当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Critical issues in cancer vaccine trial design.

Critical issues in cancer vaccine trial design.

Abstract：

:As the clinical experience with cancer vaccines and cancer immunotherapy increases, there are important lessons that can be learned from the successes and failures of past trials. Many lessons affect the design and conduct of clinical trials themselves. Appropriate patient selection, clinical trial design, immunologic monitoring, and appropriate endpoints are all essential to the efficiency and success of bringing cancer vaccines from conception to clinical use.

journal_name

Vaccine

journal_title

Vaccine

authors

Clifton GT,Kohrt HE,Peoples GE

doi

10.1016/j.vaccine.2015.09.019

subject

Has Abstract

pub_date

2015-12-16 00:00:00

pages

7386-7392

issue

51

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(15)01280-3

journal_volume

33

pub_type

杂志文章,评审

相关文献

VACCINE文献大全
  • TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7.

    abstract：:Toll-like receptors 7 (TLR7) and 8 (TLR8) recognize viral single-stranded RNA and small molecular weight agonists to activate anti-viral immune responses. TLR8s from different species have distinct ligand recognitions. For example, human TLR8 is responsive to ligand stimulation, but mouse and rat TLR8 are activated by...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.07.104

    authors： Lai CY,Liu YL,Yu GY,Maa MC,Leu TH,Xu C,Luo Y,Xiang R,Chuang TH

    更新日期：2014-09-29 00:00:00

  • Characterization of foot-and-mouth disease virus from outbreaks in Ecuador during 2009-2010 and cross-protection studies with the vaccine strain in use in the region.

    abstract：:During the years 2009 and 2010 relevant epidemic waves of foot-and-mouth disease (FMD) serotype O occurred in Ecuador, representing a great drawback for the last stages of the ongoing eradication program in South America. This study describes the molecular and antigenic characterizations of 29 isolates collected from ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.08.120

    authors： Maradei E,Perez Beascoechea C,Malirat V,Salgado G,Seki C,Pedemonte A,Bonastre P,D'Aloia R,La Torre JL,Mattion N,Rodríguez Toledo J,Bergmann IE

    更新日期：2011-10-26 00:00:00

  • Estimating the vaccine-preventable burden of hospitalized pneumonia among young Mozambican children.

    abstract：:Polysaccharide-protein conjugate vaccines against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae have proven efficacy against radiologically confirmed pneumonia. Measurement of pneumonia incidence provides a platform to estimate of the vaccine-preventable burden. Over 24 months, we conducted surveill...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.03.060

    authors： Roca A,Sigaúque B,Quintó L,Morais L,Berenguera A,Corachan M,Ribó JL,Naniche D,Bassat Q,Sacoor Ch,Nhalungo D,Macete E,Schuchat A,Soriano-Gabarró M,Flannery B,Alonso PL

    更新日期：2010-07-05 00:00:00

  • Bacillus Calmette-Guérin (BCG) vaccine generates immunoregulatory cells in the cervical lymph nodes in guinea pigs injected intra dermally.

    abstract：:This work demonstrates the presence of immune regulatory cells in the cervical lymph nodes draining Bacillus Calmette-Guérin (BCG) vaccinated site on the dorsum of the ear in guinea pigs. It is shown that whole cervical lymph node cells did not proliferate in vitro in the presence of soluble mycobacterial antigens (PP...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.10.009

    authors： Vergkizi S,Nikolakakis I

    更新日期：2020-11-10 00:00:00

  • The immune response to a two-dose schedule of quadrivalent HPV vaccine in 9-13 year-old girls: Is it influenced by age, menarche status or body mass index?

    abstract：:HPV vaccines are highly immunogenic. A two-dose schedule for 9-14 year-old is recommended. However, no data exist regarding the impact of age, menarche status and body mass index (BMI) on the immune response to a two-dose schedule. In this post-hoc analysis, we present antibody titers to HPV6/11/16/18 in 9-13 year-old...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2019.09.089

    authors： Sauvageau C,Gilca V,Donken R,Fan SY,Ogilvie G,Dobson S

    更新日期：2019-11-20 00:00:00

  • Synthetic peptides induce antibody against a host-protective antigen of Echinococcus granulosus.

    abstract：:The immunogenicity of four synthetic peptides was investigated in sheep. The sequences of the peptides (6, 12/13, 21/22 and 24) were derived from linear, antibody-binding epitopes of the EG95 recombinant protein, a host-protective antigen of the parasite Echinococcus granulosus. Sheep were immunised with either free p...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00350-3

    authors： Woollard DJ,Gauci CG,Lightowlers MW

    更新日期：1999-12-10 00:00:00

  • Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice.

