Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus.


:With the aim of studying the molecular diversity of the antigens of a new recombinant vaccine against meningococcus serogroup B, the three genes coding for the main vaccine components GNA (Genome-derived Neisseria Antigen) 1870 (fHbp, factor H Binding Protein), GNA1994 (NadA, Neisseria adhesin A) and GNA2132 were sequenced in a panel of 85 strains collected worldwide and selected as representative of the serogroup B meningococcal diversity. No correlations were found between vaccine antigen variability and serogroup, geographic area and year of isolation. Although a relevant clustering was found with MLST clonal complexes, each showing an almost specific antigen variant repertoire, the prediction of the antigen assortment was not possible on the basis of MLST alone. Therefore, classification of meningococcus on the basis of MLST only is not sufficient to predict vaccine antigens diversity. Sequencing each gene in the different strains will be important to evaluate antigen conservation and assortment and to allow a future prediction of potential vaccine coverage.






Bambini S,Muzzi A,Olcen P,Rappuoli R,Pizza M,Comanducci M




Has Abstract


2009-05-11 00:00:00
















  • The age-dependent risk of postvaccination complications in vaccinees with smallpox vaccine.

    abstract::The use of vaccinia virus in recombinant systems may result in the occurrence of complications observed following smallpox vaccination. The results are presented of a large survey carried out in the USSR between 1968 and 1979. High complication rates are reported, particularly in older primary vaccinees; for example, ...


    pub_type: 杂志文章


    authors: Gurvich EB

    更新日期:1992-01-01 00:00:00

  • Humoral immunity against tick-borne encephalitis virus following manifest disease and active immunization.

    abstract::Humoral immunity against tick-borne encephalitis virus (TBEV) in patients with a well-documented history of naturally acquired tick-borne encephalitis (TBE) was compared with immunity resulting from vaccination in a carefully controlled immunization programme. The vaccination study was performed with a highly purified...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Klockmann U,Bock HL,Kwasny H,Praus M,Cihlová V,Tomková E,Krivanec K

    更新日期:1991-01-01 00:00:00

  • Safety and immunological efficacy of a prostate cancer plasmid DNA vaccine encoding prostatic acid phosphatase (PAP).

    abstract::Prostatic acid phosphatase (PAP) is a prostate tumor antigen currently being investigated as a target antigen in several human vaccine trials, some with evidence of clinical benefit. We have previously demonstrated that plasmid DNA vaccines encoding either human or rat PAP can elicit antigen-specific cellular and humo...


    pub_type: 杂志文章


    authors: Johnson LE,Frye TP,Arnot AR,Marquette C,Couture LA,Gendron-Fitzpatrick A,McNeel DG

    更新日期:2006-01-16 00:00:00

  • Co-delivery of plasmid-encoded cytokines modulates the immune response to a DNA vaccine delivered by in vivo electroporation.

    abstract::In this study, in vivo electroporation of a DNA vaccine adjuvanted with plasmids encoding different cytokines was investigated in large animals. Sheep were injected intramuscularly with a DNA vaccine encoding an antigen of Haemonchus contortus (pNPA) and plasmids encoding different cytokines followed by in vivo electr...


    pub_type: 杂志文章


    authors: Yen HH,Scheerlinck JP

    更新日期:2007-03-30 00:00:00

  • Vaccination for control of Salmonella in poultry.

    abstract::Salmonella spp. are facultative intracellular pathogens causing localised or systemic infections, in addition to a chronic asymptomatic carrier state. They are of worldwide economic and public health significance. In poultry, which represent important sources of cheap protein throughout the world, fowl typhoid and pul...


    pub_type: 杂志文章,评审


    authors: Zhang-Barber L,Turner AK,Barrow PA

    更新日期:1999-06-04 00:00:00

  • Identification of Setaria cervi heat shock protein 70 by mass spectrometry and its evaluation as diagnostic marker for lymphatic filariasis.

    abstract::Using mass spectrometry and immunological approaches, a heat shock protein 70 associated with lymphatic filariasis (LF) has been identified from a bovine filarial parasite Setaria cervi. A heat shock protein was detected in different life stages of S. cervi when exposed to an elevated temperature of 44 degrees C. A co...


    pub_type: 杂志文章


    authors: Srivastava S,Srikanth E,Liebau E,Rathaur S

    更新日期:2010-02-03 00:00:00

  • Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody.

