Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18.


:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naïve and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were approximately 12- to 26-fold higher than those observed in baseline-naïve women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported.






Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,




Has Abstract


2006-07-07 00:00:00
















  • Using pCIN-mIL-4 DNA vector to express mRNA and protein and to improve herpes simplex virus-induced Behcet's disease symptoms in mice.

    abstract::Behcet's disease (BD) is a chronic, recurrent, inflammatory, multisystemic disorder characterized primarily by vasculitis. The etiopathogenesis of BD involves immunogenetics, infectious organisms (streptococcus, herpes simplex virus), immunoregulation and vascular dysfunctions. We previously found that immunoregulatio...


    pub_type: 杂志文章


    authors: Lee SI,Kwon HJ,Lee ES,Yang BC,Bang D,Lee S,Sohn S

    更新日期:2007-10-10 00:00:00

  • Vaccination of sheep with Quil-A® adjuvant expands the antibody repertoire to the Fasciola MF6p/FhHDM-1 antigen and administered together impair the growth and antigen release of flukes.

    abstract::Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1-polarizing adjuvan...


    pub_type: 杂志文章


    authors: Orbegozo-Medina RA,Martínez-Sernández V,González-Warleta M,Castro-Hermida JA,Mezo M,Ubeira FM

    更新日期:2018-04-05 00:00:00

  • Reduction of foot-and-mouth disease (FMD) virus load in nasal excretions, saliva and exhaled air of vaccinated pigs following direct contact challenge.

    abstract::In future, a policy of "vaccinate-to-live" may be included in the repertoire of foot-and-mouth disease (FMD) control measures and in support of this approach, we have investigated the hypothesis that vaccine-induced reduction in virus replication and excretion from pigs can be correlated to the severity of clinical si...


    pub_type: 杂志文章


    authors: Parida S,Fleming L,Oh Y,Mahapatra M,Hamblin P,Gloster J,Doel C,Gubbins S,Paton DJ

    更新日期:2007-11-07 00:00:00

  • A new TB vaccine, MVA85A, induces durable antigen-specific responses 14 months after vaccination in African infants.

    abstract::This study aimed to evaluate the durability of the immunogenicity of MVA85A beyond infancy. Participants in an immunogenicity study of MVA85A administered at age of 4 months had additional evaluation 14 months after initial vaccination for IFN-γ ELISPOT responses to Ag85A peptide and ESAT6/CFP-10 and tuberculin skin t...


    pub_type: 杂志文章,随机对照试验


    authors: Odutola AA,Owolabi OA,Owiafe PK,McShane H,Ota MO

    更新日期:2012-08-17 00:00:00

  • A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response.

    abstract::A strategy to improve the immunogenicity of candidate vaccines is to trigger the innate immune system. Triggering of CD40 at the surface of dendritic cells (DC) is essential in the induction of an efficient immune response. Although CD40 agonist antibodies have been shown to be potent inducers of immune responses in e...


    pub_type: 杂志文章


    authors: Miconnet I,Pantaleo G

    更新日期:2008-07-29 00:00:00

  • Antigenic differences among Newcastle disease virus strains of different genotypes used in vaccine formulation affect viral shedding after a virulent challenge.

    abstract::Strains of Newcastle disease virus (NDV) can be separated into genotypes based on genome differences even though they are antigenically considered to be of a single serotype. It is widely recognized that an efficacious Newcastle disease (ND) vaccine made with any NDV does induce protection against morbidity and mortal...


    pub_type: 杂志文章


    authors: Miller PJ,King DJ,Afonso CL,Suarez DL

    更新日期:2007-10-10 00:00:00

  • Prevalence of human papillomavirus types in cervical and oral cancers in central India.

    abstract::Cervical cancer that is associated with high-risk human papillomaviruses (HPV) is the most common malignancy in Indian women. Therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. However, relatively little is known about the prevalence of the different H...


