Decreasing invasive pneumococcal disease in the elderly: a state-level analysis.


:Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.






McBean AM,Jung K,Hebert PL




Has Abstract


2006-07-07 00:00:00
















  • A genetically-defined riboflavin auxotroph of Actinobacillus pleuropneumoniae as a live attenuated vaccine.

    abstract::Actinobacillus pleuropneumoniae is a gram negative pleiomorphic rod that is the causative agent of a severe, highly infectious and often fatal pleuropneumonia in swine. We have previously reported the construction of genetically-defined stable riboflavin auxotrophs by replacement of a portion of the APP riboflavin bio...


    pub_type: 临床试验,杂志文章


    authors: Fuller TE,Thacker BJ,Duran CO,Mulks MH

    更新日期:2000-06-15 00:00:00

  • Intranasal vaccination with ebola virus GP amino acids 258-601 protects mice against lethal challenge.

    abstract::Ebola virus (EBOV) disease (EVD) leads to lethal hemorrhagic fever with a case fatality rate as high as 90%, thus posing a serious global public health concern. However, while several vaccines based on the EBOV glycoprotein have been confirmed to be effective in animal experiments, no licensed vaccines or effective tr...


    pub_type: 杂志文章


    authors: Su QD,He SH,Yi Y,Qiu F,Lu XX,Jia ZY,Meng QL,Fan XT,Tian RG,Audet J,Qiu XG,Bi SL

    更新日期:2018-10-01 00:00:00

  • Effects of a multi-faceted program to increase influenza vaccine uptake among health care workers in nursing homes: A cluster randomised controlled trial.

    abstract::Despite the recommendation of the Dutch association of nursing home physicians (NVVA) to be immunized against influenza, vaccine uptake among HCWs in nursing homes remains unacceptably low. Therefore we conducted a cluster randomised controlled trial among 33 Dutch nursing homes to assess the effects of a systematical...


    pub_type: 杂志文章,随机对照试验


    authors: Looijmans-van den Akker I,van Delden JJ,Verheij TJ,van der Sande MA,van Essen GA,Riphagen-Dalhuisen J,Hulscher ME,Hak E

    更新日期:2010-07-12 00:00:00

  • Correlates of protection of serotype-specific capsular antibody and invasive Group B Streptococcus disease in South African infants.

    abstract:BACKGROUND:Vaccinating pregnant women may prevent invasive Group B Streptococcus (GBS) disease in their young infants. In a low-middle income setting, we sought to determine an association between natural maternal antibody responses and the development of invasive GBS disease. METHODS:We undertook a matched case-contr...


    pub_type: 杂志文章


    authors: Dangor Z,Kwatra G,Izu A,Adrian P,Cutland CL,Velaphi S,Ballot D,Reubenson G,Zell ER,Lala SG,Madhi SA

    更新日期:2015-11-27 00:00:00

  • In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.

    abstract::Targeting immune checkpoint receptors has emerged as an effective strategy to induce immune-mediated cancer regression in the subset of patients who have significant pre-existing anti-tumor immunity. For the remainder, effective anti tumor responses may require vaccination. Radiotherapy, traditionally used to achieve ...


    pub_type: 杂志文章,评审


    authors: Vanpouille-Box C,Pilones KA,Wennerberg E,Formenti SC,Demaria S

    更新日期:2015-12-16 00:00:00

  • Immunisation practices in centres caring for children with perinatally acquired HIV: A call for harmonisation.

    abstract:BACKGROUND:Current national immunisation schedules differ between countries in terms of vaccine formulation, timing of vaccinations and immunisation programme funding and co-ordination. As a result, some HIV infected paediatric population may be left susceptible to vaccine preventable infections. Vaccines used in healt...


    pub_type: 杂志文章,多中心研究


    authors: Bamford A,Manno EC,Mellado MJ,Spoulou V,Marques L,Scherpbier HJ,Niehues T,Oldakowska A,Rossi P,Palma P,PENTA-vac Group.