    abstract::The ability to protect mice against respiratory infections with virulent Francisella tularensis has been problematic and the role of antibody-versus-cell-mediated immunity controversial. In this study, we tested the hypothesis that protective immunity can develop in mice that were given antibiotic therapy following in...


    pub_type: 杂志文章


    authors: Klimpel GR,Eaves-Pyles T,Moen ST,Taormina J,Peterson JW,Chopra AK,Niesel DW,Carness P,Haithcoat JL,Kirtley M,Nasr AB

    更新日期:2008-12-09 00:00:00

  • Tuberculosis subunit vaccine development: impact of physicochemical properties of mycobacterial test antigens.

    abstract::Tuberculosis caused by Mycobacterium tuberculosis continues to be one of the major public health problems in the world. The eventual control of this disease will require the development of a safe and effective vaccine. One of the approaches receiving a great deal of attention recently is subunit vaccination. An effica...


    pub_type: 杂志文章,评审


    authors: Sable SB,Plikaytis BB,Shinnick TM

    更新日期:2007-02-19 00:00:00

  • Studies on recombinant glucokinase (r-glk) protein of Brucella abortus as a candidate vaccine molecule for brucellosis.

    abstract::Brucellosis is one of the most prevalent zoonotic diseases of worldwide distribution caused by the infection of genus Brucella. Live attenuated vaccines such as B. abortus S19, B. abortus RB51 and B. melitensis Rev1 are found most effective against brucellosis infection in animals, contriving a number of serious side ...


    pub_type: 杂志文章


    authors: Vrushabhendrappa,Singh AK,Balakrishna K,Sripathy MH,Batra HV

    更新日期:2014-09-29 00:00:00

  • Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques.

    abstract::Respiratory mucosa immunization is capable of eliciting both local and distal mucosal immune responses; it is a potentially powerful yet largely unused modality for vaccination against respiratory diseases. Targeting the lower versus upper airways by aerosol delivery alters the immunogenicity profile of a vaccine, alt...


    pub_type: 杂志文章


    authors: Bolton DL,Song K,Tomaras GD,Rao S,Roederer M

    更新日期:2017-01-23 00:00:00

  • Immunization of human hepatitis E viruses conferred protection against challenge by a camel hepatitis E virus.

    abstract::Dromedary camel hepatitis E virus is a novel HEV that belongs to the family Hepeviridae, and is classified as genotype 7 HEV (HEV-7). Since HEV-7 is transmitted from camels to humans and causes acute hepatitis E, this virus is a non-negligible pathogen for zoonosis, and a vaccine against HEV-7 infection is urgently ne...


    pub_type: 杂志文章


    authors: Guo Y,Yang F,Xu X,Feng M,Liao Y,He Z,Takeda N,Muramatsu M,Li Q,Li TC

    更新日期:2020-10-27 00:00:00

  • A malaria vaccine for travelers and military personnel: Requirements and top candidates.

    abstract::Malaria remains an important health threat to non-immune travelers with the explosive growth of global travel. Populations at high risk of acquiring malaria infections include once semi-immune travelers who visit friends and relatives, military forces, business travelers and international tourists with destinations to...


    pub_type: 杂志文章


    authors: Teneza-Mora N,Lumsden J,Villasante E

    更新日期:2015-12-22 00:00:00

  • A humanized monoclonal antibody targeting Staphylococcus aureus.

    abstract::This current presentation describes the in vitro and in vivo characterization of Aurexis (tefibazumab), a humanized monoclonal antibody that exhibits a high affinity and specificity and for the Staphylococcus aureus MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) protein ClfA. Aurexis inhi...


    pub_type: 杂志文章,评审


    authors: Patti JM

    更新日期:2004-12-06 00:00:00

  • Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara.

    abstract::The immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag-pol, nef, rev, and tat genes (MVA-SIVmac) or primed with a Semliki...


    pub_type: 杂志文章


    authors: Nilsson C,Mäkitalo B,Berglund P,Bex F,Liljeström P,Sutter G,Erfle V,ten Haaft P,Heeney J,Biberfeld G,Thorstensson R

    更新日期:2001-05-14 00:00:00

  • Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers.

