Abstract：
:A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the immunogenicity of MCV, which was used as a comparator vaccine to TIV, in this population. Third-trimester pregnant Malian women were randomized to receive TIV or MCV. Blood samples were collected from women prior to vaccination, 28 days post-vaccination, at delivery and 3 and 6 months post-delivery and from infants at birth and 3 and 6 months of age. Meningococcal-specific serogroup (Men) A, C, Y and W-specific antibodies were measured by enzyme linked immunosorbent assay in a randomly selected subset of 50 mother-infant pairs where the mother had received MCV. At birth, 94.0% (47/50) of infants had MenA specific IgG levels ≥ 2 µg/mL decreasing to 72.9% and 30.4% at 3 and 6 months of age. For MenC, 81.3% (39/48) of infants had MenC specific IgG levels ≥ 2 µg/mL at birth decreasing to 29.4% and 17.8% at 3 and 6 months of age. For MenY, 89.6% (43/48) of infants had MenY specific IgG levels ≥ 2 µg/mL at birth decreasing to 64.6% and 62.5% at 3 and 6 months of age. For MenW, 89.6% (43/48) of infants had MenW specific IgG levels ≥ 2 μg/ml at birth decreasing to 62.5% and 41.7% at 3 and 6 months of age. Maternal immunization with MCV conveyed protective levels of IgG at birth through to 3 months of age in the majority of infants.
journal_name
Vaccinejournal_title
Vaccineauthors
Findlow H,Tapia MD,Sow SO,Haidara FC,Coulibaly F,Keita AM,Diallo F,Doumbia M,Traore A,Schluterman N,Clark DA,Borrow R,Levine MMdoi
10.1016/j.vaccine.2019.03.045subject
Has Abstractpub_date
2019-04-24 00:00:00pages
2477-2481issue
18eissn
0264-410Xissn
1873-2518pii
S0264-410X(19)30379-2journal_volume
37pub_type
杂志文章,随机对照试验相关文献
VACCINE文献大全abstract：:The global health community is beginning to gain an understanding of the global burden of norovirus-associated disease, which appears to have significant burden in both developed- and developing-country populations. Of particular importance is the growing recognition of norovirus as a leading cause of gastroenteritis ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2016.03.077
更新日期：2016-06-03 00:00:00
abstract：:Currently, commercial porcine rotavirus vaccines remain varied limitations. The objective of this study is to develop an alternative porcine rotavirus subunit vaccine candidate by parenteral administration, which enables to elicit robust immune responses against most prevalence porcine rotavirus strains. The bacterial...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.07.011
更新日期：2015-08-26 00:00:00
abstract：:Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replicatio...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.10.038
更新日期：2007-02-26 00:00:00
abstract：:We describe here the preclinical development of a dengue vaccine composed of recombinant subunit carboxy-truncated envelope (E) proteins (DEN-80E) for each of the four dengue serotypes. Immunogenicity and protective efficacy studies in Rhesus monkeys were conducted to evaluate monovalent and tetravalent DEN-80E vaccin...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.06.067
更新日期：2015-08-07 00:00:00
abstract：:The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.05.048
更新日期：2018-12-18 00:00:00
abstract：:Malaria remains an important health threat to non-immune travelers with the explosive growth of global travel. Populations at high risk of acquiring malaria infections include once semi-immune travelers who visit friends and relatives, military forces, business travelers and international tourists with destinations to...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.10.004
更新日期：2015-12-22 00:00:00
abstract：:Epidemic meningococcal meningitis is an important public health problem in sub-Saharan Africa. Current control measures rely on reactive immunizations with polysaccharide (PS) vaccines that do not induce herd immunity and are of limited effectiveness in those under 2 years of age. Conversely, polysaccharide conjugate ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.04.049
更新日期：2007-09-03 00:00:00
abstract：:Systemic and mucosal immune responses were effectively induced following the subcutaneous administration of Haemophilus influenzae type b oligosaccharide conjugated to diphtheria toxoid vaccine in a formulation containing the active form of vitamin D3. IgA and IgG antibodies with specificity for both the protein and o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00147-4
更新日期：1999-08-06 00:00:00
abstract：:Due to viral strains, influenza season, and consultations and admission rates varying from country to country, the continued economic evaluation of influenza vaccination for the elderly people aged 65 years and above is paramount, particularly in areas with dense population. Efficacy and cost-effective analysis of inf...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.10.011
更新日期：2005-03-14 00:00:00
abstract：:To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 microg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 microg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only lo...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2007.08.042
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Although guidelines for prophylactic human papillomavirus (HPV) vaccination recommend two doses for girls ages 9-14 years, several studies have demonstrated similar protection with one dose. Our objective was to evaluate the long-term health and economic impacts of routine one-dose HPV vaccination compared t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.04.061
更新日期：2018-08-06 00:00:00
abstract：:Despite the availability of anti-microbial agents effective against Neisseria meningitidis, meningococcal disease continues to be a major global health problem, particularly in the very young. Serogroup A meningococci cause large epidemics in sub-Saharan Africa, whilst serogroups B and C organisms are responsible for ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2005.01.051
更新日期：2005-03-18 00:00:00
abstract：:Host antiviral genes are important regulators of antiviral immunity and plausible genetic determinants of immune response heterogeneity after vaccination. We genotyped and analyzed 307 common candidate tagSNPs from 12 antiviral genes in a cohort of 745 schoolchildren immunized with two doses of measles-mumps-rubella (...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.09.043
