Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18.


:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naïve and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were approximately 12- to 26-fold higher than those observed in baseline-naïve women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported.






Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,




Has Abstract


2006-07-07 00:00:00
















  • Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components.

    abstract::We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...


    pub_type: 杂志文章


    authors: Mendelson I,Gat O,Aloni-Grinstein R,Altboum Z,Inbar I,Kronman C,Bar-Haim E,Cohen S,Velan B,Shafferman A

    更新日期:2005-12-01 00:00:00

  • The efficacy of pneumococcal capsular polysaccharide-specific antibodies to serotype 3 Streptococcus pneumoniae requires macrophages.

    abstract::The efficacy of antibody immunity against Streptococcus pneumoniae stems from the ability of opsonic, serotype (ST)-specific antibodies to pneumococcal capsular polysaccharide (PPS) to facilitate killing of the homologous ST by host phagocytes. However, PPS-specific antibodies have been identified that are protective ...


    pub_type: 杂志文章


    authors: Fabrizio K,Manix C,Tian H,van Rooijen N,Pirofski LA

    更新日期:2010-11-03 00:00:00

  • Frequency of IFN-gamma producing cells correlates with adjuvant enhancement of bacille Calmette-Guèrin induced protection against Mycobacterium bovis.

    abstract::Tuberculosis caused by infection with Mycobacterium tuberculosis or Mycobacterium bovis remains one of the most important infectious diseases of man and animals. The current vaccine M. bovis Calmette-Guérin (BCG) demonstrates variable efficacy and so a more robust strategy to either replace, or more likely supplement ...


    pub_type: 杂志文章


    authors: Logan KE,Chambers MA,Hewinson RG,Hogarth PJ

    更新日期:2005-12-01 00:00:00

  • Incidence of narcolepsy before and after MF59-adjuvanted influenza A(H1N1)pdm09 vaccination in South Korean soldiers.

    abstract:BACKGROUND:Previous reports mostly from Europe suggested an association between an occurrence of narcolepsy and an influenza A(H1N1)pdm09 vaccine adjuvanted with AS03 (Pandemrix(®)). During the 2009 H1N1 pandemic vaccination campaign, the Korean military performed a vaccination campaign with one type of influenza vacci...


    pub_type: 杂志文章


    authors: Kim WJ,Lee SD,Lee E,Namkoong K,Choe KW,Song JY,Cheong HJ,Jeong HW,Heo JY

    更新日期:2015-09-11 00:00:00

  • Specific memory B cell response and participation of CD4+ central and effector memory T cells in mice immunized with liposome encapsulated recombinant NE protein based Hepatitis E vaccine candidate.

    abstract:BACKGROUND:Liposome encapsulated neutralizing epitope protein of Hepatitis E virus (HEV), rNEp, our Hepatitis E vaccine candidate, was shown to be immunogenic and safe in pregnant and non-pregnant mice and yielded sterilizing immunity in rhesus monkeys. METHODS:The current study in Balb/c mice assessed the levels and ...


    pub_type: 杂志文章


    authors: Kulkarni SP,Thanapati S,Arankalle VA,Tripathy AS

    更新日期:2016-11-21 00:00:00

  • In vivo evidence of immunological masking of the Vibrio cholerae O antigen of a hybrid Salmonella typhi Ty21a-Vibrio cholerae oral vaccine in humans.

    abstract::The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Forrest BD,LaBrooy JT

    更新日期:1991-07-01 00:00:00

  • Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity.

    abstract::Since the development of the first vaccine over 200 years ago, vaccines have saved millions of lives and have become the most cost-effective modern medical intervention. However, over 70 years ago, Freund recognized that the effectiveness of the vaccine-induced immune responses could be vastly improved via the co-deli...


    pub_type: 杂志文章,评审


    authors: Alter G,Sekaly RP

    更新日期:2015-06-08 00:00:00

  • An improved Pythium insidiosum-vaccine formulation with enhanced immunotherapeutic properties in horses and dogs with pythiosis.

    abstract::The immunotherapeutic properties of a new Pythium insidiosum-vaccine formulation (PIV), was evaluated in 18 horses and 6 dogs with proven pythiosis from different enzootic areas in the United States. All injected horses but one responded with a weak (=29 mm, n=3), a mild (30-90 mm, n=7) or a strong (=100 mm, n=7) infl...


