The adjuvant effect of synthetic oligodeoxynucleotide containing CpG motif converts the anti-Haemophilus influenzae type b glycoconjugates into efficient anti-polysaccharide and anti-carrier polyvalent vaccines.

abstract：:Theileria parva kills over one million cattle annually in sub-Saharan Africa. Parasite genetic complexity, cellular response immunodominance, and bovine MHC diversity have precluded traditional vaccine development. One potential solution is gene gun (GG) immunization, which enables simultaneous administration of one o...

journal_title：Vaccine

authors： Fry LM,Bastos RG,Stone BC,Williams LB,Knowles DP,Murphy SC

更新日期：2019-03-14 00:00:00

abstract：:Prior to routine immunisation, Haemophilus influenzae serotype b (Hib) was a major cause of serious bacterial infections, particularly in young children. In the United Kingdom, introduction of the Hib conjugate vaccine into the national childhood immunisation schedule has led to a sustained decline in invasive Hib dis...

journal_title：Vaccine

authors： Townsend K,Ladhani SN,Findlow H,Borrow R

更新日期：2014-09-29 00:00:00

abstract：:In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...

journal_title：Vaccine

authors： Uddowla S,Freytag LC,Clements JD

更新日期：2007-11-19 00:00:00

abstract：:DNA vaccination is particularly efficient for induction of cytotoxic T-lymphocyte (CTL) response. In our experiments, we used MHC(B) congenic chicken lines CB and CC (regressors and progressors of v-src-induced tumours, respectively) and a mutated, non-oncogenic v-src gene construct as the DNA vaccine. A high degree o...

journal_title：Vaccine

authors： Plachý JV,Hejnar JV,Trtková K,Trejbalová K,Svoboda J,Hála K

更新日期：2001-08-14 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (...

journal_title：Vaccine

authors： Czub M,Weingartl H,Czub S,He R,Cao J

更新日期：2005-03-18 00:00:00

abstract：:Influenza vaccines minimize the risk of influenza-related morbidity, complication, and death in elderly people. Although evaluating vaccine effectiveness (VE) is important for promoting immunization programs and coping with influenza epidemics, it is difficult to evaluate its effectiveness in Japan, where no framework...

journal_title：Vaccine

authors： Hara M,Hirota Y

更新日期：2017-08-24 00:00:00

abstract：:Preclinical vaccine efficacy studies are generally limited to certain read out parameters such as assessment of virus titers in swabs and organs, clinical signs, serum antibody titers, and pathological changes. These parameters are not always routinely applied and not always scheduled in a logical standardized way. We...

journal_title：Vaccine

authors： Veldhuis Kroeze EJ,Stittelaar KJ,Teeuwsen VJ,Dijkshoorn ML,van Amerongen G,de Waal L,Kuiken T,Krestin GP,Hinkula J,Osterhaus AD

更新日期：2012-12-07 00:00:00

abstract：BACKGROUND:Vaccination coverage in Bosnia and Herzegovina has been declining over recent years. A World Health Organization Tailoring Immunization Programmes (TIP) project is underway to gain insights into the underlying reasons for this, to develop tailored interventions. As part of TIP, this study aimed to investigat...

journal_title：Vaccine

authors： Musa S,Skrijelj V,Kulo A,Habersaat KB,Smjecanin M,Primorac E,Becirovic D,Jackson C

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Routine administration of all age-appropriate doses of vaccines during the same visit is recommended for children by the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP). METHODS:Evaluate the potentially achievable vaccination coverage for ≥4 doses of di...

journal_title：Vaccine

authors： Zhao Z,Smith PJ,Hill HA

更新日期：2016-06-08 00:00:00

abstract：INTRODUCTION:In 2005, in Finland, the whole-cell pertussis vaccine was replaced by acellular given at 3-5-12months, and boosters at 4 and 11-15years of age. From July 2012, military conscripts have been offered a pertussis booster dose. Conscription is mandatory for Finnish men, and >95% were 19-21years old when enroll...