    abstract：:Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immun...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.040

    authors： Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

    更新日期：2009-08-06 00:00:00

  • Large-scale influenza vaccination promotion on a mobile app platform: A randomized controlled trial.

    abstract：:While health-care providers have used incentives in an attempt to motivate patients to obtain vaccinations, their effect on vaccination rates has not been systematically evaluated on a large scale. In this study, we examined whether mobile applications may improve population vaccination rates through enhanced communic...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.11.053

    authors： Lee WN,Stück D,Konty K,Rivers C,Brown CR,Zbikowski SM,Foschini L

    更新日期：2020-04-16 00:00:00

  • The fight against rabies in Africa: From recognition to action.

    abstract：:As a follow-up to the first AfroREB meeting, held in Grand Bassam (Côte d'Ivoire) in March 2008, African rabies experts of the AfroREB network met a second time to complete the evaluation of the rabies situation in Africa and define specific action plans. About 40 French speaking rabies specialists from northern, west...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.030

    authors： Dodet B,Africa Rabies Bureau (AfroREB).

    更新日期：2009-08-13 00:00:00

  • Interferon-gamma-inducing oral vaccination with Leishmania amazonensis antigens protects BALB/c and C57BL/6 mice against cutaneous leishmaniasis.

    abstract：:The induction of oral tolerance against disease-inducing antigens has emerged as a feasible strategy to prevent immunopathologies. In this study, we investigated the effect of oral immunization with whole antigens of Leishmania amazonensis promastigotes (LaAg) on murine cutaneous leishmaniasis. We found that two oral ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00427-4

    authors： Pinto EF,de Mello Cortezia M,Rossi-Bergmann B

    更新日期：2003-09-08 00:00:00

  • Distribution of adsorbed antigen in mono-valent and combination vaccines.

    abstract：:The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Ad...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.10.040

    authors： Morefield GL,HogenEsch H,Robinson JP,Hem SL

    更新日期：2004-05-07 00:00:00

  • Identification of Setaria cervi heat shock protein 70 by mass spectrometry and its evaluation as diagnostic marker for lymphatic filariasis.

    abstract：:Using mass spectrometry and immunological approaches, a heat shock protein 70 associated with lymphatic filariasis (LF) has been identified from a bovine filarial parasite Setaria cervi. A heat shock protein was detected in different life stages of S. cervi when exposed to an elevated temperature of 44 degrees C. A co...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.06.044

    authors： Srivastava S,Srikanth E,Liebau E,Rathaur S

    更新日期：2010-02-03 00:00:00

  • Systematic review of reporting rates of adverse events following immunization: an international comparison of post-marketing surveillance programs with reference to China.

    abstract：BACKGROUND:China is the most populous country in the world, with an annual birth cohort of approximately 16 million, requiring an average of 500 million vaccine doses administered annually. In China, over 30 domestic and less than 10 overseas vaccine manufacturers supply over 60 licensed vaccine products, representing ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2012.11.051

    authors： Guo B,Page A,Wang H,Taylor R,McIntyre P

    更新日期：2013-01-11 00:00:00

  • Evaluation of safety and immunogenicity of recombinant influenza hemagglutinin (H5/Indonesia/05/2005) formulated with and without a stable oil-in-water emulsion containing glucopyranosyl-lipid A (SE+GLA) adjuvant.

    abstract：BACKGROUND:Expression of recombinant hemagglutinin (rHA) in insect cells represents a technology with proven efficacy in seasonal influenza and with the potential for a rapid response to the emergence of new, pandemic strains. We evaluated the safety and immunogenicity of rHA vaccine (H5/Indonesia/5/05) produced in SF+...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2013.08.064

    authors： Treanor JJ,Essink B,Hull S,Reed S,Izikson R,Patriarca P,Goldenthal KL,Kohberger R,Dunkle LM

    更新日期：2013-11-19 00:00:00

  • Beneficiary characteristics and vaccinations in the end-stage renal disease Medicare beneficiary population, an analysis of claims data 2006-2015.

    abstract：BACKGROUND:The Advisory Committee on Immunization Practices (ACIP) routinely recommends three vaccines - influenza, hepatitis B, and pneumococcal vaccines - for End-Stage Renal Disease (ESRD) dialysis patients. METHODS:We sought to assess vaccination coverage among fee-for-service (FFS) Medicare beneficiaries with ESR...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.105

    authors： Shen AK,Kelman JA,Warnock R,Zhang W,Brereton S,McKean S,Wernecke M,Chu S,Gellin BG

