Abstract：
:Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a bivalent vaccine against Plasmodium falciparum malaria and typhoid fever, which are co-endemic in many parts of the world, by conjugating Vi polysaccharide, an approved antigen in typhoid vaccine, to Pfs25, a malaria transmission blocking vaccine antigen in clinical trials. Vi-Pfs25 conjugates induced strong immune responses against both Vi and Pfs25 in mice, whereas the unconjugated antigens are poorly immunogenic. Functional assays of immune sera revealed potent transmission blocking activity mediated by anti-Pfs25 antibody and serum bactericidal activity due to anti-Vi antibody. Pfs25 conjugation to Vi modified the IgG isotype distribution of antisera, inducing a Th2 polarized immune response against Vi antigen. This conjugate may be further developed as a bivalent vaccine to concurrently target malaria and typhoid fever.
journal_name
Vaccinejournal_title
Vaccineauthors
An SJ,Scaria PV,Chen B,Barnafo E,Muratova O,Anderson C,Lambert L,Chae MH,Yang JS,Duffy PEdoi
10.1016/j.vaccine.2018.04.035subject
Has Abstractpub_date
2018-05-17 00:00:00pages
2978-2984issue
21eissn
0264-410Xissn
1873-2518pii
S0264-410X(18)30518-8journal_volume
36pub_type
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