journal_title：Vaccine

authors： Zöldi V,Sane J,Nohynek H,Virkki M,Hannila-Handelberg T,Mertsola J

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Efforts to develop a Clostridium difficile vaccine are underway; identification of patients at risk for C. difficile infection (CDI) is critical to inform vaccine trials. We identified groups at high risk of CDI ≥ 2 8 days after hospital discharge. METHODS:Hospital discharge data and pharmacy data from two ...

journal_title：Vaccine

authors： Baggs J,Yousey-Hindes K,Ashley ED,Meek J,Dumyati G,Cohen J,Wise ME,McDonald LC,Lessa FC

更新日期：2015-11-17 00:00:00

abstract：:Concerns over migratory bison (Bison bison) at Yellowstone National Park transmitting brucellosis (Brucella abortus) to cattle herds on adjacent lands led to proposals for bison vaccination. We developed an individual-based model to evaluate how brucellosis infection might respond under alternate vaccination strategie...

journal_title：Vaccine

authors： Treanor JJ,Johnson JS,Wallen RL,Cilles S,Crowley PH,Cox JJ,Maehr DS,White PJ,Plumb GE

更新日期：2010-10-01 00:00:00

abstract：:The recovery of wild type and attenuated human parainfluenza type 3 (PIV3) recombinant viruses has made possible a new strategy to rapidly generate a live-attenuated vaccine virus fof PIV1. We previously replaced the coding sequences for the hemagglutinin-neuraminidase (HN) and fusion (F) proteins of PIV3 with those o...

journal_title：Vaccine

authors： Tao T,Skiadopoulos MH,Durbin AP,Davoodi F,Collins PL,Murphy BR

更新日期：1999-03-05 00:00:00

abstract：BACKGROUND:In September 2011, the German Standing Committee on Vaccinations (STIKO) changed their recommendation regarding the mumps-measles-rubella-varicella vaccination (MMRV). We compared the immunization rates against MMRV in Germany before and after the STIKO intervention. METHODS:We recorded the immunization sta...

journal_title：Vaccine

authors： Sanftenberg L,Schrörs HJ,Schelling J

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...

journal_title：Vaccine

authors： Bogler L,Jantos N,Bärnighausen T,Vollmer S

更新日期：2019-08-14 00:00:00

abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

journal_title：Vaccine

authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

更新日期：2010-04-09 00:00:00

abstract：BACKGROUND:Elimination of congenital rubella syndrome depends not only on effective childhood immunization but also on the identification and immunization of rubella susceptible women. We assessed rubella susceptibility among pregnant women and evaluated the adherence and response to postpartum immunization with measle...

journal_title：Vaccine

authors： Vilajeliu A,García-Basteiro AL,Valencia S,Barreales S,Oliveras L,Calvente V,Goncé A,Bayas JM

更新日期：2015-04-08 00:00:00

abstract：:We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

journal_title：Vaccine

authors： Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

更新日期：2000-06-01 00:00:00

abstract：:Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs...

journal_title：Vaccine

authors： Zengel J,Phan SI,Pickar A,Xu P,He B

更新日期：2017-07-13 00:00:00

abstract：OBJECTIVE:The study objectives were to evaluate injection practices in China in the post GAVI project era and provide guidance for policy makers to update national standards for injection practices and further improve vaccination services. METHODS:We conducted a national stratified, cross-sectional survey in October 2...

journal_title：Vaccine

authors： Wu Z,Cui F,Chen Y,Miao N,Gong X,Luo H,Wang F,Zheng H,Kane M,Hadler SC,Hutin YJ,Liang X,Yang W

更新日期：2013-12-27 00:00:00

abstract：BACKGROUND:This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy (cART)-t...

journal_title：Vaccine

authors： Herasimtschuk A,Downey J,Nelson M,Moyle G,Mandalia S,Sikut R,Adojaan M,Stanescu I,Gotch F,Imami N

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:Each year, approximately 1,066 Cambodian children under five years old die of diarrhea, and 51% of these deaths are due to rotavirus gastroenteritis. Quantifying childhood hospitalizations caused by severe rotavirus infections is also important in demonstrating disease burden caused by this virus. The object...

