Abstract:
:Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneumococcal immunisation for Aboriginal infants in 2001, 16F has become the predominant established serotype in carriage and otitis media in young Aboriginal children. BOX typing and multi-locus sequence typing revealed a diverse population of serotype 16F strains, and evidence of potential capsule switching from a vaccine serotype 4 to a serotype 16F.
journal_name
Vaccinejournal_title
Vaccineauthors
Marsh RL,Smith-Vaughan H,Beissbarth J,Hare K,Kennedy M,Wigger C,Mellon G,Stubbs E,Gadil JR,Pettit A,Mackenzie G,Tipakalippa P,Morris PS,Leach AJdoi
10.1016/j.vaccine.2006.09.016subject
Has Abstractpub_date
2007-03-22 00:00:00pages
2434-6issue
13eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)01018-8journal_volume
25pub_type
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