Abstract:
:A recombinant Lactobacillus casei expressing a flagellar antigen from Salmonella enterica serovar Enteritidis was constructed and evaluated as a mucosal vaccine. Intragastric immunization of the recombinant strain conferred protective immunity against Salmonella infection in mice. This immunization did not result in antigen-specific antibody in either feces or sera but induced the release of IFN-gamma on restimulation of primed lymphocytes ex vivo. The results suggested that the protective efficacy provided by flagellin-expressing L. casei is mainly attributable to cell-mediated immune responses. In addition, an adjuvant-type effect of the antigen delivery system with L. casei was also observed.
journal_name
Vaccinejournal_title
Vaccineauthors
Kajikawa A,Satoh E,Leer RJ,Yamamoto S,Igimi Sdoi
10.1016/j.vaccine.2007.01.055subject
Has Abstractpub_date
2007-05-04 00:00:00pages
3599-605issue
18eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00083-7journal_volume
25pub_type
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