journal_title：Vaccine

authors： Angkeabos N,Rin E,Vichit O,Chea C,Tech N,Payne DC,Fox K,Heffelfinger JD,Grabovac V,Nyambat B,Diorditsa S,Samnang C,Hossain MS

更新日期：2018-12-14 00:00:00

abstract：:Flavobacterium psychrophilum is a well-known pathogen causing significant problems in aquaculture worldwide. In recent years an increasing number of disease outbreaks caused by F. psychrophilum has been reported on juvenile and post smolts of rainbow trout (Oncorhynchus mykiss) in Norway. The current study was perform...

journal_title：Vaccine

authors： Fredriksen BN,Olsen RH,Furevik A,Souhoka RA,Gauthier D,Brudeseth B

更新日期：2013-04-08 00:00:00

abstract：:Immunization of hairless mice with a TK-, ACVr, non-pathogenic herpes simplex virus (HSV) type 1 mutant protected the mice against reinfection with lethal doses of the parental pathogenic HSV strain. The protection conferred by the mutant against the establishment of latency after reinfection with the parental strain ...

journal_title：Vaccine

authors： Klein RJ,Kaley LA,Friedman-Kien AE

更新日期：1984-09-01 00:00:00

abstract：:Increases in global travel, trade and urbanisation are leading to greater incidence of zoonotic disease, and livestock are often a key link in the spread of disease to humans. As such, livestock vaccination strategies, as a part of broader biosecurity solutions, are critical to both animal and human health. Importantl...

journal_title：Vaccine

authors： Layton DS,Choudhary A,Bean AGD

更新日期：2017-10-20 00:00:00

abstract：:A reverse genetics infectious bursal disease virus (RG-IBDV) that contained authentic 3' RNA sequence was characterized both in vitro and in vivo. LP1-IBDV, a cell line-adapted IBDV strain variant E (VE) was used as the parent virus for constructing viral cDNA clones. Authentic 3' RNA sequence was generated by using c...

journal_title：Vaccine

authors： Mosley YY,Wu CC,Lin TL

更新日期：2013-01-11 00:00:00

abstract：:Systemic and mucosal immune responses were effectively induced following the subcutaneous administration of Haemophilus influenzae type b oligosaccharide conjugated to diphtheria toxoid vaccine in a formulation containing the active form of vitamin D3. IgA and IgG antibodies with specificity for both the protein and o...

journal_title：Vaccine

authors： Enioutina EY,Visic D,McGee ZA,Daynes RA

更新日期：1999-08-06 00:00:00

abstract：:A small number of serotypes are responsible for most invasive pneumococcal disease in children worldwide. Serotypes 1 and 5 were among the first pneumococcal serotypes to be identified, reflecting their great prominence as causes of disease in the early part of the 20th century. In the antibiotic era, these serotypes ...

journal_title：Vaccine

authors： Hausdorff WP

更新日期：2007-03-22 00:00:00

abstract：:A bovine herpesvirus 4 was isolated from the milk cell fraction of a healthy cow and his full genome cloned as a bacterial artificial chromosome. So cloned viral genome was used as a vector platform to deliver in vitro and in vivo an optimized secreted chimeric peptide obtained by the fusion of the bovine viral diarrh...

journal_title：Vaccine

authors： Donofrio G,Sartori C,Franceschi V,Capocefalo A,Cavirani S,Taddei S,Flammini CF

更新日期：2008-11-11 00:00:00

abstract：:Equine influenza is a contagious diseases caused by equine influenza viruses which belong to the orthomyxovirus family. Outbreaks of equine influenza cause severe economic loses to the horse industry and consequently competition horses are required to be regularly vaccinated against equine influenza. Currently availab...

journal_title：Vaccine

authors： Heldens JG,Pouwels HG,Derks CG,Van de Zande SM,Hoeijmakers MJ

更新日期：2009-09-04 00:00:00