    更新日期：2017-12-19 00:00:00

  • Characterization of a novel live attenuated infectious bronchitis virus vaccine candidate derived from a Korean nephropathogenic strain.

    abstract：:A nephropathogenic K2/01 strain of infectious bronchitis virus (IBV) was attenuated by 170 serial passages in embryonated chicken eggs for possible use as a future IBV vaccine strain. High-growth properties and narrow tissue tropisms (limited replication in respiratory tracts) were achieved by the adaptation process. ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.01.062

    authors： Lee HJ,Youn HN,Kwon JS,Lee YJ,Kim JH,Lee JB,Park SY,Choi IS,Song CS

    更新日期：2010-04-01 00:00:00

  • Live oral typhoid vaccine Salmonella Typhi Ty21a - a surrogate vaccine against non-typhoid salmonella?

    abstract：BACKGROUND:Non-typhoid Salmonella (NTS) is a leading cause of food-borne illness with more than 90 million annual cases and an emerging antimicrobial resistance among the strains worldwide. Paradoxically, no vaccines are available against these pathogens. Numerous NTS strains share surface O-antigens with Salmonella en...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.10.002

    authors： Kantele A,Pakkanen SH,Siitonen A,Karttunen R,Kantele JM

    更新日期：2012-11-26 00:00:00

  • Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China.

    abstract：:Vaccines are needed to control zoonotic Schistosoma japonicum infection and several vaccine candidates have now been identified. Two of these (Sj28GST and Sj23) have shown particular promise in sheep when injected with Freund's adjuvants. The objective of the present work was to find a vaccine formulation which may ha...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00340-1

    authors： Shi F,Zhang Y,Ye P,Lin J,Cai Y,Shen W,Bickle QD,Taylor MG

    更新日期：2001-11-12 00:00:00

  • Inactivated influenza vaccine does not reduce all cause respiratory illness in children with pre-existing medical conditions.

    abstract：BACKGROUND:The effectiveness of inactivated influenza vaccine (IIV) immunization in preventing all cause respiratory illness (RI) in children with pre-existing medical conditions has not been fully established and varies from season to season. This study aims to quantify the overall impact of IIV immunization on primar...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.11.086

    authors： de Hoog MLA,Venekamp RP,Meijer A,Sanders EAM,Bruijning-Verhagen PCJL

    更新日期：2020-04-09 00:00:00

  • Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals.

    abstract：:We evaluated immunologic predictors of response to HBV vaccine administered in the presence or absence of GM-CSF in HIV infected individuals. We measured peripheral blood hematopoietic progenitor, monocyte and myeloid-derived suppressor cell (MDSC) frequencies, and expression of GMCSF receptor on monocytes and MDSCs, ...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2011.02.092

    authors： Anthony DD,Umbleja T,Aberg JA,Kang M,Medvik K,Lederman MM,Peters MG,Koziel MJ,Overton ET

    更新日期：2011-04-27 00:00:00

  • Preparation-free method can enable rapid surfactant screening during industrial processing of influenza vaccines.

    abstract：:Triton X-100 (TX-100) is the most common surfactant used to split viruses during the production of influenza split-virus vaccines. It is a mild surfactant not known to denature the viral proteins; this property makes TX-100 useful for maintaining antigen conformational structure, and, as an added benefit, for partiall...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.12.069

    authors： Sahin Z,Neeleman R,Haines J,Kayser V

    更新日期：2019-02-14 00:00:00

  • Safety, immunogenicity, and kinetics of the immune response to a single dose of virosome-formulated hepatitis A vaccine in Thais.

    abstract：:The safety and immunogenicity of a single dose of virosome-formulated hepatitis A vaccine was evaluated in healthy seronegative Thai volunteers. Immunization elicited primarily mild transient reactions which did not interfere with normal activities. All subjects possessed > 20 mIU of anti-hepatitis A virus antibody pe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)00007-n

    authors： Poovorawan Y,Theamboonlers A,Chumdermpadetsuk S,Glück R,Cryz SJ Jr

    更新日期：1995-07-01 00:00:00

  • Safety and immunogenicity of measles-mumps-rubella vaccine in children with congenital immunodeficiency (DiGeorge syndrome).

