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Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial.

Abstract：

:HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Deloria-Knoll M,Steinhoff M,Semba RD,Nelson K,Vlahov D,Meinert CL

doi

10.1016/j.vaccine.2005.09.047

subject

Has Abstract

pub_date

2006-03-06 00:00:00

pages

1670-9

issue

10

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)01013-3

journal_volume

24

pub_type

杂志文章,随机对照试验

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