Combined DNA vaccine encapsulated in microspheres enhanced protection efficacy against Mycobacterium tuberculosis infection of mice.

abstract：:Influenza B virus infections are mainly restricted to humans, which is partially caused by the inability of influenza B virus NS1 protein to counteract the innate immune response of other species. However, for cell culture-based influenza vaccine production non-human cells, such as Madin-Darby canine kidney (MDCK) cel...

journal_title：Vaccine

authors： Frensing T,Seitz C,Heynisch B,Patzina C,Kochs G,Reichl U

更新日期：2011-09-22 00:00:00

abstract：:Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. We have previously reported the construction and characterization of a single gene apxIIC deletion mutant HB04C(-) based on A. pleuropneumoniae serovar 7 which produces ApxII toxin and ApxIV....

journal_title：Vaccine

authors： Liu J,Chen X,Lin L,Tan C,Chen Y,Guo Y,Jin M,Guo A,Bei W,Chen H

更新日期：2007-11-01 00:00:00

abstract：:Clinical leprosy is characterized by varying manifestations between tuberculoid and lepromatous leprosy. In the former state the patient is able to elicit a cell-mediated immune response whereas in the latter, there is usually a humoral response. An understanding of this immunological balance is crucial in the search ...

journal_title：Vaccine

authors： Stewart-Tull DE

更新日期：1984-12-01 00:00:00

abstract：:We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 ...

journal_title：Vaccine

authors： Halperin SA,Scheifele D,Mills E,Guasparini R,Humphreys G,Barreto L,Smith B

更新日期：2003-06-02 00:00:00

abstract：:The effects of beta-propiolactone (BPL), an alkylating and virus inactivating agent, on the structural and in vitro biological properties of different DNA preparations from BHK-21 cells were investigated. Both uninfected and rabies virus-infected cells were used. Purified cellular DNA (celDNA) was used as the referenc...

journal_title：Vaccine

authors： Morgeaux S,Tordo N,Gontier C,Perrin P

更新日期：1993-01-01 00:00:00

abstract：:The aim of the study was to compare the responses of homosexual men (HM) receiving a standard course of recombinant hepatitis B vaccine with those of healthcare workers vaccinated in the same hospital over the same period. Boosters for inadequate responders and repeat courses for non-responders were given. Forty of 61...

journal_title：Vaccine

authors： Das S,Brassington M,Drake SM,Boxall E

更新日期：2003-09-08 00:00:00

abstract：:Liposome and cholera toxin (CT) are considered to be effective antigen delivery vehicles and adjuvants for mucosal vaccines. The effect of these antigen delivery systems on adjuvant responses to mucosally administered pneumococcal polysaccharide (Pnup) was investigated in this study. Both mucosal (e.g. oral) and syste...

journal_title：Vaccine

authors： VanCott JL,Kobayashi T,Yamamoto M,Pillai S,McGhee JR,Kiyono H

更新日期：1996-04-01 00:00:00

abstract：:The immunogenic potential of Vibrio cholerae ghosts (VCG) in comparison with heat-killed whole-cell vibrios (WCV) was evaluated after intraperitoneal immunization of adult mice. Swiss white mice received four doses of VCG or WCV intraperitoneally, consisting of 500 micrograms of lyophilized material in 200 microliters...

journal_title：Vaccine

authors： Eko FO,Hensel A,Bunka S,Lubitz W

更新日期：1994-11-01 00:00:00

abstract：:Behcet's disease (BD) is a chronic, recurrent, inflammatory, multisystemic disorder characterized primarily by vasculitis. The etiopathogenesis of BD involves immunogenetics, infectious organisms (streptococcus, herpes simplex virus), immunoregulation and vascular dysfunctions. We previously found that immunoregulatio...

journal_title：Vaccine

authors： Lee SI,Kwon HJ,Lee ES,Yang BC,Bang D,Lee S,Sohn S

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:Adverse events following immunization (AEFI) requires special consideration in patients with primary immunodeficiency diseases (PID) because they may represent a "red flag" for the initial diagnosis and may cause disease complications. Therefore, the definition of appropriate vaccination schemes is a major i...

