Protection induced in mice against a lethal orthopox virus by the Lister strain of vaccinia virus and modified vaccinia virus Ankara (MVA).

Abstract:

:The Lister (Elstree) strain of vaccinia virus, used in Israel for vaccination against smallpox, was studied in tissue cultures and in a mouse model. The virus failed to reach the brain of the mice when inoculated intranasally at a dose of 500,000 plaque forming units, but was lethal for 50% of them, when injected intracranially. Lower doses of virus injected intracranially caused some weight loss initially, but later the mice completely recovered. Modified vaccinia virus Ankara (MVA), when infected intranasally, did not spread beyond the lungs to other organs of the mice. Even when the mice were inoculated with MVA intracranially, they were not affected. Significant protection against a lethal dose of an orthopoxvirus was obtained in mice following immunization with the Lister strain, while larger doses and repeated vaccination procedure, were required with MVA. The Lister virus stock applied in Israel, was found to be heterogeneous in its plaque morphology. Two variants isolated from it, showed significant attenuation for mice, when inoculated intranasally and intracranially, as compared to a third variant and to the unpurified stock of the virus.

journal_name

Vaccine

journal_title

Vaccine

authors

Abdalrhman I,Gurt I,Katz E

doi

10.1016/j.vaccine.2006.02.012

subject

Has Abstract

pub_date

2006-05-08 00:00:00

pages

4152-60

issue

19

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00167-8

journal_volume

24

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Immunogenicity and safety of the inactivated poliomyelitis vaccine made from Sabin strains in a phase IV clinical trial for the vaccination of a large population.

    abstract::As a recently launched novel vaccine used as one of the vaccines for the final eradication of polios worldwide, complete data on the consistency and immunogenicity characteristics of the inactivated poliomyelitis vaccine made from the Sabin strain (sIPV) and its safety in large-scale populations are required to suppor...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2021.01.027

    authors: Jiang R,Liu X,Sun X,Wang J,Huang Z,Li C,Li Z,Zhou J,Pu Y,Ying Z,Yin Q,Zhao Z,Zhang L,Lei J,Bao W,Jiang Y,Dou Y,Li J,Yang H,Cai W,Deng Y,Che Y,Shi L,Sun M

    更新日期:2021-01-21 00:00:00

  • South Asia symposium on pneumococcal disease and the promise of vaccines - Meeting report.

    abstract::Despite the licensure of the pneumococcal conjugate vaccine (PCV) in the US and other Western countries for over 14 years, as of September 2014 only 4 South Asian countries were using PCV in their universal immunization program. To generate momentum toward addressing this issue a "South Asia symposium on pneumococcal ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.03.071

    authors: Kumar R,Arora N,Santosham M

    更新日期:2016-05-17 00:00:00

  • Influenza vaccination coverage among adults with diabetes, United States, 2007-08 through 2017-18 seasons.

    abstract:BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2020.08.008

    authors: Hung MC,Lu PJ,Srivastav A,Cheng YJ,Williams WW

    更新日期:2020-09-29 00:00:00

  • Cost-effectiveness of mass dog rabies vaccination strategies to reduce human health burden in Flores Island, Indonesia.

    abstract::The cost-effectiveness of different mass dog rabies vaccination strategies, defined as the costs per year of life lost (YLL) averted was evaluated for a period of 10 years by means of a dynamic simulation study for a typical village on Flores Island. In the base strategy (no dog vaccination and no post-exposure treatm...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.10.009

    authors: Wera E,Mourits MCM,Hogeveen H

    更新日期:2017-12-04 00:00:00

  • Capture EIA for determination of IgE to diphtheria and tetanus toxins in comparison to RIA.

    abstract::A capture IgE assay in EIA with diphtheria toxin and tetanus toxoid as model systems was developed and evaluated in relation to RIA in a DT booster study. The EIA and the RIA gave very similar results, although the EIA determined IgE over a wider range of concentrations, without interference by other subclasses. The c...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(97)00274-0

    authors: Wahren E,Bengtsson C,Björkstén B,Mark A,Granström M

    更新日期:1998-05-01 00:00:00

  • Comparative immunogenicity in children of mammalian cell-derived recombinant hepatitis B vaccine and plasma-derived hepatitis B vaccine.

