Protection induced in mice against a lethal orthopox virus by the Lister strain of vaccinia virus and modified vaccinia virus Ankara (MVA).


:The Lister (Elstree) strain of vaccinia virus, used in Israel for vaccination against smallpox, was studied in tissue cultures and in a mouse model. The virus failed to reach the brain of the mice when inoculated intranasally at a dose of 500,000 plaque forming units, but was lethal for 50% of them, when injected intracranially. Lower doses of virus injected intracranially caused some weight loss initially, but later the mice completely recovered. Modified vaccinia virus Ankara (MVA), when infected intranasally, did not spread beyond the lungs to other organs of the mice. Even when the mice were inoculated with MVA intracranially, they were not affected. Significant protection against a lethal dose of an orthopoxvirus was obtained in mice following immunization with the Lister strain, while larger doses and repeated vaccination procedure, were required with MVA. The Lister virus stock applied in Israel, was found to be heterogeneous in its plaque morphology. Two variants isolated from it, showed significant attenuation for mice, when inoculated intranasally and intracranially, as compared to a third variant and to the unpurified stock of the virus.






Abdalrhman I,Gurt I,Katz E




Has Abstract


2006-05-08 00:00:00
















  • Immunogenicity and safety of the inactivated poliomyelitis vaccine made from Sabin strains in a phase IV clinical trial for the vaccination of a large population.

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    authors: Jiang R,Liu X,Sun X,Wang J,Huang Z,Li C,Li Z,Zhou J,Pu Y,Ying Z,Yin Q,Zhao Z,Zhang L,Lei J,Bao W,Jiang Y,Dou Y,Li J,Yang H,Cai W,Deng Y,Che Y,Shi L,Sun M

    更新日期:2021-01-21 00:00:00

  • South Asia symposium on pneumococcal disease and the promise of vaccines - Meeting report.

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    pub_type: 杂志文章


    authors: Kumar R,Arora N,Santosham M

    更新日期:2016-05-17 00:00:00

  • Influenza vaccination coverage among adults with diabetes, United States, 2007-08 through 2017-18 seasons.

    abstract:BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...


    pub_type: 杂志文章


    authors: Hung MC,Lu PJ,Srivastav A,Cheng YJ,Williams WW

    更新日期:2020-09-29 00:00:00

  • Cost-effectiveness of mass dog rabies vaccination strategies to reduce human health burden in Flores Island, Indonesia.

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    authors: Wera E,Mourits MCM,Hogeveen H

    更新日期:2017-12-04 00:00:00

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    pub_type: 杂志文章


    authors: Wahren E,Bengtsson C,Björkstén B,Mark A,Granström M

    更新日期:1998-05-01 00:00:00

  • Comparative immunogenicity in children of mammalian cell-derived recombinant hepatitis B vaccine and plasma-derived hepatitis B vaccine.

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    pub_type: 杂志文章


    authors: Coursaget P,Bringer L,Sarr G,Bourdil C,Fritzell B,Blondeau C,Yvonnet B,Chiron JP,Jeannée E,Guindo S

    更新日期:1992-01-01 00:00:00

  • Vaccination with a gE-negative bovine herpesvirus type 1 vaccine confers insufficient protection to a bovine herpesvirus type 5 challenge.

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    pub_type: 杂志文章


    authors: Silva AD,Spilki FR,Franco AC,Esteves PA,Hübner SO,Driemeier D,Oliveira AP,Rijsewijk F,Roehe PM

    更新日期:2006-04-12 00:00:00

  • Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA.

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    authors: Pertmer TM,Eisenbraun MD,McCabe D,Prayaga SK,Fuller DH,Haynes JR

    更新日期:1995-01-01 00:00:00

  • Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles.

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    pub_type: 杂志文章


    authors: Kumar R,Ray PC,Datta D,Bansal GP,Angov E,Kumar N

    更新日期:2015-09-22 00:00:00

  • Mucosal immunization with a replication-deficient adenovirus vector expressing murine cytomegalovirus glycoprotein B induces mucosal and systemic immunity.

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    authors: Shanley JD,Wu CA

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  • The feasibility of identifying children with primary immunodeficiency disorders: preparation for the polio post-eradication era in Bangladesh.

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    pub_type: 杂志文章


    authors: Sazzad HM,Rainey JJ,Mach O,Sutter R,Diordista S,Kawser CA,Mobarak R,Alam D,Chowdhury MA,Hossain MJ,Hasan AS,Luby SP

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    pub_type: 杂志文章


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  • Recombinant hemagglutinin protein of rinderpest virus expressed in insect cells induces humoral and cell mediated immune responses in cattle.

    abstract::Rinderpest virus causes a highly contagious and often fatal disease in domestic and wild ruminants. The surface glycoproteins, hemagglutinin (H) and fusion (F) proteins of this enveloped virus are known to confer protective immunity in cattle. We have reported the generation of a recombinant baculovirus expressing H p...


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    authors: Sinnathamby G,Naik S,Renukaradhya GJ,Rajasekhar M,Nayak R,Shaila MS

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  • Use of mobile phones for improving vaccination coverage among children living in rural hard-to-reach areas and urban streets of Bangladesh.

