Abstract：
:We produced a Vero cell-derived inactivated Japanese encephalitis vaccine using a serum-free medium, as a substitute for the conventional mouse brain-derived Japanese encephalitis vaccine. The immunogenicity of this cell-derived vaccine was higher than that of the conventional mouse brain-derived vaccine. The results of a clinical study in humans also demonstrated higher immunogenicity of this cell-derived vaccine. No gene mutation was found in the viral structural proteins derived from Vero cells and mouse brain. So, we conducted a lectin blot analysis, assuming differing glycosylation as a cause of the higher immunogenicity in humans. The results demonstrated that vaccine reactivity varied with lectins, particularly with WGA, DBA, MAM, SSA, SBA, and GS-II. Thus, glycosylation differed with the vaccines, suggesting a possible cause of the differing immunogenicity between mice and humans.
journal_name
Vaccinejournal_title
Vaccineauthors
Toriniwa H,Komiya Tdoi
10.1016/j.vaccine.2010.12.038subject
Has Abstractpub_date
2011-02-24 00:00:00pages
1859-62issue
10eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)01811-6journal_volume
29pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Aluminum in the form of aluminum hydroxide, aluminum phosphate or alum has been commonly used as an adjuvant in many vaccines licensed by the US Food and Drug Administration. Chapter 21 of the US Code of Federal Regulations [610.15(a)] limits the amount of aluminum in biological products, including vaccines, to 0.85 m...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(02)00166-4
更新日期：2002-05-31 00:00:00
abstract：:In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(99)00236-4
更新日期：1999-10-01 00:00:00
abstract：:There has been controversy about whether cognitive changes occur in early human immunodeficiency virus (HIV) disease. In those studies reporting cognitive changes, these are typically subclinical, and their relationship to daily and/or occupational functioning has not been addressed. The potential effects of changes m...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90231-l
更新日期：1993-01-01 00:00:00
abstract：:We assessed adult male and female awareness and acceptance of human papillomavirus (HPV) infection and vaccination for cervical cancer prevention, as well as factors associated with willingness to be administered the HPV vaccine. A nationwide population-based interview survey was conducted in Korea. One thousand male ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.11.079
更新日期：2010-02-17 00:00:00
abstract：:Salmonellae are commonly isolated from dogs. The number of dogs infected with Salmonella spp. is surprisingly high and greater than the incidence of clinical disease would suggest. Salmonellosis is common in greyhound kennels. Morbidity can approach 100% in puppies and the mortality ranges to nearly 40%. To date, ther...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00516-3
更新日期：2002-02-22 00:00:00
abstract：:Mycobacterium w (Mw), is a cultivable, non-pathogenic mycobacterium and has been tried extensively as an immunomodulator in leprosy. This has been found to be safe and has shown beneficial immunoprophylactic effect in population based, double blind placebo controlled trials in North India. These effects were also obse...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2007.12.025
更新日期：2008-02-26 00:00:00
abstract：:Potential endpoints for blood stage malaria vaccine efficacy trials include uncomplicated malaria disease, which is hard to differentiate from other febrile illnesses, and mortality, which requires prohibitively large sample sizes. Strictly defined severe malaria predicts malaria-associated mortality where case fatali...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.01.054
更新日期：2004-08-13 00:00:00
abstract：:Influenza is a significant cause of morbidity and mortality for pregnant women and infants worldwide. Influenza vaccination during pregnancy has been shown to be safe and highly effective and should be recommended for all pregnant women before the influenza season. Despite existing recommendations, the vaccine is unde...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.08.013
更新日期：2011-10-06 00:00:00
abstract：:The bioavailability of oseltamivir phosphate and oseltamivir carboxylate were assessed in healthy volunteers when delivered as a solution of the active pharmaceutical ingredient (API) compared with the commercial capsule formulation. The 90% confidence intervals (CIs) for the ratios of the two treatments (capsule vers...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2006.05.080
更新日期：2006-11-10 00:00:00
abstract：:The feasibility of developing a prophylactic vaccine against SARS was assessed by comparing the immune responses elicited by immunizing mice with a recombinant SARS spike glycoprotein (S-protein) formulated with different adjuvants, given by different routes. In both young and aged mice, an intranasal Protollin-formul...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.06.017
更新日期：2007-08-21 00:00:00
abstract：:The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we sh...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.08.020
更新日期：2004-01-26 00:00:00
abstract：:In the face of an almost unprecedented threat of a global pandemic of influenza it is imperative that stockpiling of appropriate drugs and devices begin now. One vital device is an appropriate syringe for delivering vaccine. With the potential for millions to be infected and the vaccine supply severely stretched it is...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.02.056
更新日期：2006-05-29 00:00:00
abstract：:Pertussis has re-emerged as a public health problem in Canada in recent years, emphasizing concerns about the effectiveness of the currently licensed whole-cell vaccine. Following a 1994 outbreak in Nova Scotia, we conducted a case-control study of 483 children aged < 10 years to assess vaccine effectiveness. Ninety-t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00176-4
更新日期：1997-02-01 00:00:00
abstract：IMPORTANCE:Disparities in childhood vaccination rates persist. OBJECTIVE:To evaluate the impact of an enriched medical home intervention using community health workers on improving immunization adherence among young children. DESIGN:The intervention group received home visits from trained community health workers to ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.09.070
