当前位置： SCI文献检索 > VACCINE期刊下所有文献 > The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant.

The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant.

Abstract：

:Systemic and mucosal immune responses were effectively induced following the subcutaneous administration of Haemophilus influenzae type b oligosaccharide conjugated to diphtheria toxoid vaccine in a formulation containing the active form of vitamin D3. IgA and IgG antibodies with specificity for both the protein and oligosaccharide components of the vaccine were detectable in mucosal secretions following immunization. The IgA and IgG mucosal antibodies were produced locally, and were functional as demonstrated by their diphtheria toxin neutralizing activity. Our data suggests that subcutaneous tissues can effectively serve as effective antigen presenting sites for both mucosal and systemic immune responses to antigens administered in combination with vitamin D3.

journal_name

Vaccine

journal_title

Vaccine

authors

Enioutina EY,Visic D,McGee ZA,Daynes RA

doi

10.1016/s0264-410x(99)00147-4

subject

Has Abstract

pub_date

1999-08-06 00:00:00

pages

3050-64

issue

23-24

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(99)00147-4

journal_volume

17

pub_type

杂志文章

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