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    pub_type: 杂志文章


    authors: Uddin MJ,Shamsuzzaman M,Horng L,Labrique A,Vasudevan L,Zeller K,Chowdhury M,Larson CP,Bishai D,Alam N

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    authors: Siddiqui AA,Pinkston JR,Quinlin ML,Saeed Q,White GL,Shearer MH,Kennedy RC

    更新日期:2005-02-10 00:00:00

  • Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system.

    abstract::An enzymatically cleaved glycoprotein fragment (amino acids 28-328: 40 kDa) from influenza virus haemagglutinin (TOPS) was used to assess an intravaginal antigen delivery system, comprising lysophosphatidylcholine (LPC) and degradable starch microspheres (DSM). Three groups of three sheep received intravaginal immuniz...


    pub_type: 杂志文章


    authors: O'Hagan DT,Rafferty D,Wharton S,Illum L

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  • E-health use, vaccination knowledge and perception of own risk: drivers of vaccination uptake in medical students.

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    pub_type: 杂志文章


    authors: Betsch C,Wicker S

    更新日期:2012-02-01 00:00:00

  • Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop.

    abstract::Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing ...


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    authors: Moreland NJ,Waddington CS,Williamson DA,Sriskandan S,Smeesters PR,Proft T,Steer AC,Walker MJ,Baker EN,Baker MG,Lennon D,Dunbar R,Carapetis J,Fraser JD

    更新日期:2014-06-24 00:00:00

  • Parent "cocoon" immunization to prevent pertussis-related hospitalization in infants: the case of Piemonte in Italy.

    abstract::Pertussis incidence in Piemonte (Italy) is now at the lowest level ever reached (0.85 per 100,000 in 2010) but the disease is still endemic in infants (54 per 100,000 in 2005-2010). Parental "cocoon" immunization has been proposed in some countries (i.e. United States, France) as a measure to protect newborns from ser...


    pub_type: 杂志文章


    authors: Meregaglia M,Ferrara L,Melegaro A,Demicheli V

    更新日期:2013-02-06 00:00:00

  • Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate.

    abstract::A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...


    pub_type: 杂志文章,评审


    authors: Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii T

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  • Characterisation of the antibody response to a totally synthetic immunocontraceptive peptide vaccine based on LHRH.

    abstract::In this study we describe our attempts to improve the immunogenicity of a synthetic epitope-based vaccine. The vaccine consists of an epitope (P25) that is recognised by CD4+ helper T cells and the target epitope luteinising hormone releasing hormone (LHRH). We show that replacement of the single cysteine residue with...


    pub_type: 杂志文章


    authors: Zeng W,Gauci S,Ghosh S,Walker J,Jackson DC

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  • Cost of plasma-derived hepatitis B vaccine production.

    abstract::It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...


    pub_type: 杂志文章


    authors: Mahoney RT

    更新日期:1990-08-01 00:00:00

  • The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies.

    abstract::Respiratory syncytial virus (RSV) causes severe respiratory illness in infants. There are no licensed vaccines to prevent RSV infection. The neonate receives short-term protection from maternally derived antibodies, which, however, can also interfere with the active response to vaccination. A RSV vaccine consisting of...


    pub_type: 杂志文章


    authors: Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

    更新日期:2015-03-10 00:00:00

  • A national examination of pharmacy-based immunization statutes and their association with influenza vaccinations and preventive health.

    abstract:BACKGROUND:A series of state-level statute changes have allowed pharmacists to provide influenza vaccinations in community pharmacies. The study aim was to estimate the effects of pharmacy-based immunization statutes changes on per capita influenza vaccine prescriptions, adult vaccination rates, and the utilization of ...


    pub_type: 杂志文章


    authors: McConeghy KW,Wing C

    更新日期:2016-06-24 00:00:00

  • Risk factors for pertussis hospitalizations in Australians aged 45 years and over: A population based nested case-control study.

    abstract::Although studies have described factors associated with pertussis hospitalization in children, data on adult hospitalization are sparse. We examined the association between patient characteristics and hospitalization among older adults with pertussis. We conducted a nested case-control study of participants in the 45 ...


    pub_type: 杂志文章


    authors: Karki S,McIntyre P,Newall AT,MacIntyre CR,Banks E,Liu B

    更新日期:2015-10-13 00:00:00

  • AIDS and HIV vaccines.

    abstract::In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite...


    pub_type: 杂志文章,评审


    authors: Klein M

    更新日期:1999-10-01 00:00:00

  • Expression of HIV-1 envelope gene by recombinant avipox viruses.

    abstract::Recombinant canarypox (CP) and fowlpox (FP) viruses that contained two forms of the HIV-1 (SF2 strain) env gene were engineered and their expression analysed in chick, simian and human cells. These vectors can efficiently replicate in avian but not in mammalian cells, in which infection is abortive. The two forms, con...


    pub_type: 杂志文章


    authors: Radaelli A,De Giuli Morghen C

    更新日期:1994-09-01 00:00:00

  • Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain.

    abstract::The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(O...


    pub_type: 杂志文章


    authors: Zhang CH,Lu JH,Wang YF,Zheng HY,Xiong S,Zhang MY,Liu XJ,Li JX,Wan ZY,Yan XG,Qi SY,Cui Z,Zhang B

    更新日期:2005-05-02 00:00:00

  • Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...


    pub_type: 杂志文章


    authors: Amani J,Salmanian AH,Rafati S,Mousavi SL

    更新日期:2010-10-04 00:00:00

  • The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4+ T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway.

    abstract::Vaccination remains the most cost-effective biomedical approach for controlling influenza disease. In times of pandemics, however, these vaccines cannot be produced in sufficient quantities for worldwide use by the current manufacturing capacities and practices. What is needed is the development of adjuvanted vaccines...


    pub_type: 杂志文章


    authors: Jain S,George PJ,Deng W,Koussa J,Parkhouse K,Hensley SE,Jiang J,Lu J,Liu Z,Wei J,Zhan B,Bottazzi ME,Shen H,Lustigman S

    更新日期:2018-06-14 00:00:00