更新日期：2015-11-17 00:00:00
abstract：:The highly pathogenic avian H5N1 influenza virus has the potential to incite a global pandemic. Therefore, there is an urgent need to develop effective vaccines against these viruses. Because it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to develop vaccines that will co...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.04.074
更新日期：2009-10-23 00:00:00
abstract：:A passive immunity test (MPT) in suckling mice for the quantification of protective anti-foot-and-mouth disease virus (FMDV) antibodies in serum is described. Comparisons with titres obtained using conventional serum neutralization tests show that for cattle given synthetic peptide vaccines this in vivo assay is a bet...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(91)90311-s
更新日期：1991-01-01 00:00:00
abstract：:Former investigations demonstrated that the envelope glycoprotein E2 could protect pigs from classical swine fever virus (CSFV). Based on these findings, we prepared synthetic peptide vaccine using E2 N-terminal antigenic units B/C and hoped to induce protective activity against lethal challenge of virulent CSFV strai...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00466-8
更新日期：2002-12-13 00:00:00
abstract：:The development of a vaccine for Helicobacter pylori is a key strategy for reducing the worldwide prevalence of H. pylori infection. Although immunization with recombinant B subunit of H. pylori urease (ureB) has yielded promising results, for the most part, these studies relied on the use of strong adjuvant, cholera ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00035-3
更新日期：1999-05-14 00:00:00
abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.02.074
更新日期：2018-04-12 00:00:00
abstract：:Dengue is a significant threat to public health worldwide. Currently, there are no licensed vaccines available for dengue. Takeda Vaccines Inc. is developing a live, attenuated tetravalent dengue vaccine candidate (TDV) that consists of an attenuated DENV-2 strain (TDV-2) and three chimeric viruses containing the prM ...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2015.11.022
更新日期：2015-12-10 00:00:00
abstract：OBJECTIVES:To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN:Cross-sectional online survey. SETTING:Data ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.02.031
更新日期：2017-04-04 00:00:00
abstract：:A National Immunization Technical Advisory Group (NITAG) is an expert advisory committee that provides evidence-based recommendations to the Ministry of Health (MoH) to guide immunization programs and policies. The World Health Organization (WHO), the Initiative for Supporting National Independent Immunization and Vac...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.01.047
更新日期：2013-05-28 00:00:00
abstract：:As a first step towards a vaccine against diarrhoeal disease caused by enterotoxigenic Escherichia coli (ETEC), we have studied the expression of several ETEC antigens in the live attenuated Vibrio cholerae vaccine strain CVD 103-HgR. Colonization factors (CF) CFA/I, CS3, and CS6 were expressed at the surface of V. ch...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.02.052
更新日期：2006-05-15 00:00:00
abstract：:Two live recombinant vaccines (Flc9 and Flc11) against classical swine fever (CSF) were evaluated for their capacity to reduce transmission of virulent CSF virus (CSFV) among vaccinated pigs. In Flc9 the 5' terminal half of the E2 gene of the C-strain, a CSFV vaccine strain, was exchanged with the homologous gene of t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00347-9
更新日期：2001-01-08 00:00:00
abstract：OBJECTIVES:Adoption of human papillomavirus (HPV) vaccination in the US has been slow. In 2011, HPV vaccination of boys was recommended by CDC for routine use at ages 11-12. We conducted and evaluated a social marketing intervention with parents and providers to stimulate HPV vaccination among preteen boys. METHODS:We...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.05.044
更新日期：2014-07-16 00:00:00
abstract：:CpG-DNA is currently attracting attention as an effective and safe vaccine adjuvant to prevent from microbial infections. In this report, we examined the effects of oligo B, which is a synthetic CpG-DNA, in mucosal administration of Bacillus Calmette-Guérin (BCG) and diphtheria toxoid (DT). Co-administration with olig...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.12.025
更新日期：2009-02-18 00:00:00
abstract：:To evaluate the perceived pain, other adverse events, and immunogenicity of influenza virus vaccine administered by needle-free jet injector (JI) compared with that of vaccine administered by needle and syringe (N&S), we randomly assigned 304 healthy young adults to receive one of three dosages (0.5, 0.3, or 0.2 ml) o...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0264-410x(01)00225-0
更新日期：2001-09-14 00:00:00
abstract：:Live Shigella flexneri 2a and Shigella sonnei Phase I vaccine candidate strains with two virulence-reducing markers were constructed through stepwise incorporation of weakly attenuating purine auxotrophy with subsequent rifampicin-resistance (RNA polymerase) mutation to yield optimal attenuation. These vaccine candida...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(90)90173-j
更新日期：1990-02-01 00:00:00
abstract：:M2 is the third integral membrane protein of influenza A. M2e, the extracellular, 23 amino acid residues of M2, has been remarkably conserved in all human influenza A strains. This prompted us to evaluate the use of M2e as a potential broad-spectrum immunogen in a mouse model for influenza infection. Genetic fusion of...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.05.082
更新日期：2006-11-10 00:00:00
abstract：BACKGROUND:Vaccines are specific medicines characterized by two country-specific market access processes: (1) a recommendation by National Immunization Technical Advisory Group (NITAG), and (2) a funding policy decision. OBJECTIVES:The objective of this study was to compare and analyze NITAGs of 13 developed countries...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.09.023
更新日期：2015-01-01 00:00:00
