Evaluation of hepatitis B vaccine immunogenicity among older adults during an outbreak response in assisted living facilities.


BACKGROUND:During the past decade, in the United States, an increasing number of hepatitis B outbreaks have been reported in assisted living facilities (ALFs) as a result of breaches in infection control practices. We evaluated the seroprotection rates conferred by hepatitis B vaccine among older adults during a response to an outbreak that occurred in multiple ALFs and assessed the influence of demographic and clinical factors on vaccine response. METHODS:Residents were screened for hepatitis B and C infection prior to vaccination and susceptible residents were vaccinated against hepatitis B with one dose of 20 μg Engerix-B™ (GSK) given at 0, 1, and 4 months. Blood samples were collected 80-90 days after the third vaccine dose to test for anti-HBs levels. RESULTS:Of the 48 residents who had post-vaccination blood specimens collected after the third vaccine dose, 16 (33.3%) achieved anti-HBs concentration ≥10 mIU/mL. Age was a significant determinant of seroprotection with rates decreasing from 88% among persons aged ≤60 years to 12% among persons aged ≥90 years (p=0.001). Geometric mean concentrations were higher among non-diabetic than diabetic residents, however, the difference was not statistically significant (5.1 vs. 3.8 mIU/mL, p=0.7). CONCLUSIONS:These findings highlight that hepatitis B vaccination is of limited effectiveness when administered to older adults. Improvements in infection control and vaccination at earlier ages might be necessary to prevent spread of infection in ALFs.






Tohme RA,Awosika-Olumo D,Nielsen C,Khuwaja S,Scott J,Xing J,Drobeniuc J,Hu DJ,Turner C,Wafeeg T,Sharapov U,Spradling PR




Has Abstract


2011-11-21 00:00:00
















  • Field evaluation of vaccine safety.

    abstract::Surveillance of adverse events in the field represents an essential part of vaccination strategies. Safety studies conducted before vaccine licensure have often not enough power to detect rare or long-term adverse events. Furthermore, adverse events may be caused by incorrect procedures of storage or administration. C...


    pub_type: 杂志文章,评审


    authors: Tozzi AE

    更新日期:2004-05-07 00:00:00

  • Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle.

    abstract::Safe RSV vaccine development has challenged the medical community since a formalin-killed RSV vaccine caused disease exacerbation in the 1960s. Disease was replicated using the bovine RSV system in one of two studies. The studies differed in viral protein dose and length of time between vaccination and infection. Dise...


    pub_type: 杂志文章


    authors: Kalina WV,Woolums AR,Berghaus RD,Gershwin LJ

    更新日期:2004-03-29 00:00:00

  • Overcoming barriers to HPV vaccination: non-inferiority of antibody response to human papillomavirus 16/18 vaccine in adolescents vaccinated with a two-dose vs. a three-dose schedule at 21 months.

    abstract::For middle and low-income countries, the cost of HPV vaccines remains challenging. We conducted an open-label nonrandomized clinical trial evaluating immune response to the HPV-16/18 AS04-adjuvanted vaccine administered on a standard (months (M) 0-1-6) versus extended schedule (M 0-6-60) at 7, 21, 60, 72 and 120 month...


    pub_type: 临床试验,杂志文章


    authors: Lazcano-Ponce E,Stanley M,Muñoz N,Torres L,Cruz-Valdez A,Salmerón J,Rojas R,Herrero R,Hernández-Ávila M

    更新日期:2014-02-03 00:00:00

  • Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy.

    abstract::The calculation of p(epitope) values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the p(epitope) value to equine influenza vaccine strain selection was assessed. There was a negative correlation between p(epitope) value and vaccine efficacy ...


    pub_type: 杂志文章


    authors: Daly JM,Elton D

    更新日期:2013-12-09 00:00:00

  • Immunization of rabbits with Glossina pallidipes tsetse fly midgut proteins: effects on the fly and trypanosome transmission.

    abstract::Proteins isolated from the midgut of Glossina pallidipes were used to immunize rabbits and their efficacy as vaccine candidate(s) against the fly, and their potential to block transmission of Trypanosoma brucei rhodesiense assessed. Two fractions, detergent (DET) and aqueous (AQ) fractions were separated using a non-i...


    pub_type: 杂志文章


    authors: Kinyua JK,Nguu EK,Mulaa F,Ndung'u JM

    更新日期:2005-05-31 00:00:00

  • Awareness of and attitude towards human papillomavirus infection and vaccination for cervical cancer prevention among adult males and females in Korea: a nationwide interview survey.

