Abstract:
:HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Deloria-Knoll M,Steinhoff M,Semba RD,Nelson K,Vlahov D,Meinert CLdoi
10.1016/j.vaccine.2005.09.047subject
Has Abstractpub_date
2006-03-06 00:00:00pages
1670-9issue
10eissn
0264-410Xissn
1873-2518pii
S0264-410X(05)01013-3journal_volume
24pub_type
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