Abstract：
:The hemagglutinin/protease (HA/P) seems to be an attractive locus for the insertion of heterologous tags in live cholera vaccine strains. A deltaCTXphi spontaneous mutant derived from a pathogenic strain of O139 Vibrio cholerae was sequentially manipulated to obtain hapA Colon, two colons celA derivatives which were later improved in their environmental safety by means of a thyA mutation. All the strains here obtained showed similar phenotypes in traits known to be remarkable for live cholera vaccines irrespective of their motility phenotypes, although the hapA mutants had a 10-fold decrease in their colonisation capacity compared with their parental strains in the infant mouse cholera model. However, the subsequent thyA mutation did not affect their colonisation properties in the same model. These preliminary results pave the way for further clinical assays to confirm the possibilities of these vaccine prototypes as safe and effective tools for the prevention of O139 cholera.
journal_name
Vaccinejournal_title
Vaccineauthors
Ledón T,Valle E,Valmaseda T,Cedré B,Campos J,Rodríguez BL,Marrero K,García H,García L,Fando Rdoi
10.1016/s0264-410x(02)00412-7subject
Has Abstractpub_date
2003-03-07 00:00:00pages
1282-91issue
11-12eissn
0264-410Xissn
1873-2518pii
S0264410X02004127journal_volume
21pub_type
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