Stable expression and secretion of the B-cell epitope of rodent malaria from Mycobacterium bovis BCG and induction of long-lasting humoral response in mouse.

abstract：:Mumps virus is still circulating and annual mumps outbreaks occur with fluctuating magnitudes in Japan. Aseptic meningitis has been reported after vaccination and it would be of importance to determine whether this was related to the vaccination. The objective of this study was to develop a sensitive, specific and rap...

journal_title：Vaccine

authors： Yoshida N,Fujino M,Ota Y,Notomi T,Nakayama T

更新日期：2007-01-26 00:00:00

abstract：:The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the intro...

journal_title：Vaccine

authors： Ribeiro GS,Lima JB,Reis JN,Gouveia EL,Cordeiro SM,Lobo TS,Pinheiro RM,Ribeiro CT,Neves AB,Salgado K,Silva HR,Reis MG,Ko AI

更新日期：2007-05-30 00:00:00

abstract：:An economic evaluation of reducing the age threshold for routine influenza vaccination in Spain from 65 to 50 years was performed. A probabilistic model was used to compare a policy based on a recommendation to vaccinate all adults aged 50-64 with the existing vaccination policy for that age group, during interpandemi...

journal_title：Vaccine

authors： Aballéa S,De Juanes JR,Barbieri M,Martin M,Chancellor J,Oyagüez I,Verwee B,Largeron N

更新日期：2007-09-28 00:00:00

abstract：:The recovery of wild type and attenuated human parainfluenza type 3 (PIV3) recombinant viruses has made possible a new strategy to rapidly generate a live-attenuated vaccine virus fof PIV1. We previously replaced the coding sequences for the hemagglutinin-neuraminidase (HN) and fusion (F) proteins of PIV3 with those o...

journal_title：Vaccine

authors： Tao T,Skiadopoulos MH,Durbin AP,Davoodi F,Collins PL,Murphy BR

更新日期：1999-03-05 00:00:00

abstract：:An effective vaccination strategy against human immunodeficiency virus type 1 (HIV-1) should include the induction of potent cellular immune responses against conserved HIV-1 antigens. We have generated five replication competent recombinant influenza viruses (rFlu/SIV Gag nos. 1-5) expressing different portions of Ga...

journal_title：Vaccine

authors： Nakaya Y,Zheng H,García-Sastre A

更新日期：2003-05-16 00:00:00

abstract：:CD1d-binding glycolipids exert potent adjuvant effects on T-dependent Ab responses. The mechanisms include cognate interaction between CD1d-expressing B cells and TCR-expressing Type I CD1d-restricted natural killer T cells (NKTs). However, the critical NKT-derived factors that stimulate B cells are poorly understood....

journal_title：Vaccine

authors： Shah HB,Joshi SK,Lang ML

更新日期：2011-11-15 00:00:00

abstract：:Measles, mumps and rubella (MMR) vaccination coverage in Italy has been decreasing starting from 2012 and, at the present, none of the Italian regions has achieved the goal of 95% coverage target. A decision of the Court of Justice of Rimini in March 2012 that awarded vaccine-injury compensation for a case of autism h...

journal_title：Vaccine

authors： Aquino F,Donzelli G,De Franco E,Privitera G,Lopalco PL,Carducci A

更新日期：2017-08-16 00:00:00

abstract：:A bovine herpesvirus 4 was isolated from the milk cell fraction of a healthy cow and his full genome cloned as a bacterial artificial chromosome. So cloned viral genome was used as a vector platform to deliver in vitro and in vivo an optimized secreted chimeric peptide obtained by the fusion of the bovine viral diarrh...

journal_title：Vaccine

authors： Donofrio G,Sartori C,Franceschi V,Capocefalo A,Cavirani S,Taddei S,Flammini CF

更新日期：2008-11-11 00:00:00

abstract：:Dengue is a significant threat to public health worldwide. Currently, there are no licensed vaccines available for dengue. Takeda Vaccines Inc. is developing a live, attenuated tetravalent dengue vaccine candidate (TDV) that consists of an attenuated DENV-2 strain (TDV-2) and three chimeric viruses containing the prM ...

journal_title：Vaccine

authors： Osorio JE,Partidos CD,Wallace D,Stinchcomb DT

更新日期：2015-12-10 00:00:00

abstract：:The World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Bill & Melinda Gates Foundation convened the first Global Vaccine and Immunization Research Forum (GVIRF) in March 2014. This first GVIRF aimed to track recent progress of the Gl...

