Hilke J,Strobel H,Woelke S,Stoeter M,Voigt K,Grimm L,Meilwes J,Punsmann T,Blaha I,Salditt A,Rohn K,Bastian M,Ganter M

更新日期：2019-09-16 00:00:00

abstract：:Host antiviral genes are important regulators of antiviral immunity and plausible genetic determinants of immune response heterogeneity after vaccination. We genotyped and analyzed 307 common candidate tagSNPs from 12 antiviral genes in a cohort of 745 schoolchildren immunized with two doses of measles-mumps-rubella (...

journal_title：Vaccine

authors： Haralambieva IH,Ovsyannikova IG,Umlauf BJ,Vierkant RA,Shane Pankratz V,Jacobson RM,Poland GA

更新日期：2011-11-08 00:00:00

abstract：:Development of active targeted immunotherapeutics is a rapid developing field in the arena of chronic infectious diseases. The question of repeated, closely spaced administration of immunotherapeutics to achieve a rapid impact on the replicating agent is an important one. We analyzed here, using a prototype adenovirus...

journal_title：Vaccine

authors： Boukhebza H,Dubois C,Koerper V,Evlachev A,Schlesinger Y,Menguy T,Silvestre N,Riedl P,Inchauspé G,Martin P

更新日期：2014-05-30 00:00:00

abstract：:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...

journal_title：Vaccine

authors： Tijhaar EJ,Zheng-Xin Y,Karlas JA,Meyer TF,Stukart MJ,Osterhaus AD,Mooi FR

更新日期：1994-08-01 00:00:00

abstract：:Genetic immunization holds promise as a vaccination method, but has so far proven ineffective in large primate and human trials. Herein, we examined the relative merits of genetic immunization and peptide immunization using bacteriophage λ. Bacteriophage λ has proven effective in immune challenge models using both imm...

journal_title：Vaccine

authors： Thomas BS,Nishikawa S,Ito K,Chopra P,Sharma N,Evans DH,Tyrrell DL,Bathe OF,Rancourt DE

更新日期：2012-02-01 00:00:00

abstract：:Eggs are a major source of human infections with Salmonella. Therefore controlling egg contamination in laying hen flocks is one of the main targets for control programmes. A study was carried out to assess the effect of oral vaccination with TAD Salmonella vac E, TAD Salmonella vac T and with both vaccines TAD Salmon...

journal_title：Vaccine

authors： Gantois I,Ducatelle R,Timbermont L,Boyen F,Bohez L,Haesebrouck F,Pasmans F,van Immerseel F

更新日期：2006-09-11 00:00:00

abstract：:A strategy to improve the immunogenicity of candidate vaccines is to trigger the innate immune system. Triggering of CD40 at the surface of dendritic cells (DC) is essential in the induction of an efficient immune response. Although CD40 agonist antibodies have been shown to be potent inducers of immune responses in e...

journal_title：Vaccine

authors： Miconnet I,Pantaleo G

更新日期：2008-07-29 00:00:00

abstract：:Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no ...

journal_title：Vaccine

authors： Norton PM,Wells JM,Brown HW,Macpherson AM,Le Page RW

更新日期：1997-04-01 00:00:00

abstract：:The feasibility of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine was assessed and a comparison made of immunogenicity and reactogenicity to DTPa and HBV vaccines mixed in one syringe and to concomitant but separate injections as a primary vaccination course in three groups of infants...

journal_title：Vaccine

authors： Usonis V,Bakasenas V,Willems P,Clemens R

更新日期：1997-10-01 00:00:00

abstract：:Experiments were carried out to examine the initial feasibility of immunizing infants and children with inactivated influenza virus vaccine combined with diphtheria-tetanus-pertussis (DTP) vaccine. Groups of mice were immunized with saline vaccine or vaccine mixed with DTP: three doses of vaccine were given 3 weeks ap...

journal_title：Vaccine

authors： Potter CW,Tamizifar H,Jennings R

更新日期：1995-02-01 00:00:00

abstract：:Neutralizing antibody is associated with the prevention and clearance of influenza virus infection. Microneutralization (MN) and hemagglutination inhibition (HI) assays are currently used to evaluate neutralizing antibody responses against human and avian influenza viruses, including H5N1. The MN assay is somewhat lab...

journal_title：Vaccine

authors： Tsai C,Caillet C,Hu H,Zhou F,Ding H,Zhang G,Zhou B,Wang S,Lu S,Buchy P,Deubel V,Vogel FR,Zhou P

