Abstract：
:The adenylate cyclase (CyaA) produced by Bordetella pertussis is able to deliver CD8+ and CD4+ T-cell epitopes genetically grafted within the catalytic domain of the molecule into antigen presenting cells in vivo. We develop now a new approach in which peptides containing CD8+ epitopes are chemically linked to CyaA. We show that CTL responses were induced in mice immunized with CyaA bearing these CD8+ epitopes. Moreover, we demonstrate that the OVA257-264 CD8+ epitope chemically grafted to CyaA is presented to CD8+ T cells by a mechanism requiring (1) proteasome processing, (2) TAP and (3) neosynthesis of MHC class I molecules. Thus, this novel strategy represents a very versatile system as a single CyaA carrier protein could be easily and rapidly coupled to any desired synthetic peptide.
journal_name
Vaccinejournal_title
Vaccineauthors
Fayolle C,Bauche C,Ladant D,Leclerc Cdoi
10.1016/j.vaccine.2004.07.018subject
Has Abstractpub_date
2004-12-16 00:00:00pages
604-14issue
5eissn
0264-410Xissn
1873-2518pii
S0264-410X(04)00537-7journal_volume
23pub_type
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