    pub_type: 杂志文章


    authors: Gheit T,Vaccarella S,Schmitt M,Pawlita M,Franceschi S,Sankaranarayanan R,Sylla BS,Tommasino M,Gangane N

    更新日期:2009-01-29 00:00:00

  • Changes in prevalence of influenza vaccination and strength of association of factors predicting influenza vaccination over time--results of two population-based surveys.

    abstract::Two cross-sectional population-based telephone surveys interviewed 877 and 1,103 respondents aged >or=65. When compared to the first survey, respondents of the second survey were more likely to have heard of influenza vaccination (IV) (adjusted OR=4.09), to have received IV (adjusted OR=2.04) or to have done so in the...


    pub_type: 杂志文章


    authors: Lau JT,Kim JH,Choi KC,Tsui HY,Yang X

    更新日期:2007-11-28 00:00:00

  • Candidate peptide vaccine induced protection against classical swine fever virus.

    abstract::Former investigations demonstrated that the envelope glycoprotein E2 could protect pigs from classical swine fever virus (CSFV). Based on these findings, we prepared synthetic peptide vaccine using E2 N-terminal antigenic units B/C and hoped to induce protective activity against lethal challenge of virulent CSFV strai...


    pub_type: 杂志文章


    authors: Dong XN,Wei K,Liu ZQ,Chen YH

    更新日期:2002-12-13 00:00:00

  • Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection.

    abstract::Clinical trials with pandemic influenza vaccine candidates have focused on aluminium hydroxide as an adjuvant to boost humoral immune responses. In this study we investigated the effect of aluminium hydroxide on the magnitude and type of immune response induced by whole-inactivated virus (WIV) vaccine. Balb/c mice wer...


    pub_type: 杂志文章


    authors: Bungener L,Geeraedts F,Ter Veer W,Medema J,Wilschut J,Huckriede A

    更新日期:2008-05-02 00:00:00

  • Persistence of anti-HBs in children vaccinated against viral hepatitis B in the first year of life: follow-up at 5 and 10 years.

    abstract::The persistence of anti-HBs protective levels in groups of children who had been immunized against Hepatitis B 5 and 10 years earlier, in their first year of life, has been studied. The results were analyzed according to the type of vaccine (both plasma-derived and DNA recombinant) and the number of doses administered...


    pub_type: 杂志文章


    authors: Da Villa G,Peluso F,Picciotto L,Bencivenga M,Elia S,Pelliccia MG

    更新日期:1996-11-01 00:00:00

  • Regulation of CD4 T cell memory by OX40 (CD134).

    abstract::CD4 memory T cells play a critical role in protection against repeated exposure to infectious agents such as viruses, bacteria, and helminth parasites, yet can also contribute to the aberrant immune responses associated with autoimmune and allergic reactions. Understanding the mechanisms that control effective memory ...


    pub_type: 杂志文章,评审


    authors: Salek-Ardakani S,Croft M

    更新日期:2006-02-13 00:00:00

  • Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers.

    abstract:OBJECTIVE:Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. DESIGN:German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux) in an open-label study. Blood samples were taken before (n=261...


    pub_type: 临床试验,杂志文章


    authors: Littmann M,Hülsse C,Riffelmann M,Wirsing von König CH

    更新日期:2008-05-02 00:00:00

  • A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle.

    abstract::Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seas...


    pub_type: 杂志文章,随机对照试验


    authors: Lankester F,Russell GC,Lugelo A,Ndabigaye A,Mnyambwa N,Keyyu J,Kazwala R,Grant D,Percival A,Deane D,Haig DM,Cleaveland S

    更新日期:2016-02-03 00:00:00

  • Knowledge, attitudes and beliefs related to seasonal influenza vaccine among pregnant women in Thailand.

    abstract:BACKGROUND:In 2009, Thailand recommended pregnant women be prioritized for influenza vaccination. Vaccine uptake among Thai pregnant women is lower than other high-risk groups. METHODS:During December 2012-April 2013, we conducted a cross-sectional survey of a convenience sample of Thai pregnant women aged ≥ 15 years ...