    abstract::We assessed adult male and female awareness and acceptance of human papillomavirus (HPV) infection and vaccination for cervical cancer prevention, as well as factors associated with willingness to be administered the HPV vaccine. A nationwide population-based interview survey was conducted in Korea. One thousand male ...


    pub_type: 杂志文章


    authors: Oh JK,Lim MK,Yun EH,Lee EH,Shin HR

    更新日期:2010-02-17 00:00:00

  • Impaired cellular immune response to tetanus toxoid but not to cytomegalovirus in effectively HAART-treated HIV-infected children.

    abstract::Despite of highly active antiretroviral therapy, the response to vaccines in HIV-infected children is poor and short-lived, probably due to a defect in cellular immune responses. We compared the cellular immune response (assessed in terms of IFN-γ production) to tetanus toxoid and to cytomegalovirus in a series of 13 ...


    pub_type: 杂志文章


    authors: Alsina L,Noguera-Julian A,Fortuny C

    更新日期:2013-05-07 00:00:00

  • Probiotics and colostrum/milk differentially affect neonatal humoral immune responses to oral rotavirus vaccine.

    abstract::Breast milk (colostrum [col]/milk) components and gut commensals play important roles in neonatal immune maturation, establishment of gut homeostasis and immune responses to enteric pathogens and oral vaccines. We investigated the impact of colonization by probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacteri...


    pub_type: 杂志文章


    authors: Chattha KS,Vlasova AN,Kandasamy S,Esseili MA,Siegismund C,Rajashekara G,Saif LJ

    更新日期:2013-04-08 00:00:00

  • Polio Eradication Initiative: Contribution to improved communicable diseases surveillance in WHO African region.

    abstract:INTRODUCTION:Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, there has been a tremendous progress in the reduction of cases of poliomyelitis. The world is on the verge of achieving global polio eradication and in May 2013, the 66th World Health Assembly endorsed the Polio Eradication and End...


    pub_type: 杂志文章


    authors: Mwengee W,Okeibunor J,Poy A,Shaba K,Mbulu Kinuani L,Minkoulou E,Yahaya A,Gaturuku P,Landoh DE,Nsubuga P,Salla M,Mihigo R,Mkanda P

    更新日期:2016-10-10 00:00:00

  • Cytokine production patterns and antibody response to measles vaccine.

    abstract::Cytokines play an important role in the immune response to live measles virus immunization. To gain further insight into the cytokine production profile in response to measles vaccination, we studied interferon-gamma (IFN-gamma), tumor necrosis factor (TNF-alpha), soluble IL-2 receptor (sIL-2R), interleukin-2 (IL-2), ...


    pub_type: 临床试验,杂志文章


    authors: Ovsyannikova IG,Reid KC,Jacobson RM,Oberg AL,Klee GG,Poland GA

    更新日期:2003-09-08 00:00:00

  • Expression of enterotoxigenic Escherichia coli colonization factors in Vibrio cholerae.

    abstract::As a first step towards a vaccine against diarrhoeal disease caused by enterotoxigenic Escherichia coli (ETEC), we have studied the expression of several ETEC antigens in the live attenuated Vibrio cholerae vaccine strain CVD 103-HgR. Colonization factors (CF) CFA/I, CS3, and CS6 were expressed at the surface of V. ch...


    pub_type: 杂志文章


    authors: Favre D,Lüdi S,Stoffel M,Frey J,Horn MP,Dietrich G,Spreng S,Viret JF

    更新日期:2006-05-15 00:00:00

  • Induction of sustained and elevated immune responses to weakly immunogenic synthetic malarial peptides by encapsulation in biodegradable polymer microspheres.

    abstract::Biodegradable microspheres (MS) based on poly(D,L-lactide) and poly(D,L-lactide-coglycolide) have the capacity to release encapsulated antigens over defined lengths of time depending on their composition and to elicit and sustain strong and long-lasting immune responses to protein antigens. In the present study, two s...


    pub_type: 杂志文章


    authors: Men Y,Gander B,Merkle HP,Corradin G

    更新日期:1996-10-01 00:00:00

  • Response to hepatitis-B vaccination in healthy homosexual individuals: retrospective case control study.

    abstract::The aim of the study was to compare the responses of homosexual men (HM) receiving a standard course of recombinant hepatitis B vaccine with those of healthcare workers vaccinated in the same hospital over the same period. Boosters for inadequate responders and repeat courses for non-responders were given. Forty of 61...


    pub_type: 杂志文章


    authors: Das S,Brassington M,Drake SM,Boxall E

    更新日期:2003-09-08 00:00:00

  • Assessment of neutralization of Micrurus venoms with a blend of anti-Micrurus tener and anti-ScNtx antibodies.