    abstract::Three doses of hepatitis B vaccine were given at 2, 4 and 9 months of age to 220 Senegalese infants living in the Dakar area of Senegal. Half of the infants received 5 micrograms plasma-derived hepatitis B vaccine (Hevac B) and the remainder 20 micrograms mammalian cell-derived recombinant hepatitis B vaccine (GenHeva...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(92)90067-t

    authors: Coursaget P,Bringer L,Sarr G,Bourdil C,Fritzell B,Blondeau C,Yvonnet B,Chiron JP,Jeannée E,Guindo S

    更新日期:1992-01-01 00:00:00

  • Vaccination with a gE-negative bovine herpesvirus type 1 vaccine confers insufficient protection to a bovine herpesvirus type 5 challenge.

    abstract::In the present study, cross-protection to bovine herpesvirus type 5 (BHV-5) induced by bovine herpesvirus type 1 (BHV-1) vaccination was examined following inoculation of rabbits and calves with a glycoprotein E (gE)-negative BHV-1 vaccine and subsequent challenge with BHV-5. Rabbits (n=5) and calves (n=8) were vaccin...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2006.01.024

    authors: Silva AD,Spilki FR,Franco AC,Esteves PA,Hübner SO,Driemeier D,Oliveira AP,Rijsewijk F,Roehe PM

    更新日期:2006-04-12 00:00:00

  • Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA.

    abstract::Particle-mediated (gene gun) DNA transfer to the epidermis was evaluated for its ability to elicit humoral and cytotoxic T lymphocyte responses using decreasing quantities of plasmid DNA-based antigen expression vectors. Using plasmids encoding human growth hormone, human alpha-1-antitrypsin, and influenza virus nucle...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(95)00069-d

    authors: Pertmer TM,Eisenbraun MD,McCabe D,Prayaga SK,Fuller DH,Haynes JR

    更新日期:1995-01-01 00:00:00

  • Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles.

    abstract::Malaria transmission-blocking vaccines (TBV) targeting sexual stages of the parasite represent an ideal intervention to reduce the burden of the disease and eventual elimination at the population level in endemic regions. Immune responses against sexual stage antigens impair the development of parasite inside the mosq...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.08.025

    authors: Kumar R,Ray PC,Datta D,Bansal GP,Angov E,Kumar N

    更新日期:2015-09-22 00:00:00

  • Mucosal immunization with a replication-deficient adenovirus vector expressing murine cytomegalovirus glycoprotein B induces mucosal and systemic immunity.

    abstract::The murine cytomegalovirus (MCMV) glycoprotein B (gB) gene was expressed in an adenovirus replication-deficient vector. This virus, designated Ad-gB, was used to immunize BALB/c and B6 mice by the intranasal (i.n.) route to induce an immune response. Following primary immunization, antibody was detected in serum of 10...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(03)00037-9

    authors: Shanley JD,Wu CA

    更新日期:2003-06-02 00:00:00

  • The feasibility of identifying children with primary immunodeficiency disorders: preparation for the polio post-eradication era in Bangladesh.

    abstract:BACKGROUND:Persons with primary immunodeficiency disorders (PIDD) who receive oral poliovirus vaccine (OPV) or are household contacts of OPV recipients are at risk of excreting immunodeficiency-associated vaccine-derived polioviruses (iVDPVs). iVDPVs can be transmitted and cause paralytic polio. The objective of this s...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.06.017

    authors: Sazzad HM,Rainey JJ,Mach O,Sutter R,Diordista S,Kawser CA,Mobarak R,Alam D,Chowdhury MA,Hossain MJ,Hasan AS,Luby SP

    更新日期:2012-08-03 00:00:00

  • Effects of imperfect test sensitivity and specificity on observational studies of influenza vaccine effectiveness.

