Abstract：
:The identification of new vaccine candidates for leptospirosis is of great interest. This paper describes the identification of two homologous immunogenic proteins, LigA-m and LigB-m, of Leptospira interrogans serovar manilae strain UP-MMC-NIID, which show strong similarity with LigA found recently in L. interrogans serovar pomona. Southern blot analysis indicated the conservation of the lig genes among pathogenic leptospires. LigA-m protein was shown to be a surface-exposed lipoprotein expressed during in vitro culture. Both LigA-m and LigB-m induced protective immunity against a challenge with a homologous serovar of L. interrogans in mice. Furthermore, patients' sera infected with heterologous serovars' strains contained antibodies against LigA-m and LigB-m. Our results suggest that LigA-m and LigB-m proteins are new vaccine candidates for the prevention of leptospirosis.
journal_name
Vaccinejournal_title
Vaccineauthors
Koizumi N,Watanabe Hdoi
10.1016/j.vaccine.2003.10.007subject
Has Abstractpub_date
2004-03-29 00:00:00pages
1545-52issue
11-12eissn
0264-410Xissn
1873-2518pii
S0264410X03007333journal_volume
22pub_type
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