    pub_type: 杂志文章


    authors: Ditsungnoen D,Greenbaum A,Praphasiri P,Dawood FS,Thompson MG,Yoocharoen P,Lindblade KA,Olsen SJ,Muangchana C

    更新日期:2016-04-19 00:00:00

  • Immunization with an engineered mutant trans-sialidase highly protects mice from experimental Trypanosoma cruzi infection: a vaccine candidate.

    abstract::Chagas' disease is a major tropical disease for which a cure for chronic phase does not exist yet. Trypanosoma cruzi trans-sialidase (TS) seems to be involved in relevant processes such as infectivity, host survival and, very importantly, disease pathogenesis. In this study, we show that mice vaccinated with an engine...


    pub_type: 杂志文章


    authors: Fontanella GH,De Vusser K,Laroy W,Daurelio L,Nocito AL,Revelli S,Contreras R

    更新日期:2008-05-02 00:00:00

  • Impact of the introduction of rotavirus vaccine on the timeliness of other scheduled vaccines: the Australian experience.

    abstract::Strict age limits for receipt of rotavirus vaccines and simultaneous use of vaccines requiring two (Rotarix(®)) and three (RotaTeq(®)) doses in Australia may impact on coverage and timeliness of other vaccines in the infant schedule. Using data from the Australian Childhood Immunisation Register (ACIR), coverage and t...


    pub_type: 杂志文章


    authors: Hull BP,Menzies R,Macartney K,McIntyre PB

    更新日期:2013-04-08 00:00:00

  • Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits.

    abstract::Varied doses of Taishan Pinus massoniana pollen polysaccharide (TPPPS) and Astragalus polysaccharide (APS) extracted by hot water extraction and ethanol precipitation method were added to the vaccine in order to prepare polysaccharide-rabbit haemorrhagic disease (RHD) tissue inactivated vaccine. The purpose was to stu...


    pub_type: 杂志文章


    authors: Wei K,Sun Z,Yan Z,Tan Y,Wang H,Zhu X,Wang X,Sheng P,Zhu R

    更新日期:2011-03-21 00:00:00

  • Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection.

    abstract:BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...


    pub_type: 杂志文章,随机对照试验


    authors: Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

    更新日期:2014-12-05 00:00:00

  • Advancing a vaccine to prevent hookworm disease and anemia.

    abstract::A human hookworm vaccine is under development and in clinical trials in Africa and the Americas. The vaccine contains the Na-APR-1 and Na-GST-1 antigens. It elicits neutralizing antibodies that interfere with establishment of the adult hookworm in the gut and the ability of the parasite to feed on blood. The vaccine t...


    pub_type: 杂志文章


    authors: Hotez PJ,Beaumier CM,Gillespie PM,Strych U,Hayward T,Bottazzi ME

    更新日期:2016-06-03 00:00:00

  • Expression of HIV-1 envelope gene by recombinant avipox viruses.

    abstract::Recombinant canarypox (CP) and fowlpox (FP) viruses that contained two forms of the HIV-1 (SF2 strain) env gene were engineered and their expression analysed in chick, simian and human cells. These vectors can efficiently replicate in avian but not in mammalian cells, in which infection is abortive. The two forms, con...


    pub_type: 杂志文章


    authors: Radaelli A,De Giuli Morghen C

    更新日期:1994-09-01 00:00:00

  • Vaxvec: The first web-based recombinant vaccine vector database and its data analysis.

    abstract::A recombinant vector vaccine uses an attenuated virus, bacterium, or parasite as the carrier to express a heterologous antigen(s). Many recombinant vaccine vectors and related vaccines have been developed and extensively investigated. To compare and better understand recombinant vectors and vaccines, we have generated...


    pub_type: 杂志文章


    authors: Deng S,Martin C,Patil R,Zhu F,Zhao B,Xiang Z,He Y

    更新日期:2015-11-27 00:00:00

  • Hepatitis B vaccination at three months of age: a successful strategy?