    abstract:BACKGROUND:The recently developed test-negative design is now standard for observational studies of influenza vaccine effectiveness (VE). It is unclear how influenza test misclassification biases test-negative VE estimates relative to VE estimates from traditional cohort or case-control studies. METHODS:We simulated p...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.01.069

    authors: Jackson ML,Rothman KJ

    更新日期:2015-03-10 00:00:00

  • Recombinant hemagglutinin protein of rinderpest virus expressed in insect cells induces humoral and cell mediated immune responses in cattle.

    abstract::Rinderpest virus causes a highly contagious and often fatal disease in domestic and wild ruminants. The surface glycoproteins, hemagglutinin (H) and fusion (F) proteins of this enveloped virus are known to confer protective immunity in cattle. We have reported the generation of a recombinant baculovirus expressing H p...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(01)00127-x

    authors: Sinnathamby G,Naik S,Renukaradhya GJ,Rajasekhar M,Nayak R,Shaila MS

    更新日期:2001-07-16 00:00:00

  • Use of mobile phones for improving vaccination coverage among children living in rural hard-to-reach areas and urban streets of Bangladesh.

    abstract::In Bangladesh, full vaccination rates among children living in rural hard-to-reach areas and urban streets are low. We conducted a quasi-experimental pre-post study of a 12-month mobile phone intervention to improve vaccination among 0-11 months old children in rural hard-to-reach and urban street dweller areas. Softw...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.11.024

    authors: Uddin MJ,Shamsuzzaman M,Horng L,Labrique A,Vasudevan L,Zeller K,Chowdhury M,Larson CP,Bishai D,Alam N

    更新日期:2016-01-04 00:00:00

  • Characterization of the immune response to DNA vaccination strategies for schistosomiasis candidate antigen, Sm-p80 in the baboon.

    abstract::Even though schistosomicidal agents and other control measures, including public hygiene and snail control exist, development of an efficacious vaccine still remains the most potentially powerful method for control of schistosomiasis. In our continuing efforts to develop a vaccine against schistosomiasis, we have sele...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2004.09.018

    authors: Siddiqui AA,Pinkston JR,Quinlin ML,Saeed Q,White GL,Shearer MH,Kennedy RC

    更新日期:2005-02-10 00:00:00

  • Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system.

    abstract::An enzymatically cleaved glycoprotein fragment (amino acids 28-328: 40 kDa) from influenza virus haemagglutinin (TOPS) was used to assess an intravaginal antigen delivery system, comprising lysophosphatidylcholine (LPC) and degradable starch microspheres (DSM). Three groups of three sheep received intravaginal immuniz...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(93)90313-m

    authors: O'Hagan DT,Rafferty D,Wharton S,Illum L

    更新日期:1993-01-01 00:00:00

  • E-health use, vaccination knowledge and perception of own risk: drivers of vaccination uptake in medical students.

    abstract:OBJECTIVE:was to improve understanding of mechanisms contributing to healthcare personnel's (HCP) reluctance to get vaccinated against seasonal influenza. We assessed the role of several drivers: vaccination knowledge, vaccination recommendations and the role of the Internet (so-called e-health) in creating vaccination...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.12.021

    authors: Betsch C,Wicker S

    更新日期:2012-02-01 00:00:00

  • Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop.

    abstract::Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.05.017

    authors: Moreland NJ,Waddington CS,Williamson DA,Sriskandan S,Smeesters PR,Proft T,Steer AC,Walker MJ,Baker EN,Baker MG,Lennon D,Dunbar R,Carapetis J,Fraser JD

    更新日期:2014-06-24 00:00:00

  • Parent "cocoon" immunization to prevent pertussis-related hospitalization in infants: the case of Piemonte in Italy.

    abstract::Pertussis incidence in Piemonte (Italy) is now at the lowest level ever reached (0.85 per 100,000 in 2010) but the disease is still endemic in infants (54 per 100,000 in 2005-2010). Parental "cocoon" immunization has been proposed in some countries (i.e. United States, France) as a measure to protect newborns from ser...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.12.061

    authors: Meregaglia M,Ferrara L,Melegaro A,Demicheli V

    更新日期:2013-02-06 00:00:00

  • Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate.