    pub_type: 杂志文章


    authors: Mendoza L,Mandy W,Glass R

    更新日期:2003-06-20 00:00:00

  • Use of rubella seroepidemiological data for assessment of previous vaccination policy and for decision making in response to epidemics in Israel.

    abstract::We examined the prevalence of rubella antibodies in a representative sample of the Israeli population. Three thousand three hundred and twenty-six sera collected during 1997 and 1998, from an age-stratified general population sample were tested for specific IgG antibodies against rubella. The sero-positivity rates to ...


    pub_type: 杂志文章


    authors: Cohen D,Muhsen Kh,Aboudy Y,Harari H,Mendelson E,Green MS

    更新日期:2006-07-07 00:00:00

  • Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease.

    abstract::Serotype-specific protective immunity in pediatric patients with invasive pneumococcal disease (IPD) has not been fully investigated. To determine the protective immunity to the infecting serotype, the serotype-specific immunoglobulin G (IgG) levels and opsonization indices (OIs) were examined in 24 Japanese pediatric...


    pub_type: 杂志文章


    authors: Oishi T,Ishiwada N,Matsubara K,Nishi J,Chang B,Tamura K,Akeda Y,Ihara T,Nahm MH,Oishi K,Japanese IPD Study Group.

    更新日期:2013-01-21 00:00:00

  • How many published cases of serious adverse events after yellow fever vaccination meet Brighton Collaboration diagnostic criteria?

    abstract:OBJECTIVES:To perform a systematic review of all serious adverse events (SAEs) after yellow fever vaccination and to assess them according to Brighton Collaboration criteria. METHODS:Nine electronic databases were searched with the terms "yellow fever vaccine" and "adverse events" to 10 July 2013 (no language/date lim...


    pub_type: 杂志文章,评审


    authors: Thomas RE,Spragins W,Lorenzetti DL

    更新日期:2013-12-16 00:00:00

  • Improved haemagglutinin antigen content in H5N1 candidate vaccine viruses with chimeric haemagglutinin molecules.

    abstract::The candidate vaccine virus NIBRG-14 was derived by reverse genetics and comprises the haemagglutinin (HA) and neuraminidase (NA) genes derived from the clade 1 virus A/Viet Nam/1194/2004 on an A/Puerto Rico/8/34 (PR8) backbone. The HA gene was modified to remove the multibasic cleavage site motif associated with high...


    pub_type: 杂志文章


    authors: Harvey R,Nicolson C,Johnson RE,Guilfoyle KA,Major DL,Robertson JS,Engelhardt OG

    更新日期:2010-11-23 00:00:00

  • Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus.

    abstract::Respiratory syncytial virus F-protein (RSV-F) is poorly expressed from DNA expression plasmids containing the wild type RSV-F open reading frame. By codon optimization, premature polyadenylation signals were deleted and a striking enhancement of RSV-F expression levels was achieved. Therefore, the immunogenicity and e...


    pub_type: 杂志文章


    authors: Ternette N,Tippler B,Uberla K,Grunwald T

    更新日期:2007-10-10 00:00:00

  • Experimental immunisation and protection of guinea pigs with Vibrio cholerae toxoid and mucinases, neuraminidase and proteinase.

    abstract::As measured by fluid accumulation in ileal loops, Vibrio cholerae mucinase complex, with or without toxoid, protected guinea pigs from challenges with V. cholerae live organisms and enterotoxin. The neuraminidase and proteinases of the complex were combined in modified oil emulsion or aluminum hydroxide adjuvants and ...


    pub_type: 杂志文章


    authors: Stewart-Tull DE,Lucas C,Bleakley CR

    更新日期:2004-06-02 00:00:00

  • Tetanus immunity among Italians born after the introduction of mandatory vaccination of children.

    abstract::In Italy systematic mandatory tetanus immunization of children started in 1968. In a national sample of 241 young males born after 1968 the prevalence of non-immune subjects was 11.2% (5.5% in the North-Centre, 15.9% in the South-Islands; p < 0.02). Comparing these data with the corresponding figure obtained in a prev...