更新日期：2009-11-12 00:00:00

abstract：:Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus st...

journal_title：Vaccine

authors： Tamura S

更新日期：2010-08-31 00:00:00

abstract：:Cellular as well as humoral immune reactivity were studied in healthy young (< 30 years; n = 12) and older (> 65 years; n = 12) individuals before as well as 1 month after immunization with a trivalent whole virus influenza vaccine. Before vaccination, peripheral blood mononuclear cell proliferation in response to in ...

journal_title：Vaccine

authors： Saurwein-Teissl M,Steger MM,Glück R,Cryz S,Grubeck-Loebenstein B

更新日期：1998-01-01 00:00:00

abstract：:Conventional influenza vaccines are hampered by slow and limited production capabilities, whereas DNA vaccines can be rapidly produced for global coverage in the event of an emerging pandemic. However, a drawback of DNA vaccines is their generally low immunogenicity in non-human primates and humans. We have previously...

journal_title：Vaccine

authors： Mooij P,Grødeland G,Koopman G,Andersen TK,Mortier D,Nieuwenhuis IG,Verschoor EJ,Fagrouch Z,Bogers WM,Bogen B

更新日期：2019-02-04 00:00:00

abstract：BACKGROUND:Several concepts are available to explain vaccine decision making by individual and inter-individual factors, including risk perception, social conformism and altruism. However, only a few studies have quantified the weight of these determinants in vaccine acceptance. Using a conjoint analysis tool, we aimed...

journal_title：Vaccine

authors： Seanehia J,Treibich C,Holmberg C,Müller-Nordhorn J,Casin V,Raude J,Mueller JE

更新日期：2017-05-09 00:00:00

abstract：:We investigated whether a combined DNA vaccine delivered together with the IL-15 gene (DNA-IL-15(+)) enhanced the immune response against Brucella abortus in mice. Mice vaccinated with DNA-IL-15(+) developed a robust humoral response; Brucella-specific antibodies exhibited a dominance of immunoglobulin G2a (IgG2a) ove...

journal_title：Vaccine

authors： Hu XD,Chen ST,Li JY,Yu DH,Yi-Zhang,Cai H

更新日期：2010-03-11 00:00:00

abstract：:Leptospirosis is an important zoonotic disease worldwide. Subunit vaccines are an attractive intervention strategy against this disease, but potent, non-toxic adjuvants are necessary components to any effective vaccine. Among various adjuvant candidates, liposomes have garnered recent attention for their capacity as c...

journal_title：Vaccine

authors： Faisal SM,Yan W,McDonough SP,Mohammed HO,Divers TJ,Chang YF

更新日期：2009-10-19 00:00:00

abstract：:Amid provider reports of financial barriers as an impediment to adult immunization, this study explores the time and costs of vaccination in adult provider practices. Both a Vaccination Time-Motion Study and Vaccine Practice Management Survey were conducted (March - October 2017) in a convenience sample of 19 family m...

journal_title：Vaccine

authors： Shen A,Khavjou O,King G,Bates L,Zhou F,Leidner AJ,Yarnoff B

更新日期：2019-02-04 00:00:00

abstract：:Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry indus...

journal_title：Vaccine

authors： Li Q,Ren J,Xian H,Yin C,Yuan Y,Li Y,Ji R,Chu C,Qiao Z,Jiao X

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Vaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with increased serum IgE levels. We hypothesized that the vaccination modifies ...

journal_title：Vaccine

authors： Janjanam VD,Mukherjee N,Lockett GA,Rezwan FI,Kurukulaaratchy R,Mitchell F,Zhang H,Arshad H,Holloway JW,Karmaus W

更新日期：2016-12-12 00:00:00

abstract：:This work describes the formulation design and development of a novel protein based adjuvant, a double mutant of heat labile toxin (dmLT), based on knowledge of the protein's structural integrity and physicochemical degradation pathways. Various classes of pharmaceutical excipients were screened for their stabilizing ...

journal_title：Vaccine

authors： Toprani VM,Sahni N,Hickey JM,Robertson GA,Middaugh CR,Joshi SB,Volkin DB

更新日期：2017-10-04 00:00:00

abstract：:Randomized controlled clinical trials represent the best way to establish the therapeutic or preventive value of medicines. This decade has seen a strong shift in the location of clinical trials from industrialized countries to developing countries, including many in Africa. However, without independent strong regulat...

journal_title：Vaccine

authors： Maïga D,Akanmori BD,Chocarro L

更新日期：2009-12-09 00:00:00