Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model.

Abstract:

:We investigated the therapeutic effects of romurtide, a synthetic muramyl dipeptide derivative, on experimental thrombocytopenia induced by carboplatin in cynomolgus monkeys. A prolonged thrombocytopenia due to a severe myelosuppression was induced by carboplatin. Romurtide given subcutaneously elevated significantly the peripheral platelet counts during both early initiation and later recovery phase of thrombocytopenia, thereby shortening the time required for recovery to a normal platelet level and the duration of thrombocytopenia. An oral administration of romurtide was also found to have a similar therapeutic efficacy to subcutaneous administration. These results demonstrated a possible therapeutic potential of romurtide in the management of thrombocytopenia associated with myelosuppression.

journal_name

Vaccine

journal_title

Vaccine

authors

Namba K,Nitanai H,Otani T,Azuma I

doi

10.1016/s0264-410x(96)00064-3

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1322-6

issue

14

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(96)00064-3

journal_volume

14

pub_type

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