    abstract:BACKGROUND:Micrurus venoms contain two main groups of toxic protein components: short-chain α-neurotoxins (SNtx) and phospholipases type A2 (PLA2). In North America, generally, the Micrurus venoms have low abundance of SNtx compared to that of PLA2s; however, both are highly toxic to mammals, and consequently both can ...


    pub_type: 杂志文章


    authors: Archundia IG,de la Rosa G,Olvera F,Calderón A,Benard-Valle M,Alagón A,Corzo G

    更新日期:2021-02-05 00:00:00

  • Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV.

    abstract::Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae. Here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (CAV-2) expressing the VP2 protein of FPV (CAV-2-VP2) by transfection of MDCK cells with recombinant CAV-2 genome car...


    pub_type: 杂志文章


    authors: Yang S,Xia X,Qiao J,Liu Q,Chang S,Xie Z,Ju H,Zou X,Gao Y

    更新日期:2008-03-10 00:00:00

  • Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies.

    abstract::Mutations arising in neutralizing epitopes of hepatitis C virus may play a role in the ability of the virus to escape control by neutralizing antibodies and in the establishment of chronic infections. An amino-acid substitution, Q412H, within a major conserved neutralization epitope EP I (aa 412-426) in the E2 glycopr...


    pub_type: 杂志文章


    authors: Duan H,Struble E,Zhong L,Mihalik K,Major M,Zhang P,Feinstone S,Feigelstock D

    更新日期:2010-06-07 00:00:00

  • Development of a vaccine-challenge model for avian metapneumovirus subtype C in turkeys.

    abstract::The objective of this study was to evaluate different preparations of avian metapneumovirus (aMPV) subtype C as vaccine challenge in turkeys. Two aMPV isolates and their respective nasal turbinate homogenates after propagation in turkeys were used in the study. Significantly higher clinical sign scores were recorded i...


    pub_type: 杂志文章


    authors: Velayudhan BT,Noll SL,Thachil AJ,Shaw DP,Goyal SM,Halvorson DA,Nagaraja KV

    更新日期:2007-02-26 00:00:00

  • National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: emergence of serotype 19A with high invasive potential.

    abstract::We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged


    pub_type: 杂志文章,多中心研究


    authors: Hsieh YC,Lin PY,Chiu CH,Huang YC,Chang KY,Liao CH,Chiu NC,Chuang YC,Chen PY,Chang SC,Liu JW,Yen MY,Wang JH,Liu CY,Lin TY

    更新日期:2009-09-04 00:00:00

  • Good immunogenicity of GBM strain inactivated hepatitis A vaccine in healthy male adults.

    abstract::A formalin-inactivated aluminium hydroxide adsorbed hepatitis A vaccine was evaluated in a dose-response study on 195 healthy male adults (age range: 18-31 years) in two French hospitals (Lyon, Rouen). Four doses (20, 40, 80, 160 RIA antigen units) were administered intramuscularly (i.m.) in two injections over a 6-mo...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Garin D,Vidor E,Wallon M,Fanget B,Brasseur P,Delolme H,Caron F,Mojon M,Gravey A,Humbert G

    更新日期:1995-02-01 00:00:00

  • DNA vaccination with plasmids containing various fragments of large segment genome of infectious bursal disease virus.

    abstract::The present study was undertaken to determine the effectiveness in including VP2 gene of the large segment genome of infectious bursal disease virus (IBDV) in the DNA vaccine for protection of chickens against infectious bursal disease (IBD). Different fragments of the large segment gene of IBDV standard challenge (ST...


    pub_type: 杂志文章


    authors: Chang HC,Lin TL,Wu CC

    更新日期:2003-01-17 00:00:00

  • Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine.

    abstract::TA-CIN is a vaccine that comprises the human papillomavirus (HPV) type 16 L2, E6 and E7 as a single fusion protein. In a mouse model, TA-CIN effectively prevented outgrowth of HPV16-positive tumour cells. To assess the safety and immunogenicity of TA-CIN, a dose escalating (26, 128, 533 micro g), double blind and plac...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Jong A,O'Neill T,Khan AY,Kwappenberg KM,Chisholm SE,Whittle NR,Dobson JA,Jack LC,St Clair Roberts JA,Offringa R,van der Burg SH,Hickling JK

    更新日期:2002-10-04 00:00:00

  • Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE).

    abstract::Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligman, Gould, Lancet 2004;363:2073-5], it has little foundation [e.g., Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond J, Lang J, et al. Vaccine 2005;23:2956-8]. To invest...


