Abstract:
:The long-term duration of recombinant hepatitis B vaccine-induced immunity among persons vaccinated starting at birth is still not well understood. Waning of vaccine-induced immunity could leave young adults at risk of hepatitis B virus infection due to behavioral or occupational exposures. We followed a cohort of children immunized starting at birth with a 3-dose regimen of recombinant hepatitis B vaccine (5 mcg, 2.5 mcg, 2.5 mcg). They were challenged with a booster dose of the hepatitis B vaccine 10 and 15 years after vaccination to assess anamnestic response as a measure of persistence of protection. Among 108 participants who had lost protective antibody levels against hepatitis B, the majority (>70%) had an anamnestic response to the booster dose; response rates did not decline significantly between 10 and 15 years follow-up periods. A high antibody concentration following primary vaccination was independently associated with an anamnestic response later on in life. Nonetheless, ~20-30% of participants were unable to mount an immune response after boosting. Hepatitis B revaccination might be required for persons vaccinated starting at birth if opportunities for hepatitis B virus exposure exist. Future vaccine recommendations should be based on studies ascertaining protection against clinically significant disease.
journal_name
Vaccinejournal_title
Vaccineauthors
Chaves SS,Fischer G,Groeger J,Patel PR,Thompson ND,Teshale EH,Stevenson K,Yano VM,Armstrong GL,Samandari T,Kamili S,Drobeniuc J,Hu DJdoi
10.1016/j.vaccine.2011.12.106subject
Has Abstractpub_date
2012-02-21 00:00:00pages
1644-9issue
9eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)02067-6journal_volume
30pub_type
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