    pub_type: 杂志文章


    authors: D'Amelio R,Stroffolini T,Wirz M,Biselli R,Matricardi PM,Gentili G,Collotti C,Pasquini P

    更新日期:1993-01-01 00:00:00

  • Using immunization delivery strategies to accelerate progress in Africa towards achieving the Millennium Development Goals.

    abstract::Integration of health services brings together common functions within and between organizations to solve common problems, developing a commitment to a shared vision and goals, and using common technologies and resources to achieve these goals. Integration has been the frustrated rally call of Primary Health Care for ...


    pub_type: 杂志文章,评审


    authors: Clements CJ,Nshimirimanda D,Gasasira A

    更新日期:2008-04-07 00:00:00

  • Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE).

    abstract::Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligman, Gould, Lancet 2004;363:2073-5], it has little foundation [e.g., Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond J, Lang J, et al. Vaccine 2005;23:2956-8]. To invest...


    pub_type: 杂志文章


    authors: Pugachev KV,Schwaiger J,Brown N,Zhang ZX,Catalan J,Mitchell FS,Ocran SW,Rumyantsev AA,Khromykh AA,Monath TP,Guirakhoo F

    更新日期:2007-09-17 00:00:00

  • Phylogenetic and antigenic analyses of coxsackievirus A6 isolates in Yamagata, Japan between 2001 and 2017.

    abstract::Although coxsackievirus A6 (CV-A6) is generally recognized as a causative agent of herpangina in children, CV-A6 infections globally emerged as a new and major cause of epidemic hand-foot-and-mouth-diseases (HFMDs) around 2008. To clarify the longitudinal epidemiology of CV-A6, we carried out sequence and phylogenetic...


    pub_type: 杂志文章


    authors: Mizuta K,Tanaka S,Komabayashi K,Aoki Y,Itagaki T,Katsushima F,Katsushima Y,Yoshida H,Ito S,Matsuzaki Y,Ikeda T

    更新日期:2019-02-14 00:00:00

  • Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax.

    abstract::Plasmodium vivax is responsible for an approximate 35 million yearly human cases of malaria. Unfortunately, due to the low mortality rate associated with it and the difficulties of continuously in vitro culturing of this parasite, vaccine development against this human malaria has been largely neglected. In here, the ...


    pub_type: 杂志文章


    authors: de Oliveira CI,Wunderlich G,Levitus G,Soares IS,Rodrigues MM,Tsuji M,del Portillo HA

    更新日期:1999-08-06 00:00:00

  • Levels of antibodies specific to diphtheria toxoid, tetanus toxoid, and Haemophilus influenzae type b in healthy children born to Tdap-vaccinated mothers.

    abstract:INTRODUCTION:Vaccination of pregnant women protects both women and their newborns against some infectious diseases. Thailand implemented tetanus toxoid (TT) vaccination of pregnant women in 1977, which was replaced by tetanus-diphtheria toxoid (dT) vaccination in 2005. The tetanus-diphtheria-acellular pertussis (Tdap) ...


    pub_type: 杂志文章


    authors: Wanlapakorn N,Maertens K,Thongmee T,Srimuan D,Thatsanathorn T,Van Damme P,Leuridan E,Poovorawan Y

    更新日期:2020-10-14 00:00:00

  • Antibody response to 7-valent conjugated pneumococcal vaccine in patients with chronic lymphocytic leukaemia.

    abstract::Chronic lymphocytic leukaemia (CLL) is a common adulthood mature B-cell neoplasm. Infections are the most important cause of mortality in this condition, and Streptococcus pneumoniae has been considered the most important single pathogen. We investigated the immunogenicity of 7-valent pneumococcal conjugate vaccine in...


    pub_type: 杂志文章


    authors: Sinisalo M,Vilpo J,Itälä M,Väkeväinen M,Taurio J,Aittoniemi J

    更新日期:2007-12-21 00:00:00

  • Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines.

    abstract::Scorpions and other venomous animals contain concentrates of biologically active substances developed to block vital physiological and biochemical functions of the victims. These have contrasting human health concerns, provide important pharmacological raw material and pose a serious threat to human life and health in...