    abstract:OBJECTIVE:Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. DESIGN:German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux) in an open-label study. Blood samples were taken before (n=261...


    pub_type: 临床试验,杂志文章


    authors: Littmann M,Hülsse C,Riffelmann M,Wirsing von König CH

    更新日期:2008-05-02 00:00:00

  • HPV infections among young MSM visiting sexual health centers in the Netherlands: Opportunities for targeted HPV vaccination.

    abstract:INTRODUCTION:In 2009, girls-only HPV16/18 vaccination was introduced in the Netherlands which has achieved 46-61% uptake. Heterosexual men have benefitted from herd protection, but it is unknown whether men who have sex with men (MSM) also benefit from herd effects of the girls-only HPV16/18 vaccination program. Becaus...


    pub_type: 杂志文章


    authors: Woestenberg PJ,van Benthem BHB,Bogaards JA,King AJ,van der Klis FRM,Pasmans H,Leussink S,van der Sande MAB,Hoebe CJPA,Medical Microbiological Laboratories, the Public Health Services.

    更新日期:2020-04-09 00:00:00

  • Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China.

    abstract::Vaccines are needed to control zoonotic Schistosoma japonicum infection and several vaccine candidates have now been identified. Two of these (Sj28GST and Sj23) have shown particular promise in sheep when injected with Freund's adjuvants. The objective of the present work was to find a vaccine formulation which may ha...


    pub_type: 杂志文章


    authors: Shi F,Zhang Y,Ye P,Lin J,Cai Y,Shen W,Bickle QD,Taylor MG

    更新日期:2001-11-12 00:00:00

  • Conformational restriction of peptidyl immunogens with covalent replacements for the hydrogen bond.

    abstract::A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...


    pub_type: 杂志文章,评审


    authors: Satterthwait AC,Arrhenius T,Hagopian RA,Zavala F,Nussenzweig V,Lerner RA

    更新日期:1988-04-01 00:00:00

  • Validity of self-reported pneumococcal vaccination status in the elderly in Spain.

    abstract::The objective of this study was to evaluate the validity of information reported by the elderly on 23-valent pneumococcal polysaccharide vaccine (23vPPV) vaccination status. A cross-sectional, observational study was carried out in patients aged >or=65 years admitted to five Spanish hospitals. Data on 23vPPV vaccinati...


    pub_type: 杂志文章


    authors: Bayas JM,Izquierdo C,Ruiz L,Sintes X,Sousa D,Celorrio JM,Varona W,Carratalà J,Nebot M,Batalla J,Sugrañes S,Manzur A,Terren A,García C,Clemente E,Rivera S,Justo I,Arévalo A,Salleras L,Domínguez A

    更新日期:2009-07-23 00:00:00

  • Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects.

    abstract::To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 microg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 microg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only lo...


    pub_type: 杂志文章,随机对照试验


    authors: Couch RB,Winokur P,Brady R,Belshe R,Chen WH,Cate TR,Sigurdardottir B,Hoeper A,Graham IL,Edelman R,He F,Nino D,Capellan J,Ruben FL

    更新日期:2007-11-01 00:00:00

  • Immunisation practices in centres caring for children with perinatally acquired HIV: A call for harmonisation.

    abstract:BACKGROUND:Current national immunisation schedules differ between countries in terms of vaccine formulation, timing of vaccinations and immunisation programme funding and co-ordination. As a result, some HIV infected paediatric population may be left susceptible to vaccine preventable infections. Vaccines used in healt...


    pub_type: 杂志文章,多中心研究


    authors: Bamford A,Manno EC,Mellado MJ,Spoulou V,Marques L,Scherpbier HJ,Niehues T,Oldakowska A,Rossi P,Palma P,PENTA-vac Group.

