Abstract：
:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naïve and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were approximately 12- to 26-fold higher than those observed in baseline-naïve women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported.
journal_name
Vaccinejournal_title
Vaccineauthors
Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,doi
10.1016/j.vaccine.2006.04.068subject
Has Abstractpub_date
2006-07-07 00:00:00pages
5571-83issue
27-28eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)00466-Xjournal_volume
24pub_type
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