    abstract::Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students atte...


    pub_type: 杂志文章


    authors: Chiara F,Bartolucci GB,Mongillo M,Ferretto L,Nicolli A,Trevisan A

    更新日期:2013-03-25 00:00:00

  • Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...


    pub_type: 杂志文章


    authors: Amani J,Salmanian AH,Rafati S,Mousavi SL

    更新日期:2010-10-04 00:00:00

  • Immunogenicity and safety of a new live attenuated herpes zoster vaccine (NBP608) compared to Zostavax® in healthy adults aged 50 years and older.

    abstract::A multi-centre, randomised, double-blinded, active-controlled, parallel-group clinical trial was carried out to assess the immunogenicity and safety of NBP608-a newly developed live-attenuated zoster vaccine in Korea-relative to Zostavax® in healthy adults aged 50 years or older. Immune responses to the vaccine were e...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Choi WS,Choi JH,Jung DS,Choi HJ,Kim YS,Lee J,Jang HC,Shin EC,Park JS,Kim H,Cheong HJ

    更新日期:2019-06-12 00:00:00

  • Points to consider in the development of a surrogate for efficacy of novel Japanese encephalitis virus vaccines.

    abstract::Although an effective killed virus vaccine to prevent illness due to Japanese encephalitis virus (JEV) infection exists, many authorities recognize that a safe, effective live JEV vaccine is desirable in order to reduce the cost and the number of doses of vaccine required per immunization. A large-scale clinical effic...


    pub_type: 杂志文章,评审


    authors: Markoff L

    更新日期:2000-05-26 00:00:00

  • Vaccine hesitancy towards childhood immunisation amongst urban pregnant mothers in Malaysia.

    abstract:BACKGROUND:Vaccine hesitancy is a complex behaviour which involves various degrees of indecision about specific vaccines or vaccination uptake. Access to antenatal care had been associated with positive vaccine behavior. OBJECTIVE:To determine the prevalence of vaccine hesitancy towards childhood immunisation amongst ...


    pub_type: 杂志文章


    authors: Kalok A,Loh SYE,Chew KT,Abdul Aziz NH,Shah SA,Ahmad S,Mohamed Ismail NA,Abdullah Mahdy Z

    更新日期:2020-02-24 00:00:00

  • Salmonella Enteritidis ghost vaccine carrying the hemagglutinin globular head (HA1) domain from H1N1 virus protects against salmonellosis and influenza in chickens.

    abstract::This study evaluated the attenuated Salmonella Enteritidis (SE) ghost strain JOL2114 (Δlon ΔcpxR Δasd), which displays on the bacterial surface the H1N1 hemagglutinin globular head portion (HA1; amino acid residues 63-286) on the bacterial surface for protective efficacy against Salmonella and H1N1 challenge in the ch...


    pub_type: 杂志文章


    authors: Won G,Senevirathne A,Lee JH

    更新日期:2020-06-09 00:00:00

  • Evaluation of single-round infectious, chimeric dengue type 1 virus as an antigen for dengue functional antibody assays.

    abstract::Dengue fever and dengue hemorrhagic fever are endemic throughout tropical and subtropical countries. Four serotypes of dengue viruses (DENV-1 to DENV-4), each with several genotypes including various subclades, are co-distributed in most endemic areas. Infection-neutralizing and -enhancing antibodies are believed to p...


    pub_type: 杂志文章


    authors: Yamanaka A,Suzuki R,Konishi E

    更新日期:2014-07-23 00:00:00

  • Molecular characterisation of pneumococcal serotype 16F: Established predominant carriage and otitis media serotype in the 7vPCV era.

    abstract::Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneum...


    pub_type: 杂志文章


    authors: Marsh RL,Smith-Vaughan H,Beissbarth J,Hare K,Kennedy M,Wigger C,Mellon G,Stubbs E,Gadil JR,Pettit A,Mackenzie G,Tipakalippa P,Morris PS,Leach AJ

    更新日期:2007-03-22 00:00:00