Abstract：
:Enteroviruses elicit protective mucosal immune responses that could be harnessed as part of a strategy to prevent sexual transmission of the human immunodeficiency virus-1 (HIV-1). We report the construction of replication-competent recombinant vectors of coxsackievirus B3 (CVB3) that express one or more portions of the HIV-1 Gag protein. Vectors containing the capsid domain of Gag were initially genetically unstable with protein expression lost after brief passage in tissue culture. Codon modification to increase the G/C content of the HIV-1 capsid sequence resulted in enhanced genetic stability of CVB3 vectors during in vitro passage. Cells infected with a vector expressing the matrix (MA) subunit of the HIV-1 Gag protein were susceptible to lysis by CD8 T cell clones specific for the SL9 epitope found within MA. These studies suggest that CVB3 vectors may be useful as vaccine vector candidates, if hurdles in class I antigen presentation and stability can be overcome.
journal_name
Vaccinejournal_title
Vaccineauthors
Miller JP,Geng Y,Ng HL,Yang OO,Krogstad Pdoi
10.1016/j.vaccine.2009.04.035subject
Has Abstractpub_date
2009-06-19 00:00:00pages
3992-4000issue
30eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00580-5journal_volume
27pub_type
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