Abstract：
:Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8+ T-cell responses, termed "memory inflation". During murine CMV (MCMV) infection, CD4+ Tcells maintain inflationary virus-specific CD8+ T-cell responses via IL-2 but not IL-21. Adenovirus vector vaccination can induce phenotypically, functionally and transcriptionally similar inflationary responses, but it is not known how IL-21 influences the inflating memory response to adenoviral vaccination. Here, we show that IL-21 is an absolute requirement for induction and maintenance of vaccine-derived inflationary CD8+ T-cell responses. These data indicate that the induction pathway of inflationary Ad-LacZ T-cells is distinct from inflationary MCMV-specific T-cells and is highly dependent on IL-21. Our observations highlight a fundamental difference in the mechanism by which adenovirus vectors and MCMV drive inflationary T-cell responses.
journal_name
Vaccinejournal_title
Vaccineauthors
Gordon CL,Hutchings CL,Highton AJ,Colston JM,Provine NM,Klenerman Pdoi
10.1016/j.vaccine.2018.09.061subject
Has Abstractpub_date
2018-11-12 00:00:00pages
7011-7016issue
46eissn
0264-410Xissn
1873-2518pii
S0264-410X(18)31330-6journal_volume
36pub_type
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