更新日期：2011-11-08 00:00:00
abstract：:Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly interv...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00442-9
更新日期：2000-03-17 00:00:00
abstract：:Concerns about a potential link between sudden infant death syndrome (SIDS), attention deficit and hyperactivity disorder (ADHD) and vaccination are unsupported by longitudinal evidence. The analyses employed a multivariate mixed-effects model analyzing data from the National Immunization Survey, School Vaccination As...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.12.065
更新日期：2018-01-29 00:00:00
abstract：:One hundred and eight primary school students who had been vaccinated with three doses of a plasma-derived hepatitis B vaccine were randomly divided into two groups, to receive a booster dose of either the same vaccine or of a recombinant yeast-derived vaccine. The pre-booster anti-hepatitis B surface antigen (HBs) ge...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(91)90294-g
更新日期：1991-10-01 00:00:00
abstract：:Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several antigens, in addition to the polysaccharide capsule, have been implicated in both the virulence and protective immunity against Streptococcus pneumoniae; one of ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.020
更新日期：2012-02-01 00:00:00
abstract：:While the large majority of parents in the U.S. vaccinate their children according to the recommended immunization schedule, some parents have refused or delayed vaccinating, often citing safety concerns. In response to public concern, the U.S. Institute of Medicine (IOM) evaluated existing research regarding the safe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.10.082
更新日期：2016-02-15 00:00:00
abstract：UNLABELLED:In low-income countries early measles vaccine (MV) is associated with reduced child mortality which cannot be explained by prevention of measles. A large thymus gland in infancy is also associated with reduced mortality. We hypothesized that early MV is associated with increased thymic size. Within a randomi...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2014.01.034
更新日期：2014-03-26 00:00:00
abstract：:We evaluated immunologic predictors of response to HBV vaccine administered in the presence or absence of GM-CSF in HIV infected individuals. We measured peripheral blood hematopoietic progenitor, monocyte and myeloid-derived suppressor cell (MDSC) frequencies, and expression of GMCSF receptor on monocytes and MDSCs, ...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2011.02.092
更新日期：2011-04-27 00:00:00
abstract：:Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines. Here we used a rabbit model to compare quantitatively and qualitatively the antibody responses induced by poly(D,L-lactide) nanoparticles (PLA) and by emulsion adjuvant MF59 using three HIV-1 antigens: p24ga...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.08.060
更新日期：2007-10-23 00:00:00
abstract：:Age related deterioration in the function of the immune system has been recognised in many species. The clinical presentations of such immune dysfunction are an age-related increased susceptibility to certain infections, and an increased incidence of autoimmune disease and certain cancers. Laboratory investigations re...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(99)00498-3
更新日期：2000-02-25 00:00:00
abstract：:We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.11.077
更新日期：2005-12-01 00:00:00
abstract：:The ability of bioinformatics to characterize genomic sequences from pathogenic bacteria for prediction of genes that may encode vaccine candidates, e.g. surface localized proteins, has been evaluated. By applying appropriate tools for genomic mining to the published sequence of Haemophilus influenzae Rd genome, it wa...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00256-5
更新日期：2000-11-08 00:00:00
abstract：:CD8(+) T-cell responses provide beneficial antiviral immunity against human immunodeficiency virus 1 (HIV-1). In this study, we show that intragastric vaccination with a Salmonella HIV-1 Env DNA vaccine vector generates Env-specific CD8(+) T-cells, both in mucosal and systemic lymphoid tissue. By contrast, intramuscul...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00330-9
更新日期：2001-11-12 00:00:00
abstract：BACKGROUND:Little is known about inactivated influenza vaccine effectiveness (IVE) in preventing very severe disease, including influenza-associated intensive care unit (ICU) admissions. METHODS:The Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) project enrolled adults (age...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.07.028
更新日期：2018-09-18 00:00:00
abstract：:A reverse genetics infectious bursal disease virus (RG-IBDV) that contained authentic 3' RNA sequence was characterized both in vitro and in vivo. LP1-IBDV, a cell line-adapted IBDV strain variant E (VE) was used as the parent virus for constructing viral cDNA clones. Authentic 3' RNA sequence was generated by using c...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.11.040
更新日期：2013-01-11 00:00:00
abstract：:Fertile turkey eggs after 24 days of incubation were vaccinated in ovo with a commercial live attenuated subtype A avian pneumovirus (APV) vaccine. Hatchability was not adversely affected. When a high dose (10 times maximum commercial dose) of vaccine was tested in maternal antibody negative (MA-) eggs, mild clinical ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00689-8
更新日期：2003-03-28 00:00:00
abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.03.049
更新日期：2020-05-08 00:00:00
abstract：:The phrase "Process is the Product" is often applied to biologics, including multicomponent vaccines composed of complex components that evade complete characterization. Vaccine production processes must be defined and locked early in the development cycle to ensure consistent quality of the vaccine throughout scale-u...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.100
更新日期：2018-05-24 00:00:00