    abstract：:Live attenuated vaccines are usually contraindicated in patients with congenital or acquired immunodeficiency. On the other hand, infections due to wild type virus may be particularly severe in patients with low levels of T cells. The aim of the present study was to evaluate safety and immunogenicity of measles-mumps-...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.10.005

    authors： Azzari C,Gambineri E,Resti M,Moriondo M,Betti L,Saldias LR,G Gelli AM,Vierucci A

    更新日期：2005-02-25 00:00:00

  • From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination.

    abstract：:Although studies have suggested that a patient's perceived cost-benefit of a medical intervention could affect his or her utilization of the intervention, the economic value of influenza vaccine from the patient's perspective remains unclear. Therefore, we developed a stochastic decision analytic computer model repres...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.12.078

    authors： Lee BY,Bacon KM,Donohue JM,Wiringa AE,Bailey RR,Zimmerman RK

    更新日期：2011-03-03 00:00:00

  • A comparative study on the safety and immunogenicity of Purified duck embryo vaccine [corrected] (PDEV, Vaxirab) with purified chick embryo cell vaccine (PCEC, Rabipur) and purifed vero cell rabies vaccine (PVRV, Verorab).

    abstract：:Rabies is a fatal but preventable disease. Cell culture vaccines (CCV) and purified duck embryo vaccines (PDEV) are currently recommended by WHO for post-exposure prophylaxis. In India, a PDEV (Vaxirab) is being manufactured and is in use since 2003. In the present study, we have evaluated the safety, immunogenicity a...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2009.09.090

    authors： Ashwathnarayana DH,Madhusudana SN,Sampath G,Sathpathy DM,Mankeshwar R,Ravish HH,Ullas PT,Behra TR,Sudarshan MK,Gangaboraiah,Shamanna M

    更新日期：2009-12-10 00:00:00

  • Safety of Russian-backbone seasonal trivalent, live-attenuated influenza vaccine in a phase II randomized placebo-controlled clinical trial among children in urban Bangladesh.

    abstract：INTRODUCTION:Live-attenuated influenza vaccines (LAIVs) have the potential to be affordable, effective, and logistically feasible for immunization of children in low-resource settings. MATERIAL AND METHODS:We conducted a phase II, randomized, double-blind, parallel group, placebo-controlled trial on the safety of the ...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2015.04.048

    authors： Ortiz JR,Goswami D,Lewis KD,Sharmeen AT,Ahmed M,Rahman M,Rahman MZ,Feser J,Neuzil KM,Brooks WA

    更新日期：2015-06-26 00:00:00

  • A recombinant vaccinia-rabies virus in the immunocompromised host: oral innocuity, progressive parenteral infection, and therapeutics.

    abstract：:With the emergence of raccoons (Procyon lotor) as the primary rabies reservoir in the United States of America, a recombinant vaccinia-rabies glycoprotein (V-RG) virus vaccine was developed that protected raccoons by the oral route from rabies infection. Despite extensive laboratory evaluation, vaccine safety concerns...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00163-6

    authors： Hanlon CA,Niezgoda M,Shankar V,Niu HS,Koprowski H,Rupprecht CE

    更新日期：1997-02-01 00:00:00

  • Factors underlying suboptimal childhood immunisation.

    abstract：:This review considers possible reasons behind parents' missed vaccination opportunities in the context of the latest immunisation coverage rates for England. Suboptimal uptake is not exclusive to measles, mumps and rubella (MMR). A substantial proportion of children also miss diphtheria, tetanus and polio vaccination....

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2006.06.060

    authors： Tickner S,Leman PJ,Woodcock A

    更新日期：2006-11-30 00:00:00

  • Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo.

    abstract：:The adenylate cyclase (CyaA) produced by Bordetella pertussis is able to deliver CD8+ and CD4+ T-cell epitopes genetically grafted within the catalytic domain of the molecule into antigen presenting cells in vivo. We develop now a new approach in which peptides containing CD8+ epitopes are chemically linked to CyaA. W...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.07.018

    authors： Fayolle C,Bauche C,Ladant D,Leclerc C

    更新日期：2004-12-16 00:00:00

  • The FAI protein of group C streptococci targets B-cells and exhibits adjuvant activity.

    abstract：:We have demonstrated that the fibrinogen-albumin-IgG receptor of group C streptococci (FAI) targets B-cells in vivo. We exploited the targeting properties of FAI to improve the immune responses stimulated by soluble antigens administered by the mucosal route. Enhanced systemic and mucosal immune responses were observe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.08.045

    authors： Schulze K,Goldmann O,Toppel A,Medina E,Guzmán CA

    更新日期：2005-02-03 00:00:00