    更新日期:2016-11-04 00:00:00

  • Management of acute and fulminant hepatitis A.

    abstract::Symptomatic viral hepatitis A usually only requires supportive therapy and the majority of cases are managed in the community. The prodromal symptoms of nausea, anorexia and lethargy tend to improve with the onset of clinical jaundice. Fulminant hepatic failure is said to be an uncommon complication, occurring in only...


    pub_type: 杂志文章,评审


    authors: O'Grady J

    更新日期:1992-01-01 00:00:00

  • Immunogenicity of an alum-adsorbed synthetic multiple-antigen peptide based on B- and T-cell epitopes of the Plasmodium falciparum CS protein: possible vaccine application.

    abstract::Multiple-antigen peptides (MAPs), containing B- and T-cell epitopes of the Plasmodium falciparum circumsporozoite (CS) protein, have been designed to overcome the limitations of first-generation peptide vaccines caused by low epitope density, carrier toxicity and the lack of parasite-derived T-cell epitopes. The immun...


    pub_type: 杂志文章


    authors: de Oliveira GA,Clavijo P,Nussenzweig RS,Nardin EH

    更新日期:1994-08-01 00:00:00

  • Transepithelial immunomodulation by cholera toxin and non-toxic derivatives.

    abstract::Comparative analyses of murine dendritic cells (DC) isolated from the skin and from the intestinal mucosa after exposure to cholera toxin and its non-toxic B subunit disclose striking differences regarding the migratory and functional behaviour of these cells. The nature of the epithelial microenvironment, especially ...


    pub_type: 杂志文章


    authors: Anjuère F,Luci C,Hervouet C,Rousseau D,Czerkinsky C

    更新日期:2006-04-12 00:00:00

  • Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit.

    abstract::Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation i...


    pub_type: 临床试验,杂志文章


    authors: Lewis DJ,Castello-Branco LR,Novotny P,Dougan G,Poulton TA,Griffin GE

    更新日期:1993-01-01 00:00:00

  • Global Vaccine Action Plan Lessons Learned II: Stakeholder Perspectives.

    abstract:INTRODUCTION:The Global Vaccine Action Plan (GVAP), unanimously endorsed by the World Health Assembly in 2012, defined an ambitious strategy to improve immunization. At the end of the decade, significant progress has been made but four of the five GVAP goals are likely to be missed. This report describes a set of surve...


    pub_type: 杂志文章


    authors: Hwang A,Veira C,Malvolti S,Cherian T,MacDonald N,Steffen C,Jones I,Hinman A,Mantel C

    更新日期:2020-07-14 00:00:00

  • Beta-propiolactone treatment impairs the biological activity of residual DNA from BHK-21 cells infected with rabies virus.

    abstract::The effects of beta-propiolactone (BPL), an alkylating and virus inactivating agent, on the structural and in vitro biological properties of different DNA preparations from BHK-21 cells were investigated. Both uninfected and rabies virus-infected cells were used. Purified cellular DNA (celDNA) was used as the referenc...


    pub_type: 杂志文章


    authors: Morgeaux S,Tordo N,Gontier C,Perrin P

    更新日期:1993-01-01 00:00:00

  • Poor knowledge of vaccination recommendations and negative attitudes towards vaccinations are independently associated with poor vaccination uptake among adults - Findings of a population-based panel study in Lower Saxony, Germany.

    abstract:OBJECTIVES:The aims of this study were to (a) assess knowledge of official vaccination recommendations and attitudes towards vaccinations among adults and (b) examine their association with vaccination uptake among adults. METHODS:This study was part of the HaBIDS study (Hygiene and Behaviour Infectious Diseases Surve...


    pub_type: 杂志文章


    authors: Akmatov MK,Rübsamen N,Deyneko IV,Karch A,Mikolajczyk RT

    更新日期:2018-04-25 00:00:00

  • Human lactoferrin proteolytic activity: analysis of the cleaved region in the IgA protease of Haemophilus influenzae.

    abstract::Human lactoferrin proteolytically cleaves and inactivates two colonization factors of non-typable Haemophilus influenzae, the IgA protease precursor protein (Iga), and Hap, the non-pilus adhesin by which microoganisms adhere to host epithelial cells and form microcolonies. Iga and Hap are homologous proteins that are ...


    pub_type: 杂志文章


    authors: Plaut AG,Qiu J,St Geme JW 3rd

    更新日期:2000-12-08 00:00:00

  • Plaque purification as a method to mitigate the risk of adventitious-agent contamination in influenza vaccine virus seeds.

