Enhancement of cell mediated immune responses using lipid depleted lentivirus as immunogen: a novel approach for inducing recognition of new viral epitopes.

abstract：:Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is p...

journal_title：Vaccine

authors： Comstedt P,Hanner M,Schüler W,Meinke A,Schlegl R,Lundberg U

更新日期：2015-11-04 00:00:00

abstract：:A WHO workshop organized following the 2009 H1N1 pandemic recommended development of alternative influenza vaccine potency assays as high priority that could expedite the release of vaccine lots in the face of future influenza pandemics. We have developed an antibody independent, simple, high throughput receptor-bindi...

journal_title：Vaccine

authors： Khurana S,King LR,Manischewitz J,Coyle EM,Golding H

更新日期：2014-04-17 00:00:00

abstract：:The highly pathogenic avian H5N1 influenza virus has the potential to incite a global pandemic. Therefore, there is an urgent need to develop effective vaccines against these viruses. Because it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to develop vaccines that will co...

journal_title：Vaccine

authors： Ichinohe T,Ainai A,Tashiro M,Sata T,Hasegawa H

更新日期：2009-10-23 00:00:00

abstract：:Scorpions and other venomous animals contain concentrates of biologically active substances developed to block vital physiological and biochemical functions of the victims. These have contrasting human health concerns, provide important pharmacological raw material and pose a serious threat to human life and health in...

journal_title：Vaccine

authors： Gazarian KG,Gazarian T,Hernández R,Possani LD

更新日期：2005-05-16 00:00:00

abstract：:Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we ...

journal_title：Vaccine

authors： Lu YJ,Leite L,Gonçalves VM,Dias Wde O,Liberman C,Fratelli F,Alderson M,Tate A,Maisonneuve JF,Robertson G,Graca R,Sayeed S,Thompson CM,Anderson P,Malley R

更新日期：2010-11-03 00:00:00

abstract：:Six peptides, A, B1, B, C, D and E derived from the primary sequence of Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH) were selected based on lowest homology to human G3PDH and used for immunization of BALB/c mice. Peptides B1 and D induced immunoglobulin (Ig) G1, IgG2a and IgG2b antibodies that...

journal_title：Vaccine

authors： Tallima H,Montash M,Veprek P,Velek J,Jezek J,El Ridi R

更新日期：2003-07-04 00:00:00

abstract：:Routine administration of the quadrivalent human papillomavirus (HPV) vaccine has been recommended for 11-12-year-old males since 2011, but coverage remains low. In a U.S. national sample of parents of 11-17-year-old males (n=779), 78.6% of parents reported their sons had not received the HPV vaccine. The most common ...

journal_title：Vaccine

authors： Donahue KL,Stupiansky NW,Alexander AB,Zimet GD

更新日期：2014-06-30 00:00:00

abstract：:Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6; a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and ...

journal_title：Vaccine

authors： Saito S,Aosai F,Rikihisa N,Mun HS,Norose K,Chen M,Kuroki T,Asano T,Ochiai T,Hata H,Ichinose M,Yano A

更新日期：2001-02-28 00:00:00

abstract：BACKGROUND:Zika virus vaccine development is underway. We examined interest in receiving a Zika virus vaccine (after one becomes commercially available) among students at a large public university in Northern Virginia. METHODS:An online survey of Zika virus-related knowledge, attitudes, and interest in receiving a Zik...

journal_title：Vaccine

authors： Painter JE,Plaster AN,Tjersland DH,Jacobsen KH

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:In 2013, pertussis immunization (Tdap) for pregnant women was implemented in Colombia to protect newborns in response to increased pertussis incidence. OBJECTIVE:To assess the effect of Tdap maternal immunization on the concentration of mother/umbilical cord antibodies and the occurrence of pertussis in inf...

journal_title：Vaccine

authors： Hincapié-Palacio D,Hoyos MC,Ochoa J,Montoya N,García D,Osorio E,Pertussis Working Group.

更新日期：2018-06-22 00:00:00

abstract：:A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the im...

journal_title：Vaccine

authors： Findlow H,Tapia MD,Sow SO,Haidara FC,Coulibaly F,Keita AM,Diallo F,Doumbia M,Traore A,Schluterman N,Clark DA,Borrow R,Levine MM

更新日期：2019-04-24 00:00:00

abstract：:Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the developm...

journal_title：Vaccine

authors： Julkunen I,Melén K,Nyqvist M,Pirhonen J,Sareneva T,Matikainen S

更新日期：2000-12-08 00:00:00

abstract：:After massive epidemics of bluetongue disease in 2006 and 2007, Germany has started a compulsory vaccination program against bluetongue virus serotype 8 (BTV-8). Since the available vaccines had not yet been registered and only limited data were available on their performance, a safety study was conducted with three d...

journal_title：Vaccine

authors： Gethmann J,Hüttner K,Heyne H,Probst C,Ziller M,Beer M,Hoffmann B,Mettenleiter TC,Conraths FJ

更新日期：2009-06-24 00:00:00

abstract：:Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been ...

journal_title：Vaccine

authors： Gayen M,Gupta P,Morazzani EM,Gaidamakova EK,Knollmann-Ritschel B,Daly MJ,Glass PJ,Maheshwari RK

更新日期：2017-06-22 00:00:00

abstract：OBJECTIVES:To determine the proportion of children whose parents prefer them to receive live, attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV), examine reasons for preferences, and determine what percentage of vaccinated children receive other than the preferred type of vaccine and why. METHO...

journal_title：Vaccine

authors： Santibanez TA,Kahn KE,Bridges CB

更新日期：2018-11-19 00:00:00

abstract：:The influenza immunization program in North America has been primarily designed to provide direct benefit to vaccinated individuals at highest risk of serious influenza outcomes. Some evidence suggests that immunization of certain age groups may also extend indirect protective benefit to vulnerable populations. Our go...

