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Prior DNA vaccination does not interfere with the live-attenuated measles vaccine.

Abstract：

:The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we show that a measles DNA vaccine protects juvenile macaques from pathogenic measles virus challenge and that macaques primed and boosted with this DNA vaccine have anemnestic antibody and cell-mediated responses after vaccination with a live-attenuated canine distemper-measles vaccine. Therefore, this DNA vaccine administered to newborn infants may not hinder the subsequent use of live-attenuated measles vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Premenko-Lanier M,Rota P,Rhodes G,Bellini W,McChesney M

doi

10.1016/j.vaccine.2003.08.020

subject

Has Abstract

pub_date

2004-01-26 00:00:00

pages

762-5

issue

5-6

eissn

0264-410X

issn

1873-2518

pii

S0264410X03006121

journal_volume

22

pub_type

杂志文章

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