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Early studies on DNA-based immunizations for measles virus.

Abstract：

:DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.

journal_name

Vaccine

journal_title

Vaccine

authors

Yang K,Mustafa F,Valsamakis A,Santoro JC,Griffin DE,Robinson HL

doi

10.1016/s0264-410x(96)00261-7

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

888-91

issue

8

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(96)00261-7

journal_volume

15

pub_type

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