    abstract::A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/j.vaccine.2011.06.052

    authors: Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii T

    更新日期:2011-08-11 00:00:00

  • Characterisation of the antibody response to a totally synthetic immunocontraceptive peptide vaccine based on LHRH.

    abstract::In this study we describe our attempts to improve the immunogenicity of a synthetic epitope-based vaccine. The vaccine consists of an epitope (P25) that is recognised by CD4+ helper T cells and the target epitope luteinising hormone releasing hormone (LHRH). We show that replacement of the single cysteine residue with...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2005.04.015

    authors: Zeng W,Gauci S,Ghosh S,Walker J,Jackson DC

    更新日期:2005-08-15 00:00:00

  • Cost of plasma-derived hepatitis B vaccine production.

    abstract::It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(90)90101-q

    authors: Mahoney RT

    更新日期:1990-08-01 00:00:00

  • The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies.

    abstract::Respiratory syncytial virus (RSV) causes severe respiratory illness in infants. There are no licensed vaccines to prevent RSV infection. The neonate receives short-term protection from maternally derived antibodies, which, however, can also interfere with the active response to vaccination. A RSV vaccine consisting of...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.01.041

    authors: Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

    更新日期:2015-03-10 00:00:00

  • A national examination of pharmacy-based immunization statutes and their association with influenza vaccinations and preventive health.

    abstract:BACKGROUND:A series of state-level statute changes have allowed pharmacists to provide influenza vaccinations in community pharmacies. The study aim was to estimate the effects of pharmacy-based immunization statutes changes on per capita influenza vaccine prescriptions, adult vaccination rates, and the utilization of ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.04.076

    authors: McConeghy KW,Wing C

    更新日期:2016-06-24 00:00:00

  • Risk factors for pertussis hospitalizations in Australians aged 45 years and over: A population based nested case-control study.

    abstract::Although studies have described factors associated with pertussis hospitalization in children, data on adult hospitalization are sparse. We examined the association between patient characteristics and hospitalization among older adults with pertussis. We conducted a nested case-control study of participants in the 45 ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.08.068

    authors: Karki S,McIntyre P,Newall AT,MacIntyre CR,Banks E,Liu B

    更新日期:2015-10-13 00:00:00

  • AIDS and HIV vaccines.

    abstract::In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/s0264-410x(99)00236-4

    authors: Klein M

    更新日期:1999-10-01 00:00:00

  • Expression of HIV-1 envelope gene by recombinant avipox viruses.

    abstract::Recombinant canarypox (CP) and fowlpox (FP) viruses that contained two forms of the HIV-1 (SF2 strain) env gene were engineered and their expression analysed in chick, simian and human cells. These vectors can efficiently replicate in avian but not in mammalian cells, in which infection is abortive. The two forms, con...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(94)90180-5

    authors: Radaelli A,De Giuli Morghen C

    更新日期:1994-09-01 00:00:00

  • Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain.

    abstract::The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(O...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2004.11.073

    authors: Zhang CH,Lu JH,Wang YF,Zheng HY,Xiong S,Zhang MY,Liu XJ,Li JX,Wan ZY,Yan XG,Qi SY,Cui Z,Zhang B

    更新日期:2005-05-02 00:00:00

  • Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.07.061

    authors: Amani J,Salmanian AH,Rafati S,Mousavi SL

    更新日期:2010-10-04 00:00:00

  • The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4+ T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway.

    abstract::Vaccination remains the most cost-effective biomedical approach for controlling influenza disease. In times of pandemics, however, these vaccines cannot be produced in sufficient quantities for worldwide use by the current manufacturing capacities and practices. What is needed is the development of adjuvanted vaccines...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2018.05.029

    authors: Jain S,George PJ,Deng W,Koussa J,Parkhouse K,Hensley SE,Jiang J,Lu J,Liu Z,Wei J,Zhan B,Bottazzi ME,Shen H,Lustigman S

    更新日期:2018-06-14 00:00:00