journal_title：Vaccine

authors： Sarmiento JD,Villada F,Orrego JC,Franco JL,Trujillo-Vargas CM

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability. Fishermen, while taking the first vaccine dose under supervision, received the second dose in a sealed bag, and were...

journal_title：Vaccine

authors： Grandesso F,Kasambara W,Page AL,Debes AK,M'bang'ombe M,Palomares A,Lechevalier P,Pezzoli L,Alley I,Salumu L,Msyamboza K,Sack D,Cohuet S,Luquero FJ

更新日期：2019-06-19 00:00:00

abstract：:Recently, efforts have been made to fill a so-called "vaccine gap" between Japan and other countries; however, more work remains. Concerns about adverse events following immunization (AEFI) resulted in an historically passive approach to policy making in the National Immunization Program (NIP). For example, reports of...

journal_title：Vaccine

authors： Katsuta T,Moser CA,Feemster KA,Saitoh A,Offit PA

更新日期：2020-10-27 00:00:00

abstract：INTRODUCTION:Annual influenza vaccine coverage for young adults (including college students) remains low, despite a 2011 US recommendation for annual immunization of all people 6 months and older. College students are at high risk for influenza morbidity given close living and social spaces and extended travel during s...

journal_title：Vaccine

authors： Bednarczyk RA,Chu SL,Sickler H,Shaw J,Nadeau JA,McNutt LA

更新日期：2015-03-30 00:00:00

abstract：:DNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to genera...

journal_title：Vaccine

authors： Tang CK,Sheng KC,Pouniotis D,Esparon S,Son HY,Kim CW,Pietersz GA,Apostolopoulos V

更新日期：2008-07-23 00:00:00

abstract：:Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular pertussis antigens (DTaP) at 2, 4 and 6 months of age. Interest is growing in the possibility that vaccination at birth might provide earlier protection of infants, b...

journal_title：Vaccine

authors： White OJ,Rowe J,Richmond P,Marshall H,McIntyre P,Wood N,Holt PG

更新日期：2010-03-19 00:00:00

abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

journal_title：Vaccine

authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid benefit-risk (B/R) monitoring of vaccines using European healthcare databases. Event misclassification can result in biased estimates. Using di...

journal_title：Vaccine

authors： Gini R,Dodd CN,Bollaerts K,Bartolini C,Roberto G,Huerta-Alvarez C,Martín-Merino E,Duarte-Salles T,Picelli G,Tramontan L,Danieli G,Correa A,McGee C,Becker BFH,Switzer C,Gandhi-Banga S,Bauwens J,van der Maas NAT,Spiteri

更新日期：2020-12-22 00:00:00

abstract：OBJECTIVES:To perform a systematic review of all serious adverse events (SAEs) after yellow fever vaccination and to assess them according to Brighton Collaboration criteria. METHODS:Nine electronic databases were searched with the terms "yellow fever vaccine" and "adverse events" to 10 July 2013 (no language/date lim...

journal_title：Vaccine

authors： Thomas RE,Spragins W,Lorenzetti DL

更新日期：2013-12-16 00:00:00

abstract：:In this study, the potential of N-Trimethyl chitosan (TMC, degree of quaternization 50%) and dextran microparticles for pulmonary delivery of diphtheria toxoid (DT) was investigated. The antigen-containing microparticles were prepared by drying of an aqueous solution of polymer and DT through a supercritical fluid (SC...

journal_title：Vaccine

authors： Amidi M,Pellikaan HC,Hirschberg H,de Boer AH,Crommelin DJ,Hennink WE,Kersten G,Jiskoot W

更新日期：2007-09-17 00:00:00

abstract：:Continuing investments in vaccine innovation are insufficiently translated into market entries of novel vaccines. This innovation paradox is in part caused by stakeholders lacking complete understanding of the complex array of steps necessary for vaccine development and collaboration difficulties between the wide vari...

journal_title：Vaccine

authors： Van de Burgwal LHM,Ribeiro CDS,Van der Waal MB,Claassen E

更新日期：2018-11-26 00:00:00

abstract：:DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutra...