    abstract::At present, the seed viruses for the manufacture of licensed seasonal inactivated influenza vaccines in the United States are derived from primary egg isolates as a result of concerns associated with adventitious agents. According to the prevailing view, the passage of influenza viruses through eggs serves as a filter...


    pub_type: 杂志文章


    authors: Murata H,Macauley J,Lewis AM Jr,Peden K

    更新日期:2011-04-12 00:00:00

  • Overview of rabies post-exposure prophylaxis access, procurement and distribution in selected countries in Asia and Africa, 2017-2018.

    abstract:BACKGROUND:Rabies is a neglected zoonotic disease with a global burden of approximately 59,000 human deaths a year. Once clinical symptoms appear, rabies is almost invariably fatal; however, with timely and appropriate post-exposure prophylaxis (PEP) consisting of wound washing, vaccine, and in some cases rabies immuno...


    pub_type: 杂志文章,评审


    authors: Sreenivasan N,Li A,Shiferaw M,Tran CH,Wallace R,Blanton J,Knopf L,Abela-Ridder B,Hyde T,Working group on Rabies PEP logistics.

    更新日期:2019-10-03 00:00:00

  • Past, present and future of HIV vaccine trials in developing countries.

    abstract::A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human vo...


    pub_type: 杂志文章,评审


    authors: Esparza J,Osmanov S,Pattou-Markovic C,Touré C,Chang ML,Nixon S

    更新日期:2002-05-06 00:00:00

  • Production of antibodies and antibody fragments in plants.

    abstract::Our current knowledge allows the generation of transgenic plants that efficiently produce heterologous proteins from plant, bacterial, fungal or animal origin. Among all types of recombinant proteins, antibodies are particularly attractive because of their ability to specifically recognize and bind virtually any type ...


    pub_type: 杂志文章,评审


    authors: Peeters K,De Wilde C,De Jaeger G,Angenon G,Depicker A

    更新日期:2001-03-21 00:00:00

  • Recombinant enterotoxins as vaccines against Escherichia coli-mediated diarrhoea.

    abstract::A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability t...


    pub_type: 杂志文章


    authors: Aitken R,Hirst TR

    更新日期:1993-01-01 00:00:00

  • Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA.

    abstract::Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the pneumococcal type 1 pilus declined dramatically, a decline associated with the elimination of vaccine-type (VT) strains. Here we show that between 2004 and 2007, th...


    pub_type: 杂志文章


    authors: Regev-Yochay G,Hanage WP,Trzcinski K,Rifas-Shiman SL,Lee G,Bessolo A,Huang SS,Pelton SI,McAdam AJ,Finkelstein JA,Lipsitch M,Malley R

    更新日期:2010-07-05 00:00:00

  • A reduction in chronic hepatitis B virus infection prevalence among children in Vietnam demonstrates the importance of vaccination.

    abstract:BACKGROUND:Vietnam has high endemic hepatitis B virus infection with >8% of adults estimated to have chronic infection. Hepatitis B vaccine was first introduced in the national childhood immunization program in 1997 in high-risk areas, expanded nationwide in 2002, and included birth dose vaccination in 2003. This surve...


    pub_type: 杂志文章


    authors: Nguyen TH,Vu MH,Nguyen VC,Nguyen LH,Toda K,Nguyen TN,Dao S,Wannemuehler KA,Hennessey KA

    更新日期:2014-01-03 00:00:00

  • Has the public lost confidence in vaccines because of a vaccine scandal in China.

    abstract:BACKGROUND:A vaccine manufacturer in China and regulatory authorities have been the focus of widespread outrage due to a vaccine scandal. We conducted a rapid survey during a time of intense mainstream and social media attention to determine whether the public's confidence in vaccines was affected. METHODS:We selected...


    pub_type: 杂志文章


    authors: Han B,Wang S,Wan Y,Liu J,Zhao T,Cui J,Zhuang H,Cui F

    更新日期:2019-08-23 00:00:00

  • Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques.

    abstract::Plasmid DNA is a promising vaccine platform that has been shown to be safe and able to be administered repeatedly without vector interference. Enhancing the potency of DNA vaccination through co-delivery of molecular adjuvants is one strategy currently under investigation. Here we describe the use of the novel chemoki...