    pub_type: 杂志文章,评审


    authors: Gazarian KG,Gazarian T,Hernández R,Possani LD

    更新日期:2005-05-16 00:00:00

  • Human papillomavirus vaccine effectiveness by number of doses: Systematic review of data from national immunization programs.

    abstract:BACKGROUND:Human papillomavirus (HPV) vaccines were first licensed as a three-dose series; a two-dose series is now recommended in some age groups and there is interest in possible one-dose vaccination. METHODS:We conducted a systematic literature review of HPV vaccine effectiveness by number of doses, including asses...


    pub_type: 杂志文章,评审


    authors: Markowitz LE,Drolet M,Perez N,Jit M,Brisson M

    更新日期:2018-08-06 00:00:00

  • Comparison of pertussis surveillance systems in Europe.

    abstract::We compared pertussis surveillance systems of 16 European countries in the period 1998-2002. In twelve out of sixteen countries the system covered the general population. Ten countries relied on WHO case definition for surveillance of pertussis. Eleven countries applied laboratory tests, and eight of them used PCR for...


    pub_type: 杂志文章


    authors: Tozzi AE,Pandolfi E,Celentano LP,Massari M,Salmaso S,Ciofi degli Atti ML,EUVAC-NET Study Group.

    更新日期:2007-01-04 00:00:00

  • Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age.

    abstract:BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Izikson R,Leffell DJ,Bock SA,Patriarca PA,Post P,Dunkle LM,Cox MM

    更新日期:2015-11-27 00:00:00

  • Immunization with the Chlamydia trachomatis major outer membrane protein, using adjuvants developed for human vaccines, can induce partial protection in a mouse model against a genital challenge.

    abstract::To test several vaccines for Chlamydia trachomatis we vaccinated BALB/c and C3H/HeN female mice with a purified preparation of the native mouse pneumonitis (MoPn) major outer membrane protein (MOMP). The MOMP was formulated with anyone of three different adjuvants MF59, LT-K63 or LT-R72. As a negative control the anim...


    pub_type: 杂志文章


    authors: Pal S,Peterson EM,Rappuoli R,Ratti G,de la Maza LM

    更新日期:2006-02-06 00:00:00

  • Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice.

    abstract::Dendritic cells (DCs) have been identified as the most effective antigen-presenting cell (APC), much attention has been directed toward the use of DCs in vaccine strategies for the treatment of cancer or chronic virus infection. B7-H1 (PD-L1) is a ligand for programmed cell death-1 (PD-1) and does not bind to other CD...


    pub_type: 杂志文章


    authors: Jiang W

    更新日期:2012-01-17 00:00:00

  • A comparative study of PENTA vaccine booster doses given at 12, 15, or 18 months of age.

    abstract::For infants immunized with Haemophilus influenzae type b conjugate vaccines, booster immunization is usually recommended in the second year of life, typically between 12 and 18 months. This study assessed the effect of age at booster immunization on pre-immunization antibody trough levels and on subsequent responses, ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scheifele DW,Guasparini R,Lavigne P

    更新日期:1999-02-12 00:00:00

  • In vivo protein expression and immune responses generated by DNA vaccines expressing mycobacterial antigens fused with a reporter protein.

    abstract::We cloned six mycobacterial antigens into a mammalian expression vector as fusion proteins with the enhanced green fluorescent protein (EGFP). Plasmid DNA was injected intramuscularly, and the injection sites were examined 1 week later. Expression of each antigen-EGFP fusion protein was visualized as green fluorescenc...


    pub_type: 杂志文章


    authors: Quinn A,Jiang W,Velaz-Faircloth M,Cobb AJ,Henry SC,Frothingham R

    更新日期:2002-08-19 00:00:00

  • Can the response to 23-valent pneumococcal vaccine in splenectomised patients be predicted?

    abstract::The 23-valent pneumococcal vaccine has unequal effectiveness in splenectomised patients. We performed a longitudinal study (2005-2008) whose main objective was to characterize the profile of non-responders among splenectomised patients treated at our institution and identify potential predictive indicators of the resp...


    pub_type: 杂志文章


    authors: Llupià A,Vilella A,Costas L,Díez C,Torres F,Yagüe J,Massó M,Muñoz A,Mensa J

    更新日期:2012-03-16 00:00:00