Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18.

Abstract:

:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naïve and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were approximately 12- to 26-fold higher than those observed in baseline-naïve women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported.

journal_name

Vaccine

journal_title

Vaccine

authors

Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,

doi

10.1016/j.vaccine.2006.04.068

subject

Has Abstract

pub_date

2006-07-07 00:00:00

pages

5571-83

issue

27-28

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00466-X

journal_volume

24

pub_type

杂志文章,多中心研究,随机对照试验

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