journal_title：Vaccine

authors： Yang K,Mustafa F,Valsamakis A,Santoro JC,Griffin DE,Robinson HL

更新日期：1997-06-01 00:00:00

abstract：:Active and passive immunotherapy targeting amyloid-β (Aβ) may be the most promising strategy to prevent or treat Alzheimer's disease (AD). Previously, immunization with the recombinant 6Aβ15-T antigen generated robust anti-Aβ serum antibodies that strongly recognized Aβ42 oligomers in different mice, markedly reduced ...

journal_title：Vaccine

authors： Wang HC,Yu YZ,Liu S,Zhao M,Xu Q

更新日期：2016-04-04 00:00:00

abstract：:The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69...

journal_title：Vaccine

authors： Konno R,Konishi H,Sauvaget C,Ohashi Y,Kakizoe T

更新日期：2018-12-18 00:00:00

abstract：:Understanding the mechanisms of generation and maintenance of immunological memory is crucial for rational vaccine design. A hypothesis known as relay hypothesis was earlier proposed which explains the maintenance of immunological memory through interaction of idiotypic and anti-idiotypic lymphocytes. In the present s...

journal_title：Vaccine

authors： Vani J,Nayak R,Shaila MS

更新日期：2007-06-21 00:00:00

abstract：:HIV-1 Tat protein activates resting cells, rendering them permissive for viral replication. Replication of HIV-1 in vitro is enhanced by intercellular passage of Tat protein and inhibited by anti-Tat antibodies. Tat dependence of HIV-1 replication in vivo during acute, chronic asymptomatic and AIDS stages of infection...

journal_title：Vaccine

authors： Goldstein G,Manson K,Tribbick G,Smith R

更新日期：2000-06-15 00:00:00

abstract：:Extending the benefits of vaccination to everyone who is eligible requires an understanding of which populations current vaccination efforts have struggled to reach. A clear definition of "hard-to-reach" populations - also known as high-risk or marginalized populations, or reaching the last mile - is essential for est...

journal_title：Vaccine

authors： Ozawa S,Yemeke TT,Evans DR,Pallas SE,Wallace AS,Lee BY

更新日期：2019-09-03 00:00:00

abstract：:Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations w...

journal_title：Vaccine

authors： Nurkka A,MacLennan J,Jäntti V,Obaro S,Greenwood B,Käyhty H

更新日期：2000-10-15 00:00:00

abstract：:In this study, the impact of Th1-inducing cytokine gene co-delivery and antigen boosting on humoral and cellular responses induced by multiepitopic DNA immunization in mice have been investigated. Intramuscular injection of mixed DNA constructs encoding for HIV-1 Gag, Tat and Nef proteins, co-administered with the DNA...

journal_title：Vaccine

authors： Billaut-Mulot O,Idziorek T,Loyens M,Capron A,Bahr GM

更新日期：2001-04-06 00:00:00

abstract：:The purpose of this study was to investigate the utility of various in vitro and in vivo methods to assess the stability of experimental vaccines containing tetanus toxoid (TT) within PLGA microspheres. In vitro, the breakdown of the encapsulating polymers into their acid components led to changes in the structure of ...

journal_title：Vaccine

authors： Sasiak AB,Bolgiano B,Crane DT,Hockley DJ,Corbel MJ,Sesardic D

更新日期：2000-11-22 00:00:00

abstract：BACKGROUND:In 2014 the Kenya National Immunization Technical Advisory Group (KENITAG) was asked by the Ministry of Health to provide an evidence-based recommendation on whether the seasonal influenza vaccine should be introduced into the national immunization program (NIP). METHODS:We reviewed KENITAG manuals, reports...

journal_title：Vaccine

authors： Dawa J,Chaves SS,Ba Nguz A,Kalani R,Anyango E,Mutie D,Muthoka P,Tabu C,Maritim M,Amukoye E,Were F,Kenya National Immunization Technical Advisory Group (KENITAG).

更新日期：2019-01-14 00:00:00