    更新日期:2016-11-04 00:00:00

  • Immunogenicity and safety of human papillomavirus vaccine coadministered with other vaccines in individuals aged 9-25 years: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Adolescents and young adults are at a high risk of developing human papillomavirus (HPV) infections, which can be prevented with the use of vaccines. Moreover, a combined immunization strategy for administration of HPV vaccines with other routine vaccines may lead to better compliance. We aim to comprehens...


    pub_type: 杂志文章,评审


    authors: Li Y,Zhu P,Wu M,Zhang Y,Li L

    更新日期:2020-01-10 00:00:00

  • Phenotypic and functional characterization of T-cells and in vitro replication of FMDV serotypes in bovine lymphocytes.

    abstract::Peripheral blood mononuclear cells (PBMCs) from unvaccinated and vaccinated bovine calves were employed to study the alteration of different T-cell subpopulations, functional competence and detection of foot-and-mouth disease virus (FMDV) at different hours post in vitro infection (hpi) with FMDV serotype either O or ...


    pub_type: 杂志文章


    authors: Joshi G,Sharma R,Kakker NK

    更新日期:2009-11-12 00:00:00

  • Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan.

    abstract::During the endgame of global polio eradication, the universal introduction of inactivated poliovirus vaccines is urgently required to reduce the risk of vaccine-associated paralytic poliomyelitis and polio outbreaks due to wild and vaccine-derived polioviruses. In particular, the development of inactivated poliovirus ...


    pub_type: 历史文章,杂志文章,评审


    authors: Shimizu H

    更新日期:2016-04-07 00:00:00

  • A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibody response to Haemophilus influenzae type b CRM(197) conjugate vaccine.

    abstract::CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria tox...


    pub_type: 杂志文章,随机对照试验


    authors: Usonis V,Bakasenas V,Lockhart S,Baker S,Gruber W,Laudat F

    更新日期:2008-08-18 00:00:00

  • Association of HLA class II genes with clinical hyporesponsiveness to trivalent inactivated influenza vaccine in children.

    abstract:BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...


    pub_type: 杂志文章


    authors: Narwaney KJ,Glanz JM,Norris JM,Fingerlin TE,Hokanson JE,Rewers M,Hambidge SJ

    更新日期:2013-02-04 00:00:00

  • Rationale and design of a community-based double-blind randomized clinical trial of an HPV 16 and 18 vaccine in Guanacaste, Costa Rica.

    abstract::We report the rationale, design, methods and details of participation of a community-based, double-blind, randomized clinical trial of an HPV 16 and 18 vaccine conducted in two provinces of Costa Rica to investigate the efficacy and population impact of the vaccine in the prevention of cervical cancer precursors. More...


    pub_type: 杂志文章,随机对照试验


    authors: Herrero R,Hildesheim A,Rodríguez AC,Wacholder S,Bratti C,Solomon D,González P,Porras C,Jiménez S,Guillen D,Morales J,Alfaro M,Cyr J,Morrisey K,Estrada Y,Cortés B,Morera LA,Freer E,Schussler J,Schiller J,Lowy D,S

    更新日期:2008-09-02 00:00:00

  • A double-blind, placebo-controlled trial to evaluate the efficacy of PTL-003, an attenuated enterotoxigenic E. coli (ETEC) vaccine strain, in protecting against challenge with virulent ETEC.

    abstract::Enterotoxigenic E. coli (ETEC) are an important cause of diarrhea in developing countries, especially among indigenous children and travelers. In this randomized, double-blind, placebo-controlled trial, a live, attenuated CS1/CS3 ETEC strain, PTL-003, was tested as a potential vaccine strain. Thirty-three subjects dra...


    pub_type: 杂志文章,随机对照试验


    authors: McKenzie R,Darsley M,Thomas N,Randall R,Carpenter C,Forbes E,Finucane M,Sack RB,Hall E,Bourgeois AL

    更新日期:2008-08-26 00:00:00

  • Protection against establishment of latent infections in mice immunized with a non-pathogenic herpes simplex virus mutant and reinfected with the pathogenic parental strain.

    abstract::Immunization of hairless mice with a TK-, ACVr, non-pathogenic herpes simplex virus (HSV) type 1 mutant protected the mice against reinfection with lethal doses of the parental pathogenic HSV strain. The protection conferred by the mutant against the establishment of latency after reinfection with the parental strain ...


    pub_type: 杂志文章


    authors: Klein RJ,Kaley LA,Friedman-Kien AE

    更新日期:1984-09-01 00:00:00

  • Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis.

    abstract::Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia coli induced protective immune responses. In this study, we report that oral DNA vaccination with attenuated Salmonella choleraesuis carrying the PrV gD gene conferred protective immunity in mi...


    pub_type: 杂志文章


    authors: Shiau AL,Chen YL,Liao CY,Huang YS,Wu CL

    更新日期:2001-07-16 00:00:00