journal_title：Vaccine

authors： Ford AQ,Touchette N,Hall BF,Hwang A,Hombach J

更新日期：2016-03-18 00:00:00

abstract：:The safety and immunogenicity of two PorA-based meningococcal outer membrane vesicle (OMV) vaccines against the P1.4 serosubtype adsorbed with AlPO(4) or Al(OH)(3) were studied in 134 toddlers. Vaccinations were given three times with an interval of 3-6 weeks or twice with an interval of 6-10 weeks. A vaccination was ...

journal_title：Vaccine

authors： de Kleijn ED,de Groot R,Lafeber AB,Labadie J,van Limpt KC,Visser J,Berbers GA,van Alphen L,Rümke HC

更新日期：2000-12-08 00:00:00

abstract：:The effects on the immunity in cattle of dosage and storage of oil-based inactivated vaccine incorporating the Gladysdale strain were examined. Storage at 4 degrees C for 12 or 24 months was found not to have any marked effect on the immunity conferred in the vaccinated cattle. A dosage of 0.5 ml was found to be as ef...

journal_title：Vaccine

authors： Garba SA,Terry RJ

更新日期：1986-12-01 00:00:00

abstract：:The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has residual toxicity that can be detected in cell-based assays and in-viv...

journal_title：Vaccine

authors： Wang B,Wang S,Rustandi RR,Wang F,Mensch CD,Hong L,Kristopeit A,Secore S,Dornadula G,Kanavage A,Heinrichs JH,Mach H,Blue JT,Thiriot DS

更新日期：2015-01-01 00:00:00

abstract：:Attenuated strains of Salmonella have been used as vaccines to deliver heterologous antigens mainly to generate a humoral immune response. However, little is known about their ability to induce a cell-mediated immune response to the T-cell epitopes of another infectious agent or how optimally to deliver these epitopes...

journal_title：Vaccine

authors： Verma NK,Ziegler HK,Stocker BA,Schoolnik GK

更新日期：1995-02-01 00:00:00

abstract：:The use of vaccinia virus in recombinant systems may result in the occurrence of complications observed following smallpox vaccination. The results are presented of a large survey carried out in the USSR between 1968 and 1979. High complication rates are reported, particularly in older primary vaccinees; for example, ...

journal_title：Vaccine

authors： Gurvich EB

更新日期：1992-01-01 00:00:00

abstract：:The 9th African rotavirus symposium was held in Maputo, Mozambique from the 8th to 10th of December 2015, including a total of 101 delegates from 17 countries, 15 of which were African countries. This forum brought together participants with various expertise including scientists, clinicians, immunization program mana...

journal_title：Vaccine

authors： Mandomando I,Weldegebriel G,de Deus N,Mwenda JM

更新日期：2017-03-23 00:00:00

abstract：:The aims of this study were to estimate influenza vaccination coverage for children during the 2006-2007 influenza season in Ontario, Canada, where universal vaccination is available, and to compare the rate among children aged 6-23 months with corresponding rates from other Canadian provinces that specifically target...

journal_title：Vaccine

authors： Moran K,Maaten S,Guttmann A,Northrup D,Kwong JC

更新日期：2009-04-14 00:00:00

abstract：:The outer capsid protein VP4 is an important target for the development of a recombinant rotavirus vaccine because it mediates the attachment and penetration of rotavirus. Due to the poor solubility of full-length VP4, VP8 was explored as candidate rotavirus vaccines in the past years. In previous studies, it has been...

journal_title：Vaccine

authors： Li Y,Xue M,Yu L,Luo G,Yang H,Jia L,Zeng Y,Li T,Ge S,Xia N

更新日期：2018-04-12 00:00:00

abstract：:The physico-chemical characterization of NadADelta(351-405), a recombinant protein discovered by reverse vaccinology, component of a candidate vaccine against Neisseria meningitidis serotype B is presented. Analytical methods like mass spectrometry, electrophoresis, optical spectroscopy and SEC-MALLS have been applied...

journal_title：Vaccine

authors： Magagnoli C,Bardotti A,De Conciliis G,Galasso R,Tomei M,Campa C,Pennatini C,Cerchioni M,Fabbri B,Giannini S,Mattioli GL,Biolchi A,D'Ascenzi S,Helling F

更新日期：2009-03-26 00:00:00

abstract：:Carcinoembryonic antigen (CEA), which is expressed in several cancer types, is a potential target for specific immunotherapy. In this study, the feasibility of using dendrite cells (DCs) for tumor immunotherapy after transduction with a recombinant adenovirus containing CEA gene (AdVCEA) was investigated. The recombin...