    pub_type: 杂志文章


    authors: Pugachev KV,Schwaiger J,Brown N,Zhang ZX,Catalan J,Mitchell FS,Ocran SW,Rumyantsev AA,Khromykh AA,Monath TP,Guirakhoo F

    更新日期:2007-09-17 00:00:00

  • Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidate.

    abstract::A multi-component vaccine has been defined, which contains six different synthetic 24- to 32-amino acid lipopeptides derived from the sequence of HIV-1 proteins. The physicochemical properties of the lipopeptide components were compatible with multi-dimensional analysis, using RP-HPLC, Edman sequencing, electrospray m...


    pub_type: 杂志文章


    authors: Klinguer C,David D,Kouach M,Wieruszeski JM,Tartar A,Marzin D,Levy JP,Gras-Masse H

    更新日期:1999-09-01 00:00:00

  • Clinical experience with inactivated, virosomal influenza vaccine.

    abstract::Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Bruijn IA,Nauta J,Cramer WC,Gerez L,Palache AM

    更新日期:2005-07-08 00:00:00

  • Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant.

    abstract::Aluminium-containing adjuvants are often used to enhance the potency of vaccines. In the present work we studied whether adsorption of diphtheria toxoid to colloidal aluminium hydroxide induces conformational changes of the antigen. Diphtheria toxoid has a high affinity for the aluminium hydroxide particles based on a...


    pub_type: 杂志文章


    authors: Régnier M,Metz B,Tilstra W,Hendriksen C,Jiskoot W,Norde W,Kersten G

    更新日期:2012-11-06 00:00:00

  • The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs.

    abstract::The immunological enhancement characteristics of the immunopotentiator CVC1302 were evaluated for foot-and-mouth disease virus (FMDV) inactivated vaccine in pigs. Eight-week-old piglets were vaccinated with the foot-and-mouth disease (FMD) vaccine alone (FMD-vaccine group) or with the addition of CVC1302 (FMD-CVC1302 ...


    pub_type: 杂志文章


    authors: Chen J,Yu X,Zheng Q,Hou L,Du L,Zhang Y,Qiao X,Hou J,Huang K

    更新日期:2018-12-18 00:00:00

  • Successful DNA immunisation of rats against fasciolosis.

    abstract::The liver fluke Fasciola hepatica contributes to great economic and health losses in the cattle industry in many countries, including Poland. Unfortunately, no vaccine against fasciolosis is commercially available. We have designed a DNA vaccine and tested it in rats. Groups of male or female rats received one intramu...


    pub_type: 杂志文章


    authors: Kofta W,Mieszczanek J,Płucienniczak G,Wedrychowicz H

    更新日期:2000-07-01 00:00:00

  • Safety, tolerability and efficacy of intradermal rabies immunization with DebioJect™.

    abstract::In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also called Mantoux method, and intramuscular with classical needle (IM)...


    pub_type: 杂志文章


    authors: Vescovo P,Rettby N,Ramaniraka N,Liberman J,Hart K,Cachemaille A,Piveteau LD,Zanoni R,Bart PA,Pantaleo G

    更新日期:2017-03-27 00:00:00

  • Rectal immunization with antigen-containing microspheres induces stronger Th2 responses than oral immunization: a new method for vaccination.

    abstract::The rectum as an effective site for induction of systemic and local immunity has received little attention. Rectal immunization with microspheres-containing ovalbumin (MS-OVA) was tested for its ability to elicit systemic and mucosal immune responses. Rectal immunization with MS-OVA enhanced both Th2 dominant OVA-spec...


    pub_type: 杂志文章


    authors: Nakase H,Okazaki K,Tabata Y,Uchida K,Uose S,Ohana M,Nishi T,Watanabe T,Matsuura M,Hisatsune H,Matsumura K,Itoh T,Kawanami C,Chiba T

    更新日期:2001-11-12 00:00:00

  • Vaccination against the 2009 pandemic influenza A (H1N1) among healthcare workers in the major teaching hospital of Sicily (Italy).

    abstract::The aim of the study was to investigate factors involved in vaccination acceptance among healthcare workers (HCWs) and adverse reactions rates associated with pandemic influenza vaccination. The study was carried out in the major teaching hospital of Sicily from November 2009 to February 2010 on 2267 HCWs. A total of ...


    pub_type: 杂志文章


    authors: Amodio E,Anastasi G,Marsala MG,Torregrossa MV,Romano N,Firenze A

    更新日期:2011-02-04 00:00:00