journal_title：Vaccine

authors： Sebastian R,Skowronski DM,Chong M,Dhaliwal J,Brownstein JS

更新日期：2008-03-04 00:00:00

abstract：:Transmission-blocking vaccines against malaria parasites target molecules expressed by sexual stage parasites to elicit antibodies that prevent the infection of the mosquito vector. Pvs25 and Pvs28, expressed on the surface of ookinetes, are potential candidates for such a vaccine and induce antibodies that block the ...

journal_title：Vaccine

authors： Hisaeda H,Collins WE,Saul A,Stowers AW

更新日期：2001-12-12 00:00:00

abstract：:Influenza H3N2 viruses have recently drifted from A/Wisconsin/67/05-like to A/Brisbane/10/07-like viruses. The effect of key amino acid substitutions in the hemagglutinin (HA) protein on the replication, antigenicity and immunogenicity of cold-adapted, live attenuated vaccine strains was examined. A/Brisbane/10/07 egg...

journal_title：Vaccine

authors： Chen Z,Zhou H,Jin H

更新日期：2010-05-28 00:00:00

abstract：:A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human vo...

journal_title：Vaccine

authors： Esparza J,Osmanov S,Pattou-Markovic C,Touré C,Chang ML,Nixon S

更新日期：2002-05-06 00:00:00

abstract：BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...

journal_title：Vaccine

authors： Izikson R,Leffell DJ,Bock SA,Patriarca PA,Post P,Dunkle LM,Cox MM

更新日期：2015-11-27 00:00:00

abstract：BACKGROUND:Household-based caregivers serve an important role in protecting the health of cancer patients, who may be vulnerable to infectious diseases due to their cancer treatments. Caregiver preventive care should be prioritized to maintain continuity of care and to reduce potential for transmission of infectious di...

journal_title：Vaccine

authors： Marellapudi A,King AR,Bednarczyk RA

更新日期：2020-09-11 00:00:00

abstract：:To evaluate the utility of plasmid DNA vaccination against disease caused by herpes simplex virus (HSV), we compared the strength of protection against lethal challenge following natural virus infection with that following vaccination with a plasmid encoding HSV glycoprotein gD (gD-DNA). We further determined the cell...

journal_title：Vaccine

authors： Nass PH,Elkins KL,Weir JP

更新日期：2001-01-08 00:00:00

abstract：:Measles vaccination was performed in the arctic district of Scoresbysund, Greenland in 1968, which had never been exposed to natural measles. More than 90% of the total population was vaccinated and a 94-100% seroconversion was obtained. During a serological survey to examine the immunity status of the vaccinees, it w...

journal_title：Vaccine

authors： Pedersen IR,Mordhorst CH,Glikmann G,von Magnus H

更新日期：1989-08-01 00:00:00

abstract：:Immunogenicity of inactivated virus or subviral vaccines may be enhanced by complexing with an IgG antibody. Such antibody would increase the uptake, processing and presentation of the vaccine's antigens by antigen presenting cells (APC), via the adhesion of the antibody-vaccine complex to Fc-receptors on macrophages ...

journal_title：Vaccine

authors： Galili U,Repik PM,Anaraki F,Mozdzanowska K,Washko G,Gerhard W

更新日期：1996-03-01 00:00:00

abstract：:Since 2004, general varicella vaccination has been recommended for all children 11-14 months of age in Germany. The objective of this study was to examine vaccination coverage in children and factors associated with parental acceptance during the first years after recommendation. In a regional surveillance area, cross...

journal_title：Vaccine

authors： Streng A,Seeger K,Grote V,Liese JG

更新日期：2010-08-09 00:00:00

abstract：:Currently, infections of hand, foot and mouth disease (HFMD) due to Human Enterovirus 71 (EV71) cannot be prevented or treated, as there are no suitable vaccines or antiviral drugs. This study aimed to identify potential vaccine candidates for EV71 using in silico analysis of its viral capsid proteins. A combined in s...

journal_title：Vaccine

authors： Kirk K,Poh CL,Fecondo J,Pourianfar H,Shaw J,Grollo L

更新日期：2012-11-19 00:00:00

abstract：:A booster dose of a formalin-inactivated, cell culture-propagated Rift Valley fever vaccine (TSI-GSD-200) was administered without significant reactogenicity to 60 volunteers 18 months after they received a three dose primary series. Blood was drawn for serological testing prior to boosting and 10, 49, and 180 days th...

journal_title：Vaccine

authors： Kark JD,Aynor Y,Peters CJ

更新日期：1985-06-01 00:00:00

abstract：:Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches ...

journal_title：Vaccine

authors： Reed DS,Mohamadzadeh M

更新日期：2007-03-01 00:00:00

abstract：:Nearly half of the proteins in the complement system serve in regulation. Control at the central step of C3 activation is provided by an orchestrated interplay of membrane and plasma regulators. A model system employing Chinese hamster ovary (CHO) cells transfected with human regulators was employed to assist in makin...

journal_title：Vaccine

authors： Liszewski MK,Fang CJ,Atkinson JP

更新日期：2008-12-30 00:00:00

abstract：:Foetal Bovine Serum (FBS) and porcine trypsin are one of the essential raw materials used in the manufacturing of cell culture based viral vaccines. Being from animal origin, these raw materials can potentially contaminate the final product by known or unknown adventitious agents. The issue is more serious in case of ...

journal_title：Vaccine

authors： Vaidya V,Dhere R,Agnihotri S,Muley R,Patil S,Pawar A

更新日期：2018-07-05 00:00:00