journal_title：Vaccine

authors： Cho HI,Kim HJ,Oh ST,Kim TG

更新日期：2003-12-12 00:00:00

abstract：:Immunological memory induced by nasal immunization with adjuvant-combined influenza vaccine was analyzed in different ages and strains of mice. The memory activities were assessed by secondary nasal-wash IgA and serum IgG antibody (Ab) responses and protection against challenge infection with a lethal dose of influenz...

journal_title：Vaccine

authors： Asanuma H,Fujihashi K,Miyakoshi T,Yoshikawa T,Fujita-Yamaguchi Y,Kojima N,Nakata M,Suzuki Y,Tamura S,Kurata T,Sata T

更新日期：2007-09-28 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In t...

journal_title：Vaccine

authors： Goetsch L,Plotnicky-Gilquin H,Aubry JP,De-Lys P,Haeuw JF,Bonnefoy JY,Nguyen NT,Corvaïa N,Velin D

更新日期：2001-07-16 00:00:00

abstract：:Fusions of dendritic cells (DCs) and tumour cells have been shown to induce protective immunity to tumour challenge in animal models, and to represent a promising approach to cancer immunotherapy. The broader clinical application of this approach, however, is potentially constrained by the lack of replicative capacity...

journal_title：Vaccine

authors： Mohamed YS,Dunnion D,Teobald I,Walewska R,Browning MJ

更新日期：2012-10-12 00:00:00

abstract：BACKGROUND:Rotavirus is a leading cause of childhood morbidity and mortality worldwide. Clinical trials for two rotavirus vaccines recommended by the WHO for global use since 2009 have successfully demonstrated the safety and efficacy of these vaccines in a wide range of countries. To control the burden of severe and f...

journal_title：Vaccine

authors： Benhafid M,Rguig A,Trivedi T,Elqazoui M,Teleb N,Mouane N,Maltouf AF,Parashar U,Patel M,Aouad RE

更新日期：2012-10-12 00:00:00

abstract：:We report the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed Lactococcus lactis-derived delivery system, called Gram-positive Enhancer Matrix (GEM). The GEM particles induced the produc...

journal_title：Vaccine

authors： Audouy SA,van Selm S,van Roosmalen ML,Post E,Kanninga R,Neef J,Estevão S,Nieuwenhuis EE,Adrian PV,Leenhouts K,Hermans PW

更新日期：2007-03-22 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in young children. We have engineered a recombinant candidate vaccine G1F/M2, consisting of a cytotoxic T lymphocyte (CTL) epitope of RSV-M2 protein and a domain of RSV-G protein. In this study, the long-term immunogenici...

journal_title：Vaccine

authors： Zeng R,Qi X,Gong W,Mei X,Wei L,Ma C,Yin X

更新日期：2007-10-16 00:00:00

abstract：:A large, randomized, placebo-controlled clinical trial in Italy on two three-component pertussis vaccines, given as DTaP in infancy, one manufactured by SmithKline and Beecham (SB) and one by Chiron Biocine (CB), found each vaccine to be 84% efficacious through the average age of 24 months. The cohort of children enro...

journal_title：Vaccine

authors： Salmaso S,Mastrantonio P,Wassilak SG,Giuliano M,Anemona A,Giammanco A,Tozzi AE,Ciofi degli Atti ML,Greco D

更新日期：1998-08-01 00:00:00

abstract：:We report on 30 in-depth mental models interviews with parents discussing vaccination for their children, both in general terms and in response to communications drawn from sources supporting and opposing vaccines. We found that even parents favourable to vaccination can be confused by the ongoing debate, leading them...

journal_title：Vaccine

authors： Downs JS,de Bruin WB,Fischhoff B

更新日期：2008-03-17 00:00:00

abstract：OBJECTIVE:This case-control study investigated the relationship between the risk of Autism Spectrum Disorder (ASD) onset, and early exposure to the combined Measles-Mumps-Rubella (MMR) vaccine and thimerosal consumption measured from vaccinations in the highly genetically homogenous Japanese population. METHODS:Vaccin...

journal_title：Vaccine

authors： Uno Y,Uchiyama T,Kurosawa M,Aleksic B,Ozaki N

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Ebola viral disease (EVD) epidemic need to be contained through means which include vaccination of susceptible population. Vaccination has eradicated major killer diseases. OBJECTIVE:The study determined the health workers willingness to participate in EVD vaccine clinical trials and receive EVD vaccine. M...

journal_title：Vaccine

authors： Olowookere SA,Abioye-Kuteyi EA,Adekanle O

更新日期：2016-11-11 00:00:00