    pub_type: 杂志文章


    authors: Kraynyak KA,Kutzler MA,Cisper NJ,Khan AS,Draghia-Akli R,Sardesal NY,Lewis MG,Yan J,Weiner DB

    更新日期:2010-02-23 00:00:00

  • Influenza vaccination rates in Ontario children: implications for universal childhood vaccination policy.

    abstract::The aims of this study were to estimate influenza vaccination coverage for children during the 2006-2007 influenza season in Ontario, Canada, where universal vaccination is available, and to compare the rate among children aged 6-23 months with corresponding rates from other Canadian provinces that specifically target...


    pub_type: 杂志文章


    authors: Moran K,Maaten S,Guttmann A,Northrup D,Kwong JC

    更新日期:2009-04-14 00:00:00

  • Changes in pathogens and pneumococcal serotypes causing community-acquired pneumonia in The Netherlands.

    abstract:BACKGROUND:In 2006 a 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in the immunisation programme for infants in The Netherlands and replaced by PCV10 in 2011. Limited data exist about the impact of PCV on the aetiology of CAP as a whole. The aim of the present study is to describe the overall changes in...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Vestjens SMT,Wagenvoort GHJ,Grutters JC,Meek B,Aldenkamp AF,Vlaminckx BJM,Bos WJW,Rijkers GT,van de Garde EMW

    更新日期:2017-07-24 00:00:00

  • From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination.

    abstract::Although studies have suggested that a patient's perceived cost-benefit of a medical intervention could affect his or her utilization of the intervention, the economic value of influenza vaccine from the patient's perspective remains unclear. Therefore, we developed a stochastic decision analytic computer model repres...


    pub_type: 杂志文章


    authors: Lee BY,Bacon KM,Donohue JM,Wiringa AE,Bailey RR,Zimmerman RK

    更新日期:2011-03-03 00:00:00

  • Salmonella Enteritidis ghost vaccine carrying the hemagglutinin globular head (HA1) domain from H1N1 virus protects against salmonellosis and influenza in chickens.

    abstract::This study evaluated the attenuated Salmonella Enteritidis (SE) ghost strain JOL2114 (Δlon ΔcpxR Δasd), which displays on the bacterial surface the H1N1 hemagglutinin globular head portion (HA1; amino acid residues 63-286) on the bacterial surface for protective efficacy against Salmonella and H1N1 challenge in the ch...


    pub_type: 杂志文章


    authors: Won G,Senevirathne A,Lee JH

    更新日期:2020-06-09 00:00:00

  • Immune responses and protective efficacy of a recombinant swinepox virus expressing HA1 against swine H1N1 influenza virus in mice and pigs.

    abstract::Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a potent threat to human health. Although immunization with recombinant poxviruses expressing protective antigens as vaccines has been widely used for against many infectious diseases, development of recombinant swinepox virus (...


    pub_type: 杂志文章


    authors: Xu J,Huang D,Liu S,Lin H,Zhu H,Liu B,Lu C

    更新日期:2012-04-26 00:00:00

  • Determinants of willingness to pay for self-paid vaccines in China.

    abstract:BACKGROUND:While vaccines not covered by China's Expanded Program on Immunization can be received voluntarily with out-of-pocket payment, the uptake of self-paid vaccines in China is low. OBJECTIVE:To investigate willingness to pay (WTP) for self-paid vaccines and its determinants in China. METHODS:We interviewed 216...


    pub_type: 杂志文章


    authors: Hou Z,Jie Chang,Yue D,Fang H,Meng Q,Zhang Y

    更新日期:2014-07-31 00:00:00

  • Evaluation of endotoxin content of diphtheria-tetanus-acellular pertussis combined (DTaP) vaccines that interfere with the bacterial endotoxin test.

    abstract::Applicability of the endotoxin test to diphtheria-tetanus-acellular pertussis combined (DTaP) vaccines was examined. We found some DTaP vaccines that strongly interfered with Limulus amoebocyte lysate (LAL) activity of endotoxin without affecting lethal activity of endotoxin in D-galactosamine-treated mice. LAL activi...


    pub_type: 杂志文章


    authors: Ochiai M,Kataoka M,Toyoizumi H,Kamachi K,Yamamoto A,Horiuchi Y

    更新日期:2003-05-16 00:00:00