Abstract：
:We have demonstrated that the fibrinogen-albumin-IgG receptor of group C streptococci (FAI) targets B-cells in vivo. We exploited the targeting properties of FAI to improve the immune responses stimulated by soluble antigens administered by the mucosal route. Enhanced systemic and mucosal immune responses were observed in mice after intranasal immunization when ovalbumin was fused to FAI or truncated derivatives. The FAI fragment encompassing the IgG- and fibrinogen-binding regions was the minimal domain exhibiting optimal carrier/adjuvant properties. The obtained results suggest that the FAI protein represents a useful tool to improve the immunogenicity of vaccine antigens.
journal_name
Vaccinejournal_title
Vaccineauthors
Schulze K,Goldmann O,Toppel A,Medina E,Guzmán CAdoi
10.1016/j.vaccine.2004.08.045subject
Has Abstractpub_date
2005-02-03 00:00:00pages
1408-13issue
11eissn
0264-410Xissn
1873-2518pii
S0264-410X